Dofacef

Dofacef Uses, Dosage, Side Effects, Food Interaction and all others data.

Dofacef is also known as cephamandole. It is a parenterally administered broad-spectrum cephalosporin antibiotic. It is generally formulated as a formate estercefamandole nafate. It is no longer marketed in the United States.

The parenteral prodrug formate ester cefamandole nafate is a broad-spectrum cephalosporin antibiotic. The bactericidal action of cefamandole results from inhibition of cell-wall synthesis. Cephalosporins have in vitro activity against a wide range of gram-positive and gram-negative organisms.

Dofacef
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Dofacef
Availability	Discontinued
Generic	Cefamandole
Cefamandole Other Names	Cefadole, Cefamandol, Céfamandole, Cefamandole, Cefamandolum, Cephadole, Cephamandole, L-Cefamandole
Related Drugs	amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin, Augmentin
Type	Injection
Formula	C₁₈H₁₈N₆O₅S₂
Weight	Average: 462.503 Monoisotopic: 462.078009096
Protein binding	75%
Groups	Approved, Experimental
Therapeutic Class
Manufacturer	Sanbe Farma
Available Country	Indonesia
Last Updated:	September 19, 2023 at 7:00 am

Uses

Dofacef is a beta-lactam antibiotic used in the treatment of various infections caused by susceptible strains of bacteria, such as lower respiratory infections, urinary tract infections, skin infections, and bone and joint infections.

For the treatment of serious infections caused by susceptible strains of microorganisms.

Dofacef is also used to associated treatment for these conditions: Gram-negative infections Bacterial Infections, Septic, Severe Bacterial Infections

How Dofacef works

Like all beta-lactam antibiotics, cefamandole binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefamandole interferes with an autolysin inhibitor.

Toxicity

Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting.

Food Interaction

Avoid alcohol. Ingesting alcohol with cefamandole may precipitate a disulfiram like reaction due to elevated levels of acetaldehyde in the blood.

Dofacef Alcohol interaction

[Moderate] GENERALLY AVOID:

Some cephalosporins may occasionally induce a disulfiram-like reaction when coadministered with alcohol.

The interaction has been reported for cefamandole, cefoperazone, cefotetan, and moxalactam.

These agents contain an N-methylthiotetrazole (NMTT) side chain that may inhibit aldehyde dehydrogenase (ALDH) similar to disulfiram.

Following ingestion of alcohol, inhibition of ALDH results in increased concentration of acetaldehyde, the accumulation of which produces an unpleasant physiologic response referred to as the 'disulfiram reaction'.

Symptoms include flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, weakness, vertigo, blurred vision, and confusion.

Severe reactions may result in respiratory depression, cardiovascular collapse, arrhythmias, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death.

Cefonicid contains a structurally similar side chain but did not produce elevations in blood acetaldehyde or a disulfiram reaction to ethanol in 15 healthy volunteers given single and multiple one gram doses of the drug.

Patients receiving cephalosporins with the NMTT side chain should avoid the concomitant use of alcohol and alcohol-containing products.

Dofacef Hypertension interaction

[Moderate] Parenteral cefamandole nafate is formulated with sodium carbonate to adjust the pH of the reconstituted solution and contains approximately 76 mg (3.3 mEq) of sodium per each gram of cefamandole activity.

The sodium content should be considered in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.