Dipotassium Monophosphate
Dipotassium Monophosphate Uses, Dosage, Side Effects, Food Interaction and all others data.
Dipotassium Monophosphate (K2HPO4) is a highly water-soluble salt often used as a fertilizer and food additive as a source of phosphorus and potassium as well as a buffering agent.
Phosphate is a major intracellular anion which participates in providing energy for metabolism of substances and contributes to important metabolic and enzymatic reactions in almost all organs and tissues. Phosphate exerts a modifying influence on calcium concentrations, a buffering effect on acid-base equilibrium, and has a major role in the renal excretion of hydrogen ions.
| Trade Name | Dipotassium Monophosphate |
| Generic | Dipotassium phosphate |
| Dipotassium phosphate Other Names | Di-potassium hydrogen phosphate, Dibasic potassium phosphate, Dipotassium acid phosphate, Dipotassium hydrogen monophosphate, Dipotassium hydrogen orthophosphate, Dipotassium hydrogen phosphate, Dipotassium monophosphate, Kali phosphoricum, Potassium phosphate dibasic, Secondary potassium phosphate |
| Type | |
| Formula | HK2O4P |
| Weight | Average: 174.1759 Monoisotopic: 173.888658754 |
| Protein binding | Phosphate is minimally protein bound, and highly concentrated in cells (intracellular concentrations are 100-fold higher than serum concentrations). Concentrations of phosphate in plasma are higher in children than in adults. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Dipotassium Monophosphate is an ionic compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.
Dipotassium Monophosphate is used in imitation dairy creamers, dry powder beverages, mineral supplements, and starter cultures as an additive. It is used in non-dairy creamers to prevent coagulation. Dipotassium Monophosphate is also used to make buffer solutions and it is used in the production of trypticase soy agar which is used to make agar plates for culturing bacteria.
Dipotassium Monophosphate is also used to associated treatment for these conditions: Electrolyte imbalance, Mild Metabolic acidosis, Fluid replacement therapy, Parenteral rehydration therapy, Total parenteral nutrition therapy, Urine alkalinization therapy, Fluid and electrolyte maintenance
How Dipotassium Monophosphate works
Once phosphate gains access to the body fluids and tissues, it exerts little pharmacological effect. If the ion is introduced into the intestine, the absorbed phosphate is rapidly excreted. If large amounts are given by this route, much of it may escape absorption. Because this property leads to a cathartic action, phosphate salts are employed as mild laxatives.
Toxicity
LD50 not available. Toxic effects in humans: Irritated skin, eye. Gastro intestinal irritation with nausea, vomiting, diarrhea, abdominal discomfort
Food Interaction
No interactions found.Volume of Distribution
Distribution is largely intracellular, but it is the intravascular concentration that is primarily responsible for toxicity.
Elimination Route
Potassium salts are well absorbed from gastro intestinal tract. Net phosphorus absorption may occur in the small intestine in some species but is primarily a function of the colon in horses.
Half Life
In healthy children with phosphate overdose, half-life was 4.8 to 10.6 hours, and was prolonged to 17 hours in a child with renal insufficiency.
Clearance
Phosphates are rapidly cleared by dialysis.
Elimination Route
Potassium is excreted primarily by kidney.
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