Dio PP

Dio PP Uses, Dosage, Side Effects, Food Interaction and all others data.

Chronic venous insufficiency is a common condition the western population. Compression and pharmacotherapy are frequently used to manage chronic venous insufficiency, improving circulation and symptoms of venous disease.

Dio PP is a bioflavonoid isolated from various plants or synthesized from hesperidin. It is used for the improvement of capillary fragility or venous insufficiency, including chronic venous insufficiency (CVI) and hemorrhoids. Dio PP is widely available over-the-counter and demonstrates a favourable a favorable safety profile.

Dio PP is a venoactive drug supporting circulatory health through various actions on blood vessels; it supports lymphatic drainage and improves microcirculation while increasing venous tone and elasticity. For these reasons, diosmin is frequently taken by individuals with chronic venous disease to support vascular health and has been demonstrated to improve quality of life. In addition to the above effects, diosmin exerts antioxidant activity and scavenges oxygen free radicals, reducing levels of oxidative stress normally detected through biomarkers such as prostaglandins isoprostane precursors.

Dio PP
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Dio PP
Generic	Diosmin
Diosmin Other Names	Diosmin, Diosmina, Diosmine, Diosminum
Type
Formula	C₂₈H₃₂O₁₅
Weight	Average: 608.5447 Monoisotopic: 608.174120354
Protein binding	Diosmin binds to serum albumin.
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	Hungary
Last Updated:	September 19, 2023 at 7:00 am

Uses

Dio PP is a citrus flavonoid medication used to support vascular health.

Dio PP is used over-the-counter alone or with ingredients such as hesperidin and diosmetin to support vein and capillary function.

Dio PP is also used to associated treatment for these conditions: Capillary fragility, Circulatory Function, Hemorrhoids, Venous Insufficiency, Healthy capillaries, Healthy veins

How Dio PP works

Dio PP helps to maintain circulatory system structure and function, particularly vein strength and competence. The molecular mechanism of action of diosmin has not been established. Several resources indicate that diosmin binds to the aryl hydrocarbon receptor, however clinical relevance to vascular function is unknown. One study demonstrates that oral diosmin exerts effects on the in vitro metabolism of noradrenaline by varicose veins, potentially benefitting vascular health.

Toxicity

The LD50 of diosmin is >3g/kg in animal studies, with an LD50 of great than 3000 mg/kg in rats. No cases of overdose have been reported, however, an overdose is likely to result in gastrointestinal effects such as nausea, dyspepsia, vomiting, and diarrhea.

Food Interaction

Take with or without food.

Volume of Distribution

A pharmacokinetic study of 5 adults revealed a volume of distribution of 62.1±7.9 L.

Elimination Route

Dio PP is rapidly absorbed in the gastrointestinal tract. After a 900 mg single oral dose in a study using liquid chromatography with tandem mass spectrometry (LC-MS/MS) method, Cmax was 4.2±3.8 ^{ng·mL-1 Another pharmacokinetic study of 5 adults revealed a Cmax of 417±94.1 ng/dL.}

Half Life

Dio PP half-life ranges from 26 to 43 hours. One study using a liquid chromatography with tandem mass spectrometry (LC-MS/MS) method after a single 900 mg dose of diosmin demonstrated a half-life of 60.2±85.7 hours in healthy volunteers.

Elimination Route

Pharmacokinetic data show absence of urinary elimination for diosmin and its aglycone diosmetin. Minor metabolites are found to be eliminated in the urine as glucuronic acid conjugates.