DNase I Uses, Dosage, Side Effects and more
DNase I (DNase I) is a human enzyme responsible for the digestion of extracellular DNA7. It is normally found in saliva, urine, pancreatic secretions, and blood. Because of the hypothesis that increased concentrations of high-molecular-weight DNA is a factor for airway obstruction, abnormal viscoelastic properties of the sputum, and recurrent exacerbations of respiratory symptoms requiring parenteral antibiotics, aerosolized human DNase I has been administered to patients with cystic fibrosis. Currently, DNase I is being investigated against respiratory failure in COVID-19 in the clinical trial NCT04541979 (Aerosoliserat DNase for Treatment of Respiratory Failure in Severe COVID-19).
| Trade Name | DNase I |
| Generic | Deoxyribonuclease I |
| Deoxyribonuclease I Other Names | DNase I |
| Type | |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
