Dorner

Dorner Uses, Dosage, Side Effects, Food Interaction and all others data.

Dorner is a synthetic analogue of prostacyclin, under clinical trials for the treatment of pulmonary hypertension. It is also being studied for use in avoiding reperfusion injury.

Dorner is a stable, orally active prostacyclin analogue with vasodilatory, antiplatelet and cytoprotective effects. Dorner is generally well tolerated and appears to be an effective agent in the treatment of patients with Buerger's disease and arteriosclerosis obliterans. Comparative data from a large randomised trial indicated that the drug appears as effective as ticlopidine in patients with these conditions. In patients with intermittent claudication, significant benefits of beraprost compared with placebo were reported in a randomised clinical trial; however, the use of beraprost in these patients is not supported by recent preliminary unpublished data from a large, phase III, placebo-controlled study. Limited data suggest some efficacy with long-term beraprost treatment of patients with PAH, where options are few and where oral administration of the drug could be a considerable advantage over intravenous prostacyclin (PGI2) therapy.

Dorner
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Dorner
Generic	Beraprost
Weight	20mcg.
Type	Tablet
Formula	C₂₄H₂₉NaO₅
Weight	Average: 420.4738 Monoisotopic: 420.191268713
Groups	Investigational
Therapeutic Class
Manufacturer	Toray Industries, Combiphar
Available Country	Indonesia
Last Updated:	September 19, 2023 at 7:00 am

Uses

For the treatment of pulmonary hypertension.

Dorner is also used to associated treatment for these conditions: Cystic Fibrosis (CF), Pain, Ulcers, Sensations of cold

How Dorner works

Dorner acts by binding to prostacyclin membrane receptors ultimately inhibiting the release of Ca²⁺ from intracellular storage sites. This reduction in the influx of Ca²⁺ has been postulated to cause relaxation of the smooth muscle cells and vasodilation.

Food Interaction

Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.