Dichloroacetate

Dichloroacetate Uses, Dosage, Side Effects, Food Interaction and all others data.

Dichloroacetate, often abbreviated DCA, is an acid analogue of acetic acid in which two of the three hydrogen atoms of the methyl group have been replaced by chlorine atoms. Salts of DCA are used as drugs since they inhibit the enzyme pyruvate dehydrogenase kinase. Early reports of its activity against brain cancer cells led patients to treat themselves with DCA, which is commercially available in non-pharmaceutical grade. A phase 1 study in 5 patients concluded that DCA was safe, but wasn't designed to establish effectiveness.

DCA was approved for use in Canada in 1989 (as a topical formulation for treatment of warts and for cauterization and removal of a wide variety of skin and tissue lesions), but was cancelled post market.

Trade Name Dichloroacetate
Generic Dichloroacetic acid
Dichloroacetic acid Other Names Dichloracetic acid, Dichloroacetate
Type
Formula C2H2Cl2O2
Weight Average: 128.942
Monoisotopic: 127.943184722
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Dichloroacetate
Dichloroacetate

Toxicity

ORAL (LD50): Acute: 2820 mg/kg [Rat]; DERMAL (LD50): Acute: 510 mg/kg Rabbit

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