Dithranol + Boric Acid + Salicylic Acid
Dithranol + Boric Acid + Salicylic Acid Uses, Dosage, Side Effects, Food Interaction and all others data.
প্রতি ১০০ গ্রাম অয়েন্টমেন্ট এ রয়েছে- ডাইথ্রানল বি.পি. ০.৭৫ গ্রাম বোরিক এসিড বি.পি. ১.৭৫ গ্রাম স্যালিসাইলিক এসিড বি.পি. ২.৫০ গ্রাম| Trade Name | Dithranol + Boric Acid + Salicylic Acid |
| Generic | Dithranol + Boric Acid + Salicylic Acid |
| Type | |
| Therapeutic Class | Dithranol & combined preparations |
| Manufacturer | |
| Available Country | Bangladesh |
| Last Updated: | September 24, 2024 at 5:38 am |
Uses
এই অয়েন্টমেন্ট নিন্মোক্ত উপসর্গে নির্দেশিত- দাদ কাউর সোরাইসিসDithranol + Boric Acid + Salicylic Acid is also used to associated treatment for these conditions: Acne, Asthenopia, Ocular Irritation, Skin Mycoses, Eye discomfort, Skin disinfection, Irrigation of the ocular surface therapyAcne, Actinic Keratosis (AK), Alopecia Areata (AA), Atopic Dermatitis (AD), Blackheads, Chronic Eczema, Chronic cutaneous lupus erythematosus, Corns, Dandruff, Dermatitis, Contact, Dermatitis, Eczematous, Dermatitis, Eczematous of the scalp, Discoid Lupus Erythematosus (DLE), Foot Callus, Fungal skin infection, Furuncle, Hand Eczema, Hyperkeratosis, Hyperkeratosis follicularis et parafollicularis, Infections, Fungal, Infections, Fungal of the Skin Folds, Infections, Fungal of the face, Infections, Fungal of the feet, Infections, Fungal of the hand, Keratosis Palmaris et Plantaris, Lichen, Lichen Plano-Pilaris, Lichen Planus (LP), Lichen simplex chronicus, Molluscum Contagiosum, Musculoskeletal Pain, Neurodermatitis, Palmo-Plantar Pustulosis, Plantar Warts, Pruritus, Psoriasis, Psoriasis Vulgaris (Plaque Psoriasis), Psoriasis of the scalp, Rash, Ringworm of the Skin, Ringworm of the scalp, Seborrheic Dermatitis, Seborrhoeic Dermatitis of the Scalp, Skin Infections, Bacterial, Verrucous Psoriasis, Warts, Calluses, Corticosteroid-responsive dermatoses, Keratinization disorders, Scaling, Scaling of skin, Scalp seborrhea, Superficial Fungal skin infection, Keratolysis
How Dithranol + Boric Acid + Salicylic Acid works
Information regarding the mechanism of action of boric acid in mediating its antibacterial or antifungal actions is limited. Boric acid inhibits biofilm formation and hyphal transformation of Candida albicans, which are critical virulence factors . In addition, arrest of fungal growth was observed with the treatment of boric acid .
Salicylic acid directly irreversibly inhibits COX-1 and COX-2 to decrease conversion of arachidonic acid to precursors of prostaglandins and thromboxanes. Salicylate's use in rheumatic diseases is due to it's analgesic and anti-inflammatory activity. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. Salicylic acid allows cells of the epidermis to more readily slough off. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. Salicylic acid is also used as an active ingredient in gels which remove verrucas (plantar warts). Salicylic acid competitively inhibits oxidation of uridine-5-diphosphoglucose (UDPG) with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG. It also competitively inhibits the transferring of the glucuronyl group of uridine-5-phosphoglucuronic acid (UDPGA) to a phenolic acceptor. Inhibition of mucopoly saccharide synthesis is likely responsible for the slowing of wound healing with salicylates.
Dosage
Dithranol + Boric Acid + Salicylic Acid dosage
ক্ষতস্থান গরম পানিতে খুব ভাল করে ধুয়ে ফেলুন। তারপর শুকনো ক্ষতস্থানে অল্প পরিমাণে মলম লাগিয়ে দিন (ক্ষতের বাইরে লাগাবেন না)। মলম দিনে একবার, প্রয়োজনবোধে বা চিকিৎসকের পরামর্শ অনুসারে দুইবার ক্ষত না সারা পর্যন্ত নিয়মিতভাবে ব্যবহার করুন। ক্ষত সেরে যাবার পর সম্পূর্ণভাবে আরোগ্য হওয়ার জন্য ৩-৪ দিন পর্যন্ত সামান্য পরিমাণ ব্যবহার করুন।Side Effects
The following is a list of possible side-effects that may occur from all constituting ingredients of this ointment. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away. Contact allergic reactions Irritation in skin areas surrounding treated lesions Soreness Temporary discoloration of hair and fingernails Mild cold or burning sensation at the site of application Severe allergic reaction Cardiovascular defects Skeletal variations Mild kidney lesions InfertilityToxicity
Acute oral LD50 is 2660 mg/kg in rat . Individuals are likely to be exposed to boric acid from industrial manufacturing or processing. Local tissue injury from boric acid exposure is likely due to caustic effects. Systemic effects from boric acid poisoning usually occur from multiple exposures over a period of days and involve gastrointestinal, dermal, CNS, and renal manifestations. Gastrointestinal toxicity include persistent nausea, vomiting, diarrhea, epigastric pain, hematemesis, and blue-green discoloration of the feces and vomit . Following the onset of GI symptoms, a characteristic intense generalized erythroderma follows . Management of mild to moderate toxicity should be supportive. In case of severe toxicity, dialysis may be required in addition to supportive treatment.
Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.
Precaution
ক্ষতস্থানের বাইরে স্বাভাবিক চর্মে এবং চোখ বা চোখের নিকটবর্তী স্থানে এই টপিক্যাল অয়েন্টমেন্ট ব্যবহার নিষেধ। এই মলমের কোন উপাদানের প্রতি সংবেদনশীলতা থাকলে এর ব্যবহার করা যাবে না। মলম ব্যবহারের পর ভাল করে হাত ধুয়ে ফেলতে হবে।Interaction
If you use other drugs or over the counter products at the same time, the effects of this ointment may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. this ointment may interact with the following drugs and products: Fluocinolone Hydroquinone Isotretinoin None reported Riboflavin TretinoinVolume of Distribution
Volume of distribution ranges from 0.17 to 0.5 L/kg in humans, where large amounts of boric acid are localized in brain, liver, and kidney .
The volume of distribution is about 170 mL/kg of body weight.
Elimination Route
Boric acid is well absorbed from the gastrointestinal tract, open wounds, and serous cavities but displays limited absorption in intact skin . Following intraperitoneal injection in mice, the peak concentration was reached in about 1.0-1.5 hr in the brain whereas the value was 0.5 hr in other tissues .
Half Life
According to human cases of poisoning, the elimination half-life of boric acid ranges from 13 to 24 hours .
Clearance
A case report of acute boric acid poisoning following oral ingestion of 21 g of boric acid presents the total body clearance of 0.99 L/h before hemodialysis .
Elimination Route
Regardless the route of administration, boric acid predominantly undergoes rapid renal excretion of >90% of total administered dose as unchanged form. Small amounts are also excreted into sweat, saliva, and feces. Following administration as ointment, urinary excretion of boric acid accounted for only 1% of the administered dose .
About 10% is excreted unchanged in the urine.
Pregnancy & Breastfeeding use
Not recommended during pregnancy. FDA has not yet classified the drug into a specified pregnancy category.Contraindication
Hypersensitivity to this ointment is a contraindication. In addition, this ointment should not be used if you have the following conditions: Acute or actively inflamed psoriatic eruptions After shaving or bathing Avoid use on dentures Breastfeeding Children Do not apply bandage or heating pad Facial psoriasis Genital warts Hypersensitivity Hypersensitivity to this drugSpecial Warning
Salicylic Acid is used in children over 2 years.
Acute Overdose
An overdose of Salicylic Acid topical is unlikely to occur. If you do suspect an overdose or if the medication has been ingested, call a poison control center or emergency room for advice.
Storage Condition
Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children.Innovators Monograph
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