Diflorasona

Diflorasona Uses, Dosage, Side Effects, Food Interaction and all others data.

Like other topical corticosteroids, Diflorasona Diacetate has anti-inflammatory, anti-pruritic and vasoconstrictive actions. The mechanism of the anti-inflammatory activity of the topical corticosteroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.

Like other topical corticosteroids, diflorasone has anti-inflammatory, antipruritic, and vasoconstrictive properties. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Diflorasona is a potent topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved.

Diflorasona
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Diflorasona
Availability	Prescription only
Generic	Diflorasone
Diflorasone Other Names	Diflorasona, Diflorasone, Diflorasonum
Related Drugs	Humira, Cosentyx, Dupixent, prednisone, cetirizine, loratadine, methotrexate, promethazine, diphenhydramine, Zyrtec
Type
Formula	C₂₂H₂₈F₂O₅
Weight	Average: 410.4515 Monoisotopic: 410.190480416
Protein binding	Bound to plasma proteins in varying degrees.
Groups	Approved
Therapeutic Class	Other Topical corticosteroids
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Diflorasona Diacetate cream & ointment are used for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Diflorasona is also used to associated treatment for these conditions: Dermatosis

How Diflorasona works

The precise mechanism of the antiinflammatory activity of topical steroids in the treatment of steroid-responsive dermatoses, in general, is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A₂ inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A₂.

Dosage

Diflorasona dosage

Apply to the affected areas as a thin film from one to four times daily depending on the severity of the condition. Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions. If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy should be instituted.

Side Effects

The following adverse effects have been reported infrequently with topical corticosteroids. These reactions include burning, itching, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infections, skin atrophy, striae and miliaria.

Toxicity

Topically applied diflorasone can be absorbed in sufficient amounts to produce systemic effects. Symptoms of overdose include thinning of skin and suppression of adrenal cortex (decreased ability to respond to stress).

Food Interaction

No interactions found.

Diflorasona Disease Interaction

Moderate: diabetes, diaper rash, hyperadrenocorticism, infections, ocular toxicities

Elimination Route

Topical corticosteroids can be absorbed from intact healthy skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors, including the vehicle and the integrity of the epidermal barrier. Occlusion, inflammation and/or other disease processes in the skin may also increase percutaneous absorption.

Pregnancy & Breastfeeding use

Topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. Therefore caution should be exercised when topical corticosteroids are administered to a nursing woman.

Contraindication

Diflorasona Diacetate is contraindicated in those patients with a history of hypersensitivity to the preparation. Systemic absorption of topical corticosteroids may cause reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of cushing's syndrome, hyperglycemia, and glucosuria. Patients receiving large dose of a potent topical steroid applied to a large surface area or under an occlusive dressing should be evaluated periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests. If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent steroid. Safety and effectiveness of Diflorasona Diacetate cream & ointment in paediatric patients have not been established. Paediatric patients are at greater risk than adults of HPA axis suppression when they are treated with topical corticosteroids.