Docusol Plus
Docusol Plus Uses, Dosage, Side Effects, Food Interaction and all others data.
Docusol Plus, an ester local anaesthetic, blocks the initiation and conduction of nerve impulses by decreasing the neuronal membrane’s permeability to Na ions, which results in inhibition of depolarisation with resultant blockade of conduction.
Docusol Plus is indicated for use as a topical anesthetic. It has a duration of action of approximately 10 minutes and a wide therapeutic window. Patients should be counselled regarding the risks of methemoglobinemia.
| Trade Name | Docusol Plus |
| Generic | Benzocaine |
| Benzocaine Other Names | Amben ethyl ester, Benzocaina, Benzocaine, Benzocainum, Ethyl aminobenzoate, Ethyl p-aminobenzoate, Ethyl p-aminophenylcarboxylate, p-(Ethoxycarbonyl)aniline, p-Carbethoxyaniline, p-Ethoxycarboxylic aniline |
| Type | |
| Formula | C9H11NO2 |
| Weight | Average: 165.1891 Monoisotopic: 165.078978601 |
| Protein binding | Benzocaine binds to both serum albumin and alpha-1-acid glycoprotein. |
| Groups | Approved, Investigational |
| Therapeutic Class | Local & Surface anesthesia |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the temporary relief of pain due to minor injury or irritation of the mouth and gums like Toothache, Sore gums, Canker sores, Braces, Minor dental procedures, Dentures
Docusol Plus is also used to associated treatment for these conditions: Acute Sore Throat Pain, Dental Pain, Gangrene Stomatitis, Gingivitis, Hemorrhoids, Laryngitis, Pharyngitis, Premature Ejaculation, Secondary Bacterial Infection caused by Tonsillectomy, Secondary Bacterial Infection caused by Tooth Extractions, Skin Irritation, Sore Throat, Stomatitis, Sunburn, Teething pain, Tonsillitis, Tooth Pain, Vomiting, Pruritic dermatosis, Ulceration of the mouth, Buccopharyngeal anesthesia
How Docusol Plus works
Docusol Plus diffuses into nerve cells where it binds to sodium channels, preventing the channels from opening, and blocking the influx of sodium ions. Nerve cells unable to allow sodium into cells cannot depolarize and conduct nerve impulses.
Dosage
Docusol Plus dosage
Apply to the affected area up to 4 times daily or as directed by a doctor/dentist. Children under 12 years of age should be supervised during the use of this product. Children under 2 years of age should be consulted to a doctor/dentist prior to the use of this product. An easy application might be done by fixing applicator on the tube’s nozzle. After application, supplied cap should be fixed on top of the applicator.
Side Effects
Side effects are less common. The side effects include allergies, swelling in the mouth or throatetc.
Toxicity
Patients experiencing an overdose may present with local anesthetic systemic toxicity syndrome, decreased cardiovascular function, decreased central nervous system function, cardiac arrest, bradycardia, hypotension, cardiac arrhythmias, syncope, and seizures. Patients should be treated with symptomatic and supportive measures which include airway maintenance, controlling seizures, and hemodynamic stabilization.
Precaution
Patient with asthma, bronchitis, emphysema, heart disease; smokers. Children, Pregnancy and lactation.
Interaction
May antagonise the therapeutic effect of sulfonamides. Anticholinesterases may inhibit the metabolism benzocaine.
Food Interaction
No interactions found.Pregnancy & Breastfeeding use
Pregnancy Category C. Either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus.
Contraindication
Epiglottis (oral spray), methaemoglobinaemia.
Acute Overdose
Symptom: Methaemoglobinaemia, manifested by cyanotic (greyish) skin discolouration, unusual breathing or breathlessness.
Management: Symptomatic and supportive treatment. IV methylene blue 1% may be administered.
Storage Condition
Store between 15-30° C.
Innovators Monograph
You find simplified version here Docusol Plus
Docusol Plus contains Benzocaine see full prescribing information from innovator Docusol Plus Monograph, Docusol Plus MSDS, Docusol Plus FDA label
FAQ
What is Docusol Plus used for?
Docusol Plus topical is used to reduce pain or discomfort caused by minor skin irritations, sore throat, sunburn, vaginal or rectal irritation, ingrown toenails, hemorrhoids, and many other sources of minor pain on a surface of the body. Docusol Plus is an ester local anesthetic commonly used as a topical pain reliever or in cough drops. It is the active ingredient in many over-the-counter anesthetic ointments such as products for oral ulcers.
How safe is Docusol Plus?
Docusol Plus topical used in the mouth may cause a condition in which the oxygen in your body tissues can become dangerously low. This is a potentially fatal condition called methemoglobinemia. Do not use Docusol Plus topical if you have ever had methemoglobinemia.
How does Docusol Plus work?
Docusol Plus works by blocking nerve signals in your body.
What are the common side effects of Docusol Plus?
Common side effects of Docusol Plus are include:
- Bluish-colored lips, fingernails, or palms.
- difficulty breathing.
- dizziness or lightheadedness.
- high fever.
- rapid heart rate.
- worsening of pain, redness, swelling, or irritation in or around the mouth.
Is Docusol Plus safe during pregnancy?
Docusol Plus topical is only recommended for use during pregnancy when benefit outweighs risk.
Is Docusol Plus safe during breastfeeding?
Docusol Plus has not been studied during breastfeeding, but is unlikely to affect her breastfed infant if it is applied away from the breast.
Can I drink alcohol with Docusol Plus?
Alcohol and Docusol Plus creates a that has different effects depending on the dose: many people feel stimulated and strengthened at low doses of alcohol and Docusol Plus and even mixing a small amount of Docusol Plus and alcohol is not recommended.
How often can I take Docusol Plus?
Do not use the Docusol Plus more than four times a day.
How should I use Docusol Plus topical?
Use exactly as directed on the label, or as prescribed by your doctor. Read all medication guides or instruction sheets. Your body may absorb more of benzocaine topical if you use too much, if you apply it over large skin areas, or if you apply heat, bandages, or plastic wrap to treated skin areas. Skin that is cut or irritated may also absorb more topical medication than healthy skin.
How long does Docusol Plus take to work?
Docusol Plus is a water-insoluble ester-type local anesthetic agent that is mainly useful for topical application. The onset of action is rapid (<1 minute), and the effective duration is 5 to 10 minutes.
What happens if I use Docusol Plus too much?
An overdose of Docusol Plus topical applied to the skin can cause life-threatening side effects such as uneven heartbeats, seizure (convulsions), coma, slowed breathing, or respiratory failure (breathing stops).
How much Docusol Plus is toxic?
The threshold toxic dose for Docusol Plus is 22-40 mg/kg.
Who should not take Docusol Plus?
Do not use benzocaine topical if you have ever had methemoglobinemia. Do not use Docusol Plus topical on a child younger than 2 years old.
What happens if I miss a dose?
Since Docusol Plus topical is used when needed, you may not be on a dosing schedule. Skip any missed dose if it's almost time for your next dose.
What what happen if I overdose?
Seek emergency medical attention. An overdose of benzocaine topical applied to the skin can cause life-threatening side effects such as uneven heartbeats, seizure (convulsions), coma, slowed breathing, or respiratory failure (breathing stops).
Will Docusol Plus affect my fertility?
Studies have not been done to see if Docusol Plus could affect male fertility or increase the chance of birth defects. In general, exposures that fathers or sperm donors have are unlikely to increase the risks to a pregnancy.
Can I drive after taking Docusol Plus ?
Docusol Plus does not affect your ability to drive.
Can Docusol Plus affects my liver?
Please consult your doctor if you have any concerns regarding the usage of Docusol Plus in patients with liver impairment.
Can Docusol Plus affects my kidney?
Please consult your doctor if you have any concerns regarding the usage of Docusol Plus in patients with kidney impairment.
Can I take Docusol Plus for a long time?
Docusol Plus should not be used for longer durations unless prescribed by a doctor. If your condition does not improve despite using Docusol Plus for a week, consult your doctor, he/she may prescribe you an alternate medicine.
Is It safe to use Docusol Plus on large areas of skin?
The topical form of Docusol Plus should not be used on large areas of skin, deep puncture wounds, raw or blistered skin, and on severe burns or abrasions. Use the smallest amount of Docusol Plus to numb the skin and to relieve pain.
Is Docusol Plus safe to treat mouth ulcers ?
Docusol Plus is used to treat mouth ulcers, canker sores and mouth irritation. Mouth ulcers, also known as canker sores are small, painful lesions which develop in the mouth or at the base of gums.
Can Docusol Plus be used for teething pain?
Docusol Plus should not be used to treat teething pain in infants.
can I eat after using Docusol Plus?
If you are using Docusol Plus for treating tooth pain, gum pain, or mouth ulcers, avoid eating within 1hour after using Docusol Plus. Docusol Plus numbs the skin; this might cause biting of the tongue. Avoid swallowing the topical form of Docusol Plus while applying it to your gums or inside the mouth.
