Diisopropoxyphosphoryl Fluoride
Diisopropoxyphosphoryl Fluoride Uses, Dosage, Side Effects, Food Interaction and all others data.
An irreversible cholinesterase inhibitor with actions similar to those of echothiophate. It is a powerful miotic used mainly in the treatment of glaucoma. Its vapor is highly toxic and it is recommended that only solutions in arachis oil be used therapeutically. (From Martindale, The Extra Pharmacopoeia, 29th ed, p1330)
Diisopropoxyphosphoryl Fluoride is used as ocular drops in the treatment of chronic glaucoma. Diisopropoxyphosphoryl Fluoride is an organophosphorus compound that acts as an irreversible cholinesterase inhibitor. As such, it displays parasympathomimetic effects. Diisopropoxyphosphoryl Fluoride is used in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia. They may also be used in the diagnosis of certain eye conditions, such as accommodative esotropia. Diisopropoxyphosphoryl Fluoride damages the acetylcholinesterase enzyme and is therefore irreversible, however, pralidoxime can displace organophosphates such as isoflurophate from acetylcholinesterase, but only if administered before isoflurophate damages (alkylates) the enzyme.
| Trade Name | Diisopropoxyphosphoryl Fluoride |
| Generic | Isoflurophate |
| Isoflurophate Other Names | Diisopropoxyphosphoryl fluoride, Diisopropyl fluorophosphate, Diisopropyl fluorophosphonate, Diisopropyl phosphofluoridate, Diisopropyl phosphorofluoridate, Diisopropylfluorophosphate, Diisopropylfluorophosphoric acid ester, Diisopropylphosphofluoridate, Diisopropylphosphorofluoridate, Fluorodiisopropyl phosphate, Fluorostigmine, Isofluorphate, Isoflurophate, Isoflurophosphate, Isopropyl fluophosphate, Isopropyl phosphorofluoridate |
| Type | |
| Formula | C6H14FO3P |
| Weight | Average: 184.1457 Monoisotopic: 184.066459031 |
| Groups | Approved, Investigational, Withdrawn |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia.
How Diisopropoxyphosphoryl Fluoride works
The mechanism of isoflurophate's action involves the irreversible inhibition of cholinesterase.
Toxicity
Signs of overdose include increased sweating, loss of bladder control, muscle weakness, nausea, vomiting, diarrhea, or stomach cramps or pain, shortness of breath, tightness in chest, or wheezing, slow or irregular heartbeat, unusual tiredness or weakness, watering of mouth.
Innovators Monograph
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