Dorevane
Dorevane Uses, Dosage, Side Effects, Food Interaction and all others data.
Dorevane, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, propiomazine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors.
Although propiomazine is a phenothiazine, it is not used as an antipsychotic. It posesses antihistamine effects and is mostly used as a sedative in treating insomnia.
| Trade Name | Dorevane |
| Availability | Discontinued |
| Generic | Propiomazine |
| Propiomazine Other Names | Propiomazin, Propiomazina, Propiomazine, Propiomazinum |
| Type | |
| Formula | C20H24N2OS |
| Weight | Average: 340.482 Monoisotopic: 340.16093409 |
| Protein binding | 81% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Dorevane is largely used for its antihistamininc sleep inducing effects in treating insomnia.
How Dorevane works
Dorevane acts as an antagonist of dopamine 1, 2, and 4 receptors, serotonin (5-HT) receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Its main use as a sedative is due to its antihistamine effect.
Toxicity
Although rare, serious adverse events may be seen with propiomazine. Such events include convulsions (seizures), difficult or unusually fast breathing, fast or irregular heartbeat or pulse, fever (high), high or low blood pressure, loss of bladder control, muscle stiffness (severe), unusual increase in sweating, unusually pale skin, and unusual tiredness or weakness.
Dorevane Alcohol interaction
[Moderate] GENERALLY AVOID:
Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.
Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines.
The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.
Patients should be advised to avoid alcohol during phenothiazine therapy.
Dorevane Drug Interaction
Moderate: hydroxyzine, aspirin / carisoprodol, methylphenidate, pregabalin, chlorzoxazone, methylphenidate, sertralineUnknown: aspirin, fluticasone / salmeterol, acetaminophen, calcium carbonate, calcium / vitamin d, ubiquinone, rosuvastatin, methylprednisolone, medroxyprogesterone, folic acid, adalimumab, ibuprofen, acetaminophen
Dorevane Disease Interaction
Innovators Monograph
You find simplified version here Dorevane
