Dilamide Tablet 500 mg
Dilamide Tablet 500 mg Uses, Dosage, Side Effects, Food Interaction and all others data.
Diloxanide is a luminal amoebicide which is hydrolysed in the gut, thus releasing the free diloxanide which acts as an amoebicide. It is given alone in asymptomatic cyst passers. For patients with active amoebic infections, it can be administered with a 5-nitroimidazole e.g. metronidazole or tinidazole.
Diloxanide is a luminal amebicide, however the mechanism of action of diloxanide is unknown. Diloxanide destroys the trophozoites of E. histolytica that eventually form into cysts. The cysts are then excreted by persons infected with asymptomatic amebiasis. Diloxanide furoate is a prodrug, and is hydrolyzed in the gastrointestinal tract to produce diloxanide, the active ingredient.
| Trade Name | Dilamide Tablet 500 mg |
| Generic | Diloxanide Furoate |
| Diloxanide Furoate Other Names | Dichlofurazol, Diloxanide furoate, Diloxanidi furoas |
| Weight | 500 mg |
| Type | Tablet |
| Formula | C14H11Cl2NO4 |
| Weight | Average: 328.147 Monoisotopic: 327.006513259 |
| Groups | Approved |
| Therapeutic Class | Amoebicides |
| Manufacturer | Pharmadesh Laboratories Ltd. |
| Available Country | Bangladesh |
| Last Updated: | October 19, 2023 at 6:27 am |
Uses
Diloxanide is used for intestinal amoebiasis
How Dilamide Tablet 500 mg works
Unknown. Diloxanide may inhibit protein synthesis.
Dosage
Dilamide Tablet 500 mg dosage
Adult: The recommended dose is 500 mg 3 times/day for 10 days. May repeat course if needed.
Child: >25 kg: 20 mg/kg daily in 3 divided doses for 10 days, repeated if necessary.
Side Effects
The frequency of these side-effects is unknown flatulence, itching, urticaria, vomiting
Precaution
Caution should be exercised in pregnant and breastfeeding women. Avoid excess dosage.
Interaction
There are no known drug interactions and none well documented.
Elimination Route
Bioavailability is 90% (in diloxanide parental form), however diloxanide furoate is slowly absorbed from the gastrointestinal tract.
Half Life
3 hours
Elimination Route
Renal (90%, rapidly excreted as glucuronide metabolite). 10% is excreted in the feces as diloxanide.
Pregnancy & Breastfeeding use
Pregnancy Category- Not Classified. FDA has not yet classified the drug into a specified pregnancy category.
Contraindication
Hypersensitivity.
Innovators Monograph
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