Dixanol 320
Dixanol 320 Uses, Dosage, Side Effects, Food Interaction and all others data.
In concentrations of 270 and 320 mg of organically bound iodine per mL (550 mg and 642 ml of Dixanol 320 per mL)
Intravascular injection of iodixanol opacifies vessels in the path of flow of the contrast agent, permitting visualization of internal structures. In imaging of the body, iodinated contrast agents diffuse from the vascular into the extravascular space. In a normal brain with an intact blood-brain barrier, contrast does not diffuse into the extravascular space. In patients with a disrupted bloodbrain barrier, contrast agent accumulates in the interstitial space in the region of disruption.
Dixanol 320 is a contrast agent commonly used during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. It is an imaging contrast agent with the same osmolality as blood (290mOsm/kg H20).
Trade Name | Dixanol 320 |
Availability | Prescription only |
Generic | Iodixanol |
Iodixanol Other Names | Indixanol, Iodixanol, Iodixanolum |
Related Drugs | iohexol, barium sulfate, Omnipaque 350, Omnipaque 300, ioversol, Ultravist, Visipaque, Omnipaque 240, DaTscan, Volumen |
Weight | 652mg/ml |
Type | Injection |
Formula | C35H44I6N6O15 |
Weight | Average: 1550.1819 Monoisotopic: 1549.713275288 |
Protein binding | Negligible |
Groups | Approved |
Therapeutic Class | Contrast medium for diagnostic procedures |
Manufacturer | Techno Drugs Ltd |
Available Country | Bangladesh |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Dixanol 320 injection is a radiographic contrast agent used for the following:
Intra-arterial Procedures:
Adults and pediatric patients 12 years of age and over:
- Intra-arterial digital subtraction angiography (270 and 320 mg Iodine/mL).
- Angiocardiography (left ventriculography and selective coronary arteriography), peripheral arteriography, visceral arteriography, and cerebral arteriography (320 mg Iodine/mL).
Pediatric patients less than 12 years of age:
- Angiocardiography, cerebral arteriography, and visceral arteriography (320 mg Iodine/mL).
Intravenous Procedures:
Adults and pediatric patients 12 years of age and over:
- Computed tomography (CT) imaging head and body and excretory urography (270 and 320 mg Iodine/mL).
- CT imaging peripheral venography (270 mg Iodine/mL).
- Coronary computed tomography angiography (CCTA) to assist diagnostic evaluation of patients with suspected coronary artery disease (320 mg Iodine/mL).
Pediatric patients less than 12 years of age:
- CT imaging of the head and body and excretory urography (270 mg Iodine/mL).
How Dixanol 320 works
Organic iodine compounds attenuate x-rays as they pass through the body, thereby allowing the body structures containing iodine to be delineated in contrast to those structures that do not contain iodine. The degree of opacity produced by these compounds is directly proportional to the total amount (concentration and volume) of the iodinated contrast agent in the path of the x-rays. After intravascular administration, iodixanol makes opaque those internal structures in its path of flow, allowing their visualization until significant hemodilution and elimination occur.
Dosage
Dixanol 320 dosage
Individualize the combination of volume and concentration ofDixanol 320Injection considering age, body weight, size of the vessel, rate of blood flow within the vessel, and other applicable factors. For the adult patients, the maximum recommended total dose of iodine is 80 grams. Patients should be adequately hydrated prior to and following the intravascular administration of iodinated contrast agents.
Side Effects
Most common adverse reactions (incidence greater than 0.5%) in adult patients after Dixanol 320 injection: Discomfort, warmth, pain
Cardiovascular: angina. Gastrointestinal: diarrhea, nausea, vomiting.
Nervous System: agitation, anxiety, insomnia, nervousness, dizziness, headache, migraine, unusual skin sensations, sensory disturbance, fainting, sensation of spinning.
Skin: itchy rash, severe itching, hives.
Special Senses: Smell, taste, and vision alteration. Pediatric patients experienced similar adverse reactions.
Toxicity
Non-ionic radiocontrast agents like iodixanol are cytotoxic to renal cells. The toxic effects include apoptosis, cellular energy failure, disruption of calcium homeostasis, and disturbance of tubular cell polarity, and are thought to be linked to oxidative stress.
Precaution
Hypersensitivity Reactions: life-threatening or fatal reactions can occur. Always have emergency equipment and trained personnel available.
Contrast Induced Acute Kidney Injury: Acute injury including renal failure can occur. Minimize dose and maintain adequate hydration to minimize risk.
Cardiovascular reactions: hemodynamic disturbances including shock and cardiac arrest may occur during or after administration.
Food Interaction
No interactions found.Dixanol 320 Hypertension interaction
[Moderate] In patients with advanced renal disease, iodinated contrast media should be used with caution, and only when the need for the examination dictates, since the excretion of the medium may be impaired.
Patients with combined renal and hepatic disease, severe hypertension or congestive heart failure, and those with recent renal transplant may present an additional risk.
Dixanol 320 Drug Interaction
Unknown: charcoal, charcoal, sulfamethoxazole / trimethoprim, sulfamethoxazole / trimethoprim, ubiquinone, ubiquinone, copper gluconate, copper gluconate, ivabradine, ivabradine, sulfamethoxazole / trimethoprim, sulfamethoxazole / trimethoprim, glucose, glucose, diltiazem, diltiazem, sodium iodide, sodium iodide, acetaminophen, acetaminophen
Dixanol 320 Disease Interaction
Major: hyperthyroidism, pheochromocytomaModerate: sickle cell disease, multiple myeloma, myasthenia gravis, renal disease, allergies
Volume of Distribution
- 0.26 L/kg
Half Life
2.1 hours. In patients with significantly impaired renal function (mean creatinine clearance rate, 9.91 [± 3.58] mL per minute), the plasma half-life is increased to 23 hours.
Elimination Route
In adults, approximately 97% of the injected dose of iodixanol is excreted unchanged in urine within 24 hours, with less than 2% excreted in feces within five days post-injection.
Pregnancy & Breastfeeding use
Pregnancy:There are no data with iodixanol use in pregnant women to inform any drug-associated risks.
Lactation: A lactating woman may pump and discard breast milk for 10 hours after Dixanol 320 administration
Contraindication
Not indicated for intrathecal use
Special Warning
Geriatrics: Exercise caution in dose selection for elderly patients
Pediatric Use: The safety and efficacy of Dixanol 320 have been established in pediatric patients down to birth for angiocardiography, cerebral arteriography, visceral arteriography, CT imaging of the head and body, and excretory urography. The safety and efficacy of Dixanol 320 have also been established in pediatric patients 12 years and older for intra-arterial digital subtraction angiography, peripheral arteriography, CT imaging peripheral venography and CCTA.
Acute Overdose
The adverse effects of overdosage of any contrast agent may be life-threatening and affect mainly the pulmonary and cardiovascular systems. Treatment of an overdosage is directed toward the support of all vital functions and prompt institution of symptomatic therapy. Dixanol 320 Injection does not bind to plasma or serum protein and can be dialyzed.
Storage Condition
Store Dixanol 320 at controlled room temperature, 20°C-25°C; excursions permitted to 15°C-30°C
Innovators Monograph
You find simplified version here Dixanol 320
Dixanol 320 contains Iodixanol see full prescribing information from innovator Dixanol 320 Monograph, Dixanol 320 MSDS, Dixanol 320 FDA label