Diphenidol
Diphenidol Uses, Dosage, Side Effects, Food Interaction and all others data.
Diphenidol is an antiemetic agent used in the treatment of vomiting and vertigo. Diphenidol overdose may result in serious toxicity in children.
Diphenidol is used for control of nausea and vomiting. It has an antivertigo effect on the vestibular apparatus, inhibiting the chemoreceptor trigger zone to control nausea and vomiting, thus preventing motion sickness.
| Trade Name | Diphenidol |
| Generic | Diphenidol |
| Diphenidol Other Names | Difenidol, Difénidol, Difenidolo, Difenidolum, Diphenidol |
| Type | Oral |
| Formula | C21H27NO |
| Weight | Average: 309.4452 Monoisotopic: 309.209264491 |
| Groups | Approved, Investigational, Withdrawn |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Diphenidol is an antiemetic agent used for the prevention and symptomatic treatment of nausea and vomiting associated with various conditions as Meniere's disease and surgery of the middle and inner ear.
For use in the prevention and symptomatic treatment of peripheral (labyrinthine) vertigo and associated nausea and vomiting that occur in such conditions as Meniere's disease and surgery of the middle and inner ear. Also for the control of nausea and vomiting associated with postoperative states, malignant neoplasms, labyrinthine disturbances, antineoplastic agent therapy, radiation sickness, and infectious diseases.
Diphenidol is also used to associated treatment for these conditions: Dizziness, Menière's Disease, Nausea, Postoperative, Prophylaxis against postoperative nausea and vomiting, Vomiting, Postoperative, Nausea, Postoperative
How Diphenidol works
The mechanism by which diphenidol exerts its antiemetic and antivertigo effects is not precisely known. It is thought to diminish vestibular stimulation and depress labyrinthine function and as an antimuscarinic agent. An action on the medullary chemoreceptive trigger zone may also be involved in the antiemetic effect. Diphenidol has no significant sedative, tranquilizing, or antihistaminic action. It has a weak peripheral anticholinergic effect.
Toxicity
Symptoms of overdose include drowsiness (severe); shortness of breath or troubled breathing; unusual tiredness or weakness (severe).
Food Interaction
No interactions found.Elimination Route
Well absorbed from gastrointestinal tract following oral administration.
Half Life
4 hours
Innovators Monograph
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