Dopril
Dopril Uses, Dosage, Side Effects, Food Interaction and all others data.
Perindopril is an ACE inhibitor. It works by blocking the action of angiotensin converting enzyme (ACE). ACE produces angiotensin II, as part of the body's natural control of blood pressure. Angiotensin II causes blood vessels to constrict and narrow, which increases the pressure within the blood vessels. Perindopril blocks the action of ACE, it reduces the production of angiotensin II, thus allows the blood vessels to relax and widen. The overall effect of this is a drop in blood pressure.
| Trade Name | Dopril |
| Generic | Perindopril Arginine |
| Weight | 2mg, 4mg |
| Type | Tablet |
| Therapeutic Class | Angiotensin-converting enzyme (ACE) inhibitors, Direct Renin Inhibitors |
| Manufacturer | Nova Med Pharmaceuticals |
| Available Country | Pakistan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Perindopril is a long-acting ACE (Angiotensin Converting Enzyme) inhibitor and is used for-
- Essential hypertension,
- Stable coronary artery disease,
- Congestive heart failure.
Dosage
Dopril dosage
Hypertension: One Perindopril 4 tablet once daily preferably in the morning. If necessary, the dose may be increased to 8 mg after 1 month of treatment. Perindopril should be taken before food.
Stable coronary artery disease: Perindopril 4 once daily for two weeks, then increased to 8 mg once daily, depending on renal function and provided that the 4 mg dose is well tolerated. Elderly patients should receive Perindopril 2 mg once daily for one week, then Perindopril 4 once daily the next week, before increasing the dose up to 8 mg once daily, depending on renal, function. The dose should be increased only if the previous lower dose is well tolerated.
Congestive heart failure: Perindopril should be started under close medical supervision at a starting dose of 2 mg in the morning. If necessary dose may be increased to 4 mg.
Elderly patients: Start at low daily dose (4 mg or less) and titrate slowly as needed. Experience with doses exceeding 8 mg is limited.
Side Effects
Rare and mild: usually at the start of treatment cough, fatigue, asthenia, headache, disturbances of mood and/or sleep have been reported.
Less often: Taste impairment, epigastric discomfort, nausea, abdominal pain and rash. Reversible increase in blood urea and creatinine may be observed. Proteinuria has occurred in some patients.
Rarely: Angioneurotic edema and decrease in hemoglobin, red cells and platelets have been reported.
Precaution
In the following cases, Perindopril should be used with caution:
- Renovascular hypertension
- Surgery/Anesthesia
- Renal failure: The dose should be cautiously adjusted in accordance with the creatinine clearance
- Symptomatic hypotension is rarely seen, but is more likely in volume-depleted patients, those receiving diuretics, or with the first two doses
- In diuretic-treated patients: stop the diuretic 3 days before starting Perindopril. A diuretic may later be given in combination if necessary; potassium-sparing diuretics are not recommended
- Combination with neuroleptics or imipramine-type drugs may increase the hypotensive effect. Serum lithium concentrations may rise during lithium therapy
Interaction
May enhance hypotensive effect with diuretics. Additive hyperkalaemic effect with K supplements, K-sparing diuretics, and other drugs (e.g. ciclosporin, heparin, indometacin). May increase serum levels and toxicity of lithium. Antihypertensive effect may be reduced by aspirin or other NSAIDs. Coadministration with NSAIDs may also increase the risk of renal impairment. Increased risk of hypoglycaemia with antidiabetic agents. Rarely, nitritoid reactions occur with concomitant use of gold (Na aurothiomalate).
Pregnancy & Breastfeeding use
Perindopril should not be used during pregnancy & lactation.
Contraindication
Perindopril is contraindicated in patients with a history of hypersensitivity to Perindopril. This drug is contraindicated in case of management of hypertension of Children, during Pregnancy & Lactation.
Storage Condition
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
Innovators Monograph
You find simplified version here Dopril
FAQ
What is Dopril used for?
Dopril is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.
How safe is Dopril?
Dopril can generally be used safely by the elderly. However, reduced kidney function is often found in the elderly and in this case, the starting dose should always be 2.5 mg. Perindopril arginine is not recommended for children.
How does Dopril work?
Dopril by blocking (inhibiting) a chemical called angiotensin-converting enzyme. This widens your blood vessels and helps to reduce the amount of water put back into your blood by your kidneys.
What are the common side effects of Dopril?
Common side effects of Dopril are include:
Is Dopril safe during pregnancy?
You are pregnant or become pregnant while taking Dopril, as it may cause serious harm to your baby.
Is Dopril safe during breastfeeding?
Limited information indicates that only low levels of Dopril and its active metabolite are found in breastmilk, which is consistent with other drugs in this class. Amounts ingested by the infant are small and would not be expected to cause any adverse effects in breastfed infants.
Can I drink alcohol with Dopril?
These products have a high content of potassium which could be harmful for you. If you drink alcohol, ask your doctor for advice about drinking alcohol while you are on Dopril. Alcoholic drinks may make you feel light-headed or dizzy, and may not be advisable for you.
When is the best time to take Dopril?
This is because the first dose can make you feel dizzy. After the first dose, take Dopril in the morning. Swallow the tablet with a drink of water. The ideal time to take your dose is 30-60 minutes before breakfast.
How much Dopril can I take?
4–8 mg taken once per day or split into two divided doses. Dosage increases: Your doctor may change your dosage based on your blood pressure. Maximum dosage: 16 mg per day.
How many hours does Dopril work?
Dopril is a significant contribution to the spectrum of drugs used in the treatment of hypertension because of its 24-hour effectiveness and very good tolerance.
How long does Dopril stay in my system?
Dopril 4–8 mg day−1 causes a persistent decrease in BP during the 24 h dosing interval, which is mostly maintained over the 24–48 h after dosing.
How long does Dopril stay in my system?
Dopril 4–8 mg day−1 causes a persistent decrease in BP during the 24 h dosing interval, which is mostly maintained over the 24–48 h after dosing.
Can I take Dopril for a long time?
Dopril oral tablet is used for long-term treatment. It comes with serious risks if you don't take it as prescribed. If you stop taking the drug suddenly or don't take it at all: Your high blood pressure will stay high. This may lead to serious complications, such as a heart attack or stroke.
Can I stop taking Dopril?
Stopping Dopril may cause your blood pressure to rise - and this may increase your risk of heart attack and stroke. If you're bothered by side effects, your doctor may be able to prescribe you a different medicine.
Who should not take Dopril?
You should not use Dopril if you have ever had angioedema. Do not take Dopril within 36 hours before or after taking medicine that contains sacubitril. If you have diabetes, do not use Dopril together with any medication that contains aliskiren (a blood pressure medicine).
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What are the common side effects of Dopril?
Common side effects of Dopril are include:
- dizziness
- weakness
- headaches
- upset stomach
- stomach pain
- diarrhea
- cough
- back pain
- low blood pressure, which may make you feel dizzy or faint
What happens if I take too much Dopril?
Dopril can cause a severe allergic reaction. Symptoms can include: trouble breathing. swelling of your throat or tongue.
Who should not take Dopril?
Do not use if you are pregnant. If you become pregnant, stop taking Dopril and tell your doctor right away. You should not use Dopril if you have ever had angioedema. Do not take Dopril within 36 hours before or after taking medicine that contains sacubitril. If you have diabetes, do not use perindopril together with any medication that contains aliskiren (a blood pressure medicine).
Can Dopril affects my heart ?
This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure.
Can Dopril affects my kidney?
Dopril may decrease how well your kidneys work. Your doctor may have you stop taking this drug if your kidney function gets worse while you're taking it.
Can Dopril affects my liver?
Dopril is associated with a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury.
