Dioxybenzone

Dioxybenzone Uses, Dosage, Side Effects, Food Interaction and all others data.

Dioxybenzone, or benzophenone-8, is an organic compound derived from Benzophenone that is used as a sunscreen agent. It absorbed UV-B and UV-AII rays. Dioxybenzone is an approved sunscreen ingredient in concentrations up to 3% .

Dioxybenzone is a sunscreen agent and chemical UV filter that absorbs UV-B rays and UV-AII rays to limit their penetration into human skin. In a screening protocol consisting of the in vitro EBV-EA activation assay followed by the in vivo confirmation test in the two-stage mouse skin cancer model utilizing NOR-1 as inducer and TPA as promoter of tumour, dioxybenzone exhibited a significant chemopreventive activity against mouse skin carcinogenesis which correlated with their antioxidant potency . There is some evidence that suggests some benzophenones and their hydroxylated metabolites act as weak estrogens in the environment; however similar effect of dioxybenzone has not been established .

Dioxybenzone
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Dioxybenzone
Generic	Dioxybenzone
Dioxybenzone Other Names	Dioxybenzone
Type
Formula	C₁₄H₁₂O₄
Weight	Average: 244.246 Monoisotopic: 244.073558866
Protein binding	No pharmacokinetic data available.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Dioxybenzone is a benzophenone derivative used in sunscreens to block UVB and short-wave UVA radiation.

Indicated for use as an active sunscreen agent.

Dioxybenzone is also used to associated treatment for these conditions: Sunburn

How Dioxybenzone works

Emitted by the sun, UVA-II rays, which range at 320–400 nm and are not absorbed by the ozone layer, and UVB rays, which range 290–320 nm and are partially absorbed by the ozone layer and exert a damaging effect on human skin, including basal cell carcinoma and melanoma . As a chemical filter, dioxybenzone absorb these rays to prevent their penetration into the skin and attenuate long-term skin damage caused by UV radiation from the sun. In a rat uterine cytosolic estrogen receptor (ER) competitive binding assay, dioxybenzone was not found to be a ER-binder .

Toxicity

No toxicokinetic data available.

Volume of Distribution

No pharmacokinetic data available.

Elimination Route

Dioxybenzone is a derivative of benzophenone. In monkeys, percutaneous absorption of benzophenone was observed . Other derivatives of benzophenone are capable of crossing the skin via direct penetration through the intercellular laminae of the stratum corneum (SC) or by passive diffusion by high-concentration gradient into the systemic circulation, where they are transported to different tissues including liver and brain .