Dompéridone Zydus
Dompéridone Zydus Uses, Dosage, Side Effects, Food Interaction and all others data.
Dompéridone Zydus is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.
Dompéridone Zydus is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
| Trade Name | Dompéridone Zydus |
| Generic | Domperidone |
| Domperidone Other Names | Domperidona, Domperidone, Domperidonum |
| Type | |
| Formula | C22H24ClN5O2 |
| Weight | Average: 425.911 Monoisotopic: 425.161852744 |
| Protein binding | 91%-93% |
| Groups | Approved, Investigational, Vet approved |
| Therapeutic Class | Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs |
| Manufacturer | |
| Available Country | France |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Stimulation of gut motility in-
- Non-ulcer dyspepsia
- Oesophageal reflux, reflux oesophagitis and gastritis
- Diabetic gastroparesis
- Functional dyspepsia
- Speeding barium transit in follow through radiological studies
Prevention and symptomatic relief of acute nausea and vomiting from any cause including cytotoxic therapy, radiotherapy and antiparkinsonism therapy.
In the prophylactic treatment of migraine.
Dompéridone Zydus is also used to associated treatment for these conditions: Diabetic Gastroparesis, Dyspepsia, Erosive Esophagitis, Gastrointestinal Symptoms, Non-erosive Reflux Esophagitis Disease (NERD), Upper gastrointestinal motility disorders
How Dompéridone Zydus works
Dompéridone Zydus acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Dompéridone Zydus facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting
Dosage
Dompéridone Zydus dosage
Adults: 10 - 20 mg every 4 - 8 hours daily
Children: 0.2 - 0.4 mg/kg every 4 - 8 hours daily.
Dompéridone Zydus tablet and suspension should be taken 15 - 30 minutes before a meal. For acute nausea and vomiting, maximum period of treatment is 12 weeks.
Side Effects
Dompéridone Zydus may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness and reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash and itching.
Toxicity
Side effects include galactorrhea, gynecomastia, or menstrual irregularities.
Precaution
Dompéridone Zydus should be used with absolute caution in case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood brain barrier.
Interaction
Dompéridone Zydus may reduce the hypoprolactinaemic effect of bromocriptine. Anti-muscarinics and opioid analgesics may antagonize the action of Dompéridone Zydus on gastrointestinal function.
Food Interaction
- Take before a meal. Take 15-30 minutes before meals.
Half Life
7 hours
Pregnancy & Breastfeeding use
Use in pregnancy: The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy.
Use in lactation: Dompéridone Zydus may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.
Contraindication
Dompéridone Zydus is contraindicated to the patients who have hypersensitivity to this drug and in case of neonates.
Acute Overdose
Overdose has been reported primarily in infants and children. Symptoms of overdosage may include disorientation, somnolence and extrapyramidal reactions. There is no specific antidote to domperidone, but in the event of overdose, the administration of activated charcoal may be useful. Anticholinergics, antiparkinson drugs may be useful in controlling extrapyramidal reactions. The patient should be observed closely and supportive measures employed.
Storage Condition
Store in a cool dry place protected from light. Keep out of reach of children.
Innovators Monograph
You find simplified version here Dompéridone Zydus
Dompéridone Zydus contains Domperidone see full prescribing information from innovator Dompéridone Zydus Monograph, Dompéridone Zydus MSDS, Dompéridone Zydus FDA label
FAQ
What is Dompéridone Zydus used for?
Dompéridone Zydus help to stop feeling or being sick like as nausea or vomiting.It can also be used to treat stomach pain if you're having end of life care. Dompéridone Zydus is sometimes used to increase milk supply.
Is Dompéridone Zydus safe to take?
For most people, taking Dompéridone Zydus is safe.If you have heart problems or are taking other medicines, you should first check with your healthcare professional that this medicine is appropriate.
What are the side effects of Dompéridone Zydus?
Common side effects of Dompéridone Zydus are include:
- swelling of the ankles/feet.
- unusual tiredness.
- mental/mood changes (e.g., nervousness, irritability)
- hot flashes.
- breast swelling/pain.
- unusual leakage of milk from the breast.
- changes in menstrual periods.
- decreased sexual ability.
Is Dompéridone Zydussafe during pregnancy?
Dompéridone Zydus is not usually recommended in pregnancy.
Why Dompéridone Zydus is not safe in pregnancy?
Dompéridone Zydus is contraindicated for use in pregnant women and in women suspected of being pregnant, due to teratogenicity observed in reproductive toxicity studies.
Is Dompéridone Zydus safe during breastfeeding?
A very small amount of the Dompéridone Zydus you take can pass into your breast milk, but there is no record of harmful side effects in the baby from the mother taking Dompéridone Zydus.
Can I drink alcohol with Dompéridone Zydus?
It is best to avoid alcohol when taking Dompéridone Zydus. Drinking alcohol can make side effects worse, such as sleepiness or an irregular heartbeat.
How long does Dompéridone Zydus take to work?
Dompéridone Zydus often takes at least three or four days before you notice any effect. It usually takes about two weeks to get a maximum effect, but some find it takes even longer.
Can I take Dompéridone Zydus before bed?
Dompéridone Zydus is best taken 15 to 30 minutes before meals and id necessary at bedtime.
Is Dompéridone Zydus good for acid reflux?
It decreases postprandial reflux time and is therefore used to treat regurgitation and vomiting.
Can I take Dompéridone Zydus after eating?
Dompéridone Zydus is best taken about 15 to 30 minutes before meals, with a glass of water. If you take Dompéridone Zydus after a meal, it will still work, but it may take longer to have an effect.
Is Dompéridone Zydus good for gastritis?
Dompéridone Zydus has a good advantage in the treatment of reflux gastritis and is more effective than conventional treatment.Dompéridone Zydus is a kind of drug to strengthen gastric motility.
What does Dompéridone Zydus do to your body?
Dompéridone Zydus is a medicine that increases the movements or contractions of the stomach and bowel. Dompéridone Zydus is also used to treat nausea and vomiting caused by other drugs used to treat Parkinson's Disease.
Is Dompéridone Zydus safe for kidneys?
Dompéridone Zydus are not significantly renally cleared and can be used in CKD.
Does Dompéridone Zydus help anxiety?
Dompéridone Zydus is used to treat severe anxiety like as emotional state where you may sweat, tremble, feel anxious and have a fast heartbeat or agitation.
Does Dompéridone Zydus raise blood pressure?
Dompéridone Zydus increases blood pressure and heart rate without inducing nocturnal hypertension in apomorphine treated patients with idiopathic Parkinson's disease.
Is Dompéridone Zydus a narcotic?
Dompéridone Zydus is not a controlled substance e.g. sleeping pills, valium, narcotics.
Does Dompéridone Zydus cause depression?
Dompéridone Zydus can cause central nervous system side effects such as fatigue, irritability, or depression.
Can I take Dompéridone Zydus for a long time?
You should usually take Dompéridone Zydus for up to a week.Because Dompéridone Zydus can cause an irregular heartbeat if you take it for longer or at a high dose.
What happens when I stop taking Dompéridone Zydus?
Most women do not experience discomfort when stopping the medication, gradual weaning from the medication will help the mother's milk supply to adjust without frustrating the baby or causing her discomfort. It is very important to stop the Dompéridone Zydus slowly.
