Domez
Domez Uses, Dosage, Side Effects, Food Interaction and all others data.
Domez is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.
Domez is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
| Trade Name | Domez |
| Generic | Domperidone |
| Domperidone Other Names | Domperidona, Domperidone, Domperidonum |
| Type | Capsule |
| Formula | C22H24ClN5O2 |
| Weight | Average: 425.911 Monoisotopic: 425.161852744 |
| Protein binding | 91%-93% |
| Groups | Approved, Investigational, Vet approved |
| Therapeutic Class | Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs |
| Manufacturer | Anvik Biotech |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Stimulation of gut motility in-
- Non-ulcer dyspepsia
- Oesophageal reflux, reflux oesophagitis and gastritis
- Diabetic gastroparesis
- Functional dyspepsia
- Speeding barium transit in follow through radiological studies
Prevention and symptomatic relief of acute nausea and vomiting from any cause including cytotoxic therapy, radiotherapy and antiparkinsonism therapy.
In the prophylactic treatment of migraine.
Domez is also used to associated treatment for these conditions: Diabetic Gastroparesis, Dyspepsia, Erosive Esophagitis, Gastrointestinal Symptoms, Non-erosive Reflux Esophagitis Disease (NERD), Upper gastrointestinal motility disorders
How Domez works
Domez acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Domez facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting
Dosage
Domez dosage
Adults: 10 - 20 mg every 4 - 8 hours daily
Children: 0.2 - 0.4 mg/kg every 4 - 8 hours daily.
Domez tablet and suspension should be taken 15 - 30 minutes before a meal. For acute nausea and vomiting, maximum period of treatment is 12 weeks.
Side Effects
Domez may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness and reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash and itching.
Toxicity
Side effects include galactorrhea, gynecomastia, or menstrual irregularities.
Precaution
Domez should be used with absolute caution in case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood brain barrier.
Interaction
Domez may reduce the hypoprolactinaemic effect of bromocriptine. Anti-muscarinics and opioid analgesics may antagonize the action of Domez on gastrointestinal function.
Food Interaction
- Take before a meal. Take 15-30 minutes before meals.
Half Life
7 hours
Pregnancy & Breastfeeding use
Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy.
Use in lactation: Domez may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.
Contraindication
Domez is contraindicated to the patients who have hypersensitivity to this drug and in case of neonates.
Acute Overdose
Overdose has been reported primarily in infants and children. Symptoms of overdosage may include disorientation, somnolence and extrapyramidal reactions. There is no specific antidote to domperidone, but in the event of overdose, the administration of activated charcoal may be useful. Anticholinergics, antiparkinson drugs may be useful in controlling extrapyramidal reactions. The patient should be observed closely and supportive measures employed.
Storage Condition
Store in a cool dry place protected from light. Keep out of reach of children.
Innovators Monograph
You find simplified version here Domez
Domez contains Domperidone see full prescribing information from innovator Domez Monograph, Domez MSDS, Domez FDA label
FAQ
What is Domez used for?
Domez help to stop feeling or being sick like as nausea or vomiting.It can also be used to treat stomach pain if you're having end of life care. Domez is sometimes used to increase milk supply.
Is Domez safe to take?
For most people, taking Domez is safe.If you have heart problems or are taking other medicines, you should first check with your healthcare professional that this medicine is appropriate.
What are the side effects of Domez?
Common side effects of Domez are include:
- swelling of the ankles/feet.
- unusual tiredness.
- mental/mood changes (e.g., nervousness, irritability)
- hot flashes.
- breast swelling/pain.
- unusual leakage of milk from the breast.
- changes in menstrual periods.
- decreased sexual ability.
Is Domezsafe during pregnancy?
Domez is not usually recommended in pregnancy.
Why Domez is not safe in pregnancy?
Domez is contraindicated for use in pregnant women and in women suspected of being pregnant, due to teratogenicity observed in reproductive toxicity studies.
Is Domez safe during breastfeeding?
A very small amount of the Domez you take can pass into your breast milk, but there is no record of harmful side effects in the baby from the mother taking Domez.
Can I drink alcohol with Domez?
It is best to avoid alcohol when taking Domez. Drinking alcohol can make side effects worse, such as sleepiness or an irregular heartbeat.
How long does Domez take to work?
Domez often takes at least three or four days before you notice any effect. It usually takes about two weeks to get a maximum effect, but some find it takes even longer.
Can I take Domez before bed?
Domez is best taken 15 to 30 minutes before meals and id necessary at bedtime.
Is Domez good for acid reflux?
It decreases postprandial reflux time and is therefore used to treat regurgitation and vomiting.
Can I take Domez after eating?
Domez is best taken about 15 to 30 minutes before meals, with a glass of water. If you take Domez after a meal, it will still work, but it may take longer to have an effect.
Is Domez good for gastritis?
Domez has a good advantage in the treatment of reflux gastritis and is more effective than conventional treatment.Domez is a kind of drug to strengthen gastric motility.
What does Domez do to your body?
Domez is a medicine that increases the movements or contractions of the stomach and bowel. Domez is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.
Is Domez safe for kidneys?
Domez are not significantly renally cleared and can be used in CKD.
Does Domez help anxiety?
Domez is used to treat severe anxiety like as emotional state where you may sweat, tremble, feel anxious and have a fast heartbeat or agitation.
Does Domez raise blood pressure?
Domez increases blood pressure and heart rate without inducing nocturnal hypertension in apomorphine treated patients with idiopathic Parkinson's disease.
Is Domez a narcotic?
Domez is not a controlled substance e.g. sleeping pills, valium, narcotics.
Does Domez cause depression?
Domez can cause central nervous system side effects such as fatigue, irritability, or depression.
Can I take Domez for a long time?
You should usually take Domez for up to a week.Because Domez can cause an irregular heartbeat if you take it for longer or at a high dose.
What happens when I stop taking Domez?
Most women do not experience discomfort when stopping the medication, gradual weaning from the medication will help the mother's milk supply to adjust without frustrating the baby or causing her discomfort. It is very important to stop the Domez slowly.
