Diovol

Uses

Aluminium Hydroxide is used for Duodenal ulcer, Dyspepsia, Flatulence, Gastric Hyperacidity, Gastric ulcer, Gastritis, Gastroesophageal reflux disease (GERD), Gastrointestinal hyperacidity, Heartburn, Heartburn & gastritis, Hyperacidity, Indigestion, Oesophagitis, Peptic ulcer disease, Stomach distension, Upper Gl bloating.

Magnesium carbonate is an antacid used for symptomatic relief of heartburn, indigestion, and upset stomach.

Used as an over the counter antacid .

Diovol is also used to associated treatment for these conditions: Acid indigestion, Bladder calculus, Heartburn, Kidney Stones, Upset stomach, Catheter irrigation

How Diovol works

Magnesium carbonate reacts with hydrochloric acid in the stomach to form carbon dioxide and magnesium chloride thus neutralizing excess acid in the stomach .

Dosage

Diovol dosage

Usual Adult Dose: Up to 1 g daily.

Dyspepsia: 500 to 600 mg orally 4 to 6 times a day as needed, between meals and at bedtime.

Duodenal Ulcer: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime.

Erosive Esophagitis: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime.

Gastric Ulcer: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime.

Gastroesophageal Reflux Disease: 500 to 1500 mg orally 4 to 6 times a day as needed, between meals and at bedtime.

Zollinger-Ellison Syndrome: 500 to 3600 mg orally 4 to 6 times a day as needed, between meals and at bedtime.

Hyperphosphatemia: 500 to 1000 mg orally 4 times a day, with meals and at bedtime. The dosage should be titrated to the serum phosphate level. Max Dosage: 10 g daily in divided doses may be taken with or without food.

Side Effects

Constipation; intestinal obstruction (with large doses); phosphate depletion may occur with prolonged admin or large doses.

Toxicity

During overdose, magnesium impairs neuromuscular transmission resulting in weakness and hypoflexia .

Precaution

Chronic renal impairment; CHF; oedema; cirrhosis and low Na diets; patients with recent Gl haemorrhage. Administer 2-3 hrs before/after another medication to minimise drug interactions. Pregnancy and lactation

Interaction

Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.

Volume of Distribution

Vd for magnesium is 0.2-0.4L/kg . About 50% distributes to bone.

Elimination Route

About 40-60% of magnesium is absorbed following oral administration . Percent absorption decreases as dose increases.

Half Life

Half life of 27.7 hours reported with overdose of 400mEq of magnesium in an adult .

Clearance

Maximum magnesium clearance is directly proportional to creatinine clearance .

Elimination Route

Primarily eliminated in urine .

Pregnancy & Breastfeeding use

Pregnancy Category C. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Contraindication

Hypersensitivity to aluminium salts.

Innovators Monograph

You find simplified version here Diovol