Dotatate Gallium Ga-68

Dotatate Gallium Ga-68 Uses, Dosage, Side Effects, Food Interaction and all others data.

Dotatate gallium (Ga-68) is a somatostatin-2 receptor analog which is radiolabeled with gallium 68 as a positron-emitting radioisotope. Ga-68 dotatate has a high affinity for somatostatin-2 receptor and it is rapidly excreted from the nontarget sites which gives it an ideal candidate for imaging neuroendocrine tumors. Dotatate gallium (Ga-68) explotes its ability to detect somatostatin receptor scintigraphy and this characteristic tends to change with tumor grade which gives Ga-68 dotate a high diagnostic value. Dotatate gallium 68 was developed by Advanced Accelerator Applications USA, Inc. and FDA approved in June 1, 2016.

The overexpression of somatostatin receptor in tumor tissue has been widely studied and the usage of scintigraphy for the diagnostic of neuroendocrine tumors has been happening since the beggining of the 90s. The development of positron-emission tomography there has been an emerging and growing field for the discovery of tracer labeled somatostatin analogues like dotatate gallium 68. Even after all the reportes, the pharmacodynamic profile of dotatate gallium 68 has not been studied.

Dotatate Gallium Ga-68
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Dotatate Gallium Ga-68
Generic	Dotatate gallium Ga-68
Dotatate gallium Ga-68 Other Names	(68Ga)Gallium dotatate, 68Ga-DOTATATE, 68Ga-DOTATOC, Dotatate gallium Ga-68, Ga 68 DOTATOC, Gallium (68Ga) DOTA-tate, Gallium (68Ga) dotatate, Gallium (Ga 68) dotatate, Gallium 68 dotatate, Gallium dotatate, Ga-68, Gatate
Type
Formula	C₆₅H₈₇GaN₁₄O₁₉S₂
Weight	Average: 1500.54 Monoisotopic: 1499.499317482
Protein binding	It presents binding to plasma proteins.
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Dotatate gallium 68 is one of the most prominent radiopharmaceuticals used in imaging with positron emission tomography. It binds to the somatostatin-2 receptor which is usually overexpressed in many neuroendocrine tumors in both adult and pediatric patients. The neuroendocrine tumors are bening or malignant tumors produced in the hormone producing cells of the neuroendocrine system.

Dotatate Gallium Ga-68 is also used to associated treatment for these conditions: Neuroendocrine Tumors

How Dotatate Gallium Ga-68 works

The somatostatin receptor-based imaging is the preferred choice in the diagnostic and management of neuroendocrine tumors. The basis for the mechanism of dotatate gallium 68 is the binding of a ligand analog that is radiolabeled, in this case thye preferred binding site is the receptors of the subtype 2. The malignant cells are reported to overexpress the somatostatin subtype 2 receptor. Dotatate gallium 68 is a β+ emiting radionuclide with an emission yield that can be detected by the positron emission tomography and thus the seletive binding to the overexpressed somatostatin receptor will be detected.

Toxicity

Studies on dotatate gallium 68 have not been studied but the comparative studies to other non-radioactivity compounds showed no mutation.

Volume of Distribution

The volume of distribution is registered in a range from 0.25-0.65 ml/cm3.

Elimination Route

Dotatate gallium 68 presents a higher affinity for the somatostatin receptor subtype 2 when compared with the other gallium 68 analogues. Intravenous administration of dotatate gallium 68 is absorbed and distributed to all the somatostatin subtype 2 receptor-containing organs like pituitary, thyroid, spleen, adrenals, kidney, pancreas, prostate, liver and salivary glands. There is no uptake in cerebral cortex or in the heart and the uptake presented in thymus and lung are very low.

Half Life

The half-life of gallium 68 is estimated to be of 68 min.

Clearance

The pharmacokinetics of dotatate gallium 68 is matched to the short half-life of the isotope gallium 68 thus, this pharmaceutical presents a very fast blood clearance.

Elimination Route

In the first four hours after the intravenous administration of dotatate gallium 68 there is an elimination of about 12% of the injected dose by the urine.