Difenoxilato

Difenoxilato Uses, Dosage, Side Effects, Food Interaction and all others data.

A meperidine congener used as an antidiarrheal, usually in combination with atropine. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity. This medication is classified as a Schedule V under the Controlled Substances Act by the Food and Drug Administration (FDA) and the DEA in the United States when used in preparations. When diphenoxylate is used alone, it is classified as a Schedule II.

Difenoxilato, an antidiarrheal, is effective as adjunctive therapy in the management of diarrhea. Difenoxilato is rapidly and extensively metabolized in man by ester hydrolysis to diphenoxylic acid (difenoxine), which is biologically active and the major metabolite in the blood.

Difenoxilato
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Difenoxilato
Generic	Diphenoxylate
Diphenoxylate Other Names	Difenossilato, Difenoxilato, Diphenoxylate, Diphenoxylatum
Type
Formula	C₃₀H₃₂N₂O₂
Weight	Average: 452.5873 Monoisotopic: 452.246378278
Protein binding	74-95%
Groups	Approved, Illicit
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Difenoxilato is an antidiarrheal medication used with atropine to manage diarrhea.

For as adjunctive therapy in the management of diarrhea

Difenoxilato is also used to associated treatment for these conditions: Diarrhoea

How Difenoxilato works

Difenoxilato is an opiate receptor agonists that stimulate mu receptors in GI to decrease the peristalsis and constrict the sphincters. Difenoxilato has a direct effect on circular smooth muscle of the bowel, that conceivably results in segmentation and prolongation of gastrointestinal transit time. The clinical antidiarrheal action of diphenoxylate may thus be a consequence of enhanced segmentation that allows increased contact of the intraluminal contents with the intestinal mucosa.

Toxicity

Coma, dry skin and mucous membranes, enlarged pupils of the eyes, extremely high body temperature, flushing, involuntary eyeball movement, lower than normal muscle tone, pinpoint pupils, rapid heartbeat, restlessness, sluggishness, suppressed breathing