Diphtheria Conjugate

Diphtheria Conjugate Uses, Dosage, Side Effects, Food Interaction and all others data.

After reconstitution, 1 dose (0.5 ml) contains: Neisseria meningitidis group A polysaccharide 1 5 micrograms Neisseria meningitidis group C polysaccharide 1 5 micrograms Neisseria meningitidis group W-135 polysaccharide 1 5 micrograms Neisseria meningitidis group Y polysaccharide 1 5 micrograms Anti-capsular meningococcal antibodies protect against meningococcal diseases via complement mediated bactericidal activity. Diphtheria Conjugate induces the production of bactericidal antibodies against capsular polysaccharides of Neisseria meningitidis group A,C,W-135 and Y when measured by assays using either rSBA or hSBA.

Diphtheria Conjugate
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Diphtheria Conjugate
Generic	Meningococcal Conjugate Vaccine
Type	Intramuscular
Therapeutic Class	Vaccines, Anti-sera & Immunoglobulin
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Diphtheria Conjugate is used for active immunisation of individuals from the age of 6 weeks against invasive meningococcal diseases caused by Neisseria meningitidis group A, C, W-135, and Y.

Dosage

Diphtheria Conjugate dosage

Posology: Diphtheria Conjugate should be used in accordance with available official recommendations. Primary immunisation:

Infants from 6 weeks to less than 6 months of age: two doses, each of 0.5 ml, should be administered with an interval of 2 months between doses.
Infants from 6 months of age, children, adolescents and adults: a single 0.5 mL doseshould be administered.
An additional primary dose of Diphtheria Conjugate may be considered appropriate for some individuals.

Booster doses: After completion of the primary immunisation course in infants 6 weeks to less than 12 months of age, a booster dose should be given at 12 months of age with an interval of at least 2 months after the last Meningococcal Conjugate vaccination. In previously vaccinated individuals 12 months of age and older, Diphtheria Conjugate may be given as a booster dose if they have received primary vaccination with a conjugated or plain polysaccharide meningococcal vaccine.

Immunisation should be carried out by intramuscular injection only. In infants, the recommended injection site is the anterolateral aspect of the thigh. In individuals from 1 year of age, the recommended injection site is the anterolateral aspect of the thigh or the deltoid muscle. For instructions on reconstitution of the medicinal product before administration.

Side Effects

Adverse reactions are Appetite lost, Irritability, Insomnia, Crying, Drowsiness, Headache, Hypoaesthesia, Dizziness, Diarrhoea, Vomiting, Nausea, Pruritus, Rash, Myalgia, Pain in extremity, Fever, Swelling at injection site, Pain at injection site, Redness at injection site, Fatigue, Injection site haematoma, Malaise, Injection site induration, Injection site pruritus, Injection site warmth, Injection site anaesthesia

Interaction

In infants, Diphtheria Conjugate can be given concomitantly with combined DTaP-HBV-IPV/Hib vaccines and with 10-valent pneumococcal conjugate vaccine.
From age 1 year and above, Diphtheria Conjugate can be given concomitantly with any of the following vaccines: hepatitis A (HAV) and hepatitis B (HBV) vaccines, measles- mumps-rubella (MMR) vaccine, measles- mumps- rubella- varicella (MMRV) vaccine, 10-valent pneumococcal conjugate vaccine or unadjuvanted seasonal influenza vaccine.
In the second year of life, Diphtheria Conjugate can also be given concomitantly with combined diphtheria- tetanus- acellular pertussis (DTaP) vaccines, including combination DTaP vaccines with hepatitis B, inactivated poliovirus or Haemophilus influenzae type b (HBV, IPV or Hib) such as DTaP-HBV-IPV/Hib vaccine, and 13-valent pneumococcal conjugate vaccine.
In individuals aged 9 to 25 years, Diphtheria Conjugate can be given concomitantly with human papillomavirus bivalent [Type 16 and 18] vaccine, recombinant (HPV2).
Whenever possible, Diphtheria Conjugate and a TT containing vaccine, such as DTaP-HBV-IPV/Hib vaccine, should be co-administered or Diphtheria Conjugate should be administered at least one month before the TT containing vaccine.
One month after co-administration with a 10-valent pneumococcal conjugate vaccine, lower Geometric Mean antibody Concentrations (GMCs) and opsonophagocytic assay (OPA) antibody GMTs were observed for one pneumococcal serotype (18C conjugated to tetanus toxoid carrier protein). The clinical relevance of this observation is unknown.
There was no impact of co-administration on immune responses to the other nine pneumococcal serotypes.
One month after co-administration with a combined tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine, adsorbed (Tdap) in subjects aged 9 to 25 years, lower GMCs were observed to each pertussis antigen (pertussis toxoid [PT], filamentous haemagglutinin [FHA] and pertactin [PRN]). More than 98% of subjects had anti-PT, FHA or PRN concentrations above the assay cut-off thresholds. The clinical relevance of these observations is unknown. There was no impact of co-administration on immune responses to Diphtheria Conjugate or the tetanus or diphtheria antigens included in Tdap.
If Diphtheria Conjugate is to be given at the same time as another injectable vaccine, the vaccines should always be administered at different injection sites.
It may be expected that in patients receiving immunosuppressive treatment, an adequate response may not be elicited.

Pregnancy & Breastfeeding use

Pregnancy: There is limited experience with use of Diphtheria Conjugate in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryo/foetal development, parturition or post-natal development. Diphtheria Conjugate should be used during pregnancy only when clearly needed, and the possible advantages outweigh the potential risks for the foetus.

Breast-feeding: It is unknown whether Diphtheria Conjugate is excreted in human milk. Diphtheria Conjugate should only be used during breast-feeding when the possible advantages outweigh the potential risks.