Disodium ascorbyl phytostanol phosphates
Disodium ascorbyl phytostanol phosphates Uses, Dosage, Side Effects, Food Interaction and all others data.
Disodium ascorbyl phytostanol phosphates, is a novel hydrophilic phytostanol analogue representing a new class in cholesterol-lowering drugs called cholesterol absorption inhibitors. Disodium ascorbyl phytostanol phosphates has been shown to inhibit cholesterol absorption and to lower plasma LDL-cholesterol and total cholesterol in a broad range of animal species. Additional experiments suggest that Disodium ascorbyl phytostanol phosphates can reduce plasma LDL cholesterol levels and triglyceride levels, reduce weight gain and exert a anti-atherosclerosis effect.
FM VP4 is thought to bind competitively with cholesterol to MDR1 resulting in a synergistic decrease in cholesterol accumlation. Others have suggested that FM VP4 may act by inhibiting a transporter that mediates intestinal absorption of cholesterol.
| Trade Name | Disodium ascorbyl phytostanol phosphates |
| Generic | FM-VP4 |
| FM-VP4 Other Names | Disodium ascorbyl phytostanol phosphates |
| Type | |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in hyperlipidemia and cancer/tumors (unspecified).
Monotherapy is recommended for people with marginally high LDL-cholesterol or who cannot be prescribed statins due to drug interactions and safety concerns. Combination Therapy is recommended if statin therapy alone is either insufficient to achieve the guidelines set by the NCEP or there is concern over side effects as Statin doses can be lowered in combination treatment without losing efficacy.
How Disodium ascorbyl phytostanol phosphates works
FM VP4 is thought to bind competitively with cholesterol to MDR1 resulting in a synergistic decrease in cholesterol accumlation. Others have suggested that FM VP4 may act by inhibiting a transporter that mediates intestinal absorption of cholesterol. One study indicates that Disodium ascorbyl phytostanol phosphates inhibits cholesterol accumulation within IEC-6 cells and is most effective at equimolar concentrations with cholesterol, further suggesting that the action of Disodium ascorbyl phytostanol phosphates is likely at the cell surface and not elicited intracellularly.
Toxicity
Clinical trials have indicated that the drug is well-tolerated.
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