Disodium Hydrogenphosphate Uses, Dosage, Side Effects and more
Sodium phosphate inceases fecal water content to increase mobility through the large intestine .
| Trade Name | Disodium Hydrogenphosphate |
| Generic | Sodium phosphate, dibasic |
| Sodium phosphate, dibasic Other Names | Disodium acid phosphate, Disodium hydrogen monophosphate, Disodium hydrogen phosphate, disodium hydrogenphosphate, Disodium phosphate, Sodium phosphate dibasic, Sodium phosphate, dibasic |
| Type | |
| Formula | HNa2O4P |
| Weight | Average: 141.9588 Monoisotopic: 141.940784382 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Disodium Hydrogenphosphate is an osmotic laxative used to cleanse the colon before a colonoscopy.
Used to treat constipation or to clean the bowel before a colonoscopy .
Disodium Hydrogenphosphate is also used to associated treatment for these conditions: Constipation, Hypophosphatemia, Severe constipation, Total parenteral nutrition therapy
How Disodium Hydrogenphosphate works
Sodium phosphate is thought to work by increasing the amount of solute present in the intestinal lumen thereby creating an osmotic gradient which draws water into the lumen .
Toxicity
Intamuscular LD50 of 250mg/kg and oral LD50 of 8290 mg/kg reported in rats . Phosphate toxicity is likely due to the disturbance of other electrolytes when phosphate levels are high, producing symptoms including tetany, dehydration, hypotension, tachycardia, hyperpyrexia, cardiac arrest and coma . Risk of raising phosphate levels through use of sodium phosphate appears to be higher in smaller patients .
Food Interaction
- Take with a full glass of water.
- Take with food.
Elimination Route
Tmax for phosphate absorption with orally administered liquid sodium phosphate is 1-3h .
