Diprophylline
Diprophylline Uses, Dosage, Side Effects, Food Interaction and all others data.
Diprophylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis.
Diprophylline, a xanthine derivative, is a bronchodilator used for relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema. Diprophylline is a xanthine derivative with pharmacologic actions similar to theophylline and other members of this class of drugs. Its primary action is that of bronchodilation, but it also exhibits peripheral vasodilatory and other smooth muscle relaxant activity to a lesser degree.
| Trade Name | Diprophylline |
| Availability | Discontinued |
| Generic | Dyphylline |
| Dyphylline Other Names | Dihydroxypropyl theopylin, Diprofilina, Diprophylline, Diprophyllinum, Dyphylline |
| Related Drugs | Trelegy Ellipta, amoxicillin, prednisone, doxycycline, ciprofloxacin, azithromycin, ceftriaxone, levofloxacin, Symbicort, Breo Ellipta |
| Type | |
| Formula | C10H14N4O4 |
| Weight | Average: 254.2426 Monoisotopic: 254.101504956 |
| Protein binding | 84% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Diprophylline is a theophylline derivative used to treat asthma, bronchospasm, and COPD.
For relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema.
Diprophylline is also used to associated treatment for these conditions: Bronchial Asthma, Bronchospasm, Cheyne-Stokes Respiration
How Diprophylline works
The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic AMP producing relaxation of bronchial smooth muscle as well as antagonism of adenosine receptors.
Toxicity
LD50=1954 mg/kg (orally in mice)
Diprophylline Hypertension interaction
[Moderate] Like other methylxanthines, dyphylline at high dosages may be associated with positive inotropic and chronotropic effects on the heart.
Therapy with dyphylline and products containing dyphylline should be administered cautiously in patients with severe cardiac disease, hypertension, hyperthyroidism, or recent myocardial infarction.
The relationship between plasma dyphylline levels and therapeutic as well as toxic effects has not been determined.
Diprophylline Drug Interaction
Minor: clonazepam, clonazepamUnknown: azelastine nasal, azelastine nasal, acetaminophen / butalbital / caffeine, acetaminophen / butalbital / caffeine, cyclobenzaprine, cyclobenzaprine, fluticasone, fluticasone, ferrous sulfate, ferrous sulfate, escitalopram, escitalopram, atropine / diphenoxylate, atropine / diphenoxylate, gabapentin, gabapentin, acetaminophen, acetaminophen
Diprophylline Disease Interaction
Half Life
2 hours (range 1.8 - 2.1 hours)
Elimination Route
Diprophylline exerts its bronchodilatory effects directly and, unlike theophylline, is excreted unchanged by the kidneys without being metabolized by the liver. Approximately 88% of a single oral dose can be recovered from the urine unchanged.
Innovators Monograph
You find simplified version here Diprophylline
