Doxapram hydrochloride
Doxapram hydrochloride Uses, Dosage, Side Effects, Food Interaction and all others data.
A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
Doxapram hydrochloride is an analeptic agent (a stimulant of the central nervous system). The respiratory stimulant action is manifested by an increase in tidal volume associated with a slight increase in respiratory rate. A pressor response may result following doxapram administration. Provided there is no impairment of cardiac function, the pressor effect is more marked in hypovolemic than in normovolemic states. The pressor response is due to the improved cardiac output rather than peripheral vasoconstriction. Following doxapram administration, an increased release of catecholamines has been noted.
| Trade Name | Doxapram hydrochloride |
| Availability | Prescription only |
| Generic | Doxapram |
| Doxapram Other Names | Doxapram, Doxapramum |
| Type | Injection |
| Formula | C24H30N2O2 |
| Weight | Average: 378.5072 Monoisotopic: 378.230728214 |
| Groups | Approved, Vet approved |
| Therapeutic Class | |
| Manufacturer | Synchrony Pharma Ltd |
| Available Country | United Kingdom |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Doxapram hydrochloride is a short acting respiratory stimulant used to treat acute respiratory insufficiency in COPD patients.
For use as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease.
Doxapram hydrochloride is also used to associated treatment for these conditions: Anesthetic complication pulmonary, Acute Hypercapnia, Drug-induced Respiratory depression, Postoperative respiratory depression, Post-operative respiratory stimulation
How Doxapram hydrochloride works
Doxapram hydrochloride produces respiratory stimulation mediated through the peripheral carotid chemoreceptors. It is thought to stimulate the carotid body by inhibiting certain potassium channels.
Toxicity
Intravenous LD50 values in the mouse and rat were approximately 75 mg/kg and in the cat and dog were 40 to 80 mg/kg. Symptoms of overdosage are extensions of the pharmacologic effects of the drug. Excessive pressor effect, tachycardia, skeletal muscle hyperactivity, and enhanced deep tendon reflexes may be early signs of overdosage.
Food Interaction
No interactions found.Doxapram hydrochloride Hypertension interaction
[Major] The use of CNS stimulants is contraindicated in patients with significant cardiovascular impairment such as uncompensated heart failure, severe coronary disease, severe hypertension (including that associated with hyperthyroidism or pheochromocytoma), cardiac structural abnormalities, serious arrhythmias, etc.
Sudden death has been reported in adults and children taking CNS stimulant treatment.
Additionally, stroke, myocardial infarction, chest pain, syncope, arrhythmias and other symptoms have been reported in adults under treatment.
A careful assessment of the cardiovascular status should be done in patients being considered for treatment.
This includes family history, physical exam and further cardiac evaluation (EKG and echocardiogram).
Patients who develop symptoms should have a detailed cardiac evaluation and if needed, treatment should be suspended.
Doxapram hydrochloride Drug Interaction
Moderate: fluticasone / salmeterol, fluticasone / salmeterol, umeclidinium / vilanterol, umeclidinium / vilanterol, formoterol / glycopyrrolate, formoterol / glycopyrrolateUnknown: zafirlukast, zafirlukast, ciclesonide, ciclesonide, RHO Immunoglobulin , RHO Immunoglobulin , mometasone, mometasone, lorazepam, lorazepam, ipratropium, ipratropium, ipratropium, ipratropium
Doxapram hydrochloride Disease Interaction
Major: cardiac disease, head injury, reactive airway disease, seizure disordersModerate: bipolar disorders, psychotic disorders, renal dysfunction
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