Dihomo-gamma-linolenic acid
Dihomo-gamma-linolenic acid Uses, Dosage, Side Effects, Food Interaction and all others data.
A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5.
Dihomo gamma-linolenic acid or DHLA is an n-6 (omega-6) polyunsaturated fatty acid. It is comprised of 20 carbon atoms and three double bonds. DHLA is a byproduct of the 18 carbon gamma-linolenic acid (GLA). DHLA is then converted into prostaglandin E1 (PGE1). PGE1 inhibits platelet aggregation and also exerts a vasodilatory effect.
| Trade Name | Dihomo-gamma-linolenic acid |
| Generic | Dihomo-gamma-linolenic acid |
| Dihomo-gamma-linolenic acid Other Names | 8c,11c,14c-Eicosatriensäure, all-cis-Eicosa-8,11,14-triensäure, DGLA, gamma-Homolinolenic acid, Homo-gamma-linolenic acid, Homo-gamma-linolensäure, Homo-γ-linolensäure |
| Type | |
| Formula | C20H34O2 |
| Weight | Average: 306.4828 Monoisotopic: 306.255880332 |
| Groups | Investigational, Nutraceutical |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For nutritional supplementation, also for treating dietary shortage or imbalance
How Dihomo-gamma-linolenic acid works
DHLA (or DGLA) is a precursor in the synthesis of prostaglandin E1 (PGE1) as well as the series-3 prostaglandins. It also serves as a precursor in the synthesis of eicosapentaenoic acid (EPA). EPA is a precursor of the series-3 prostaglandins, the series-5 leukotrienes and the series-3 thromboxanes. These eicosanoids have anti-thrombogenic, anti-inflammatory and anti-atherogenic properties. PGE1 inhibits platelet aggregation and has a vasodilation action. DHLA has also been shown to reduce the production/activity of tumor necrosis factor alpha.
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