Doxapram hydrochloride

Doxapram hydrochloride Uses, Dosage, Side Effects, Food Interaction and all others data.

A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)

Doxapram hydrochloride is an analeptic agent (a stimulant of the central nervous system). The respiratory stimulant action is manifested by an increase in tidal volume associated with a slight increase in respiratory rate. A pressor response may result following doxapram administration. Provided there is no impairment of cardiac function, the pressor effect is more marked in hypovolemic than in normovolemic states. The pressor response is due to the improved cardiac output rather than peripheral vasoconstriction. Following doxapram administration, an increased release of catecholamines has been noted.

Trade Name Doxapram hydrochloride
Availability Prescription only
Generic Doxapram
Doxapram Other Names Doxapram, Doxapramum
Type Injection
Formula C24H30N2O2
Weight Average: 378.5072
Monoisotopic: 378.230728214
Groups Approved, Vet approved
Therapeutic Class
Manufacturer Synchrony Pharma Ltd
Available Country United Kingdom
Last Updated: September 19, 2023 at 7:00 am
Doxapram hydrochloride
Doxapram hydrochloride

Uses

Doxapram hydrochloride is a short acting respiratory stimulant used to treat acute respiratory insufficiency in COPD patients.

For use as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease.

Doxapram hydrochloride is also used to associated treatment for these conditions: Anesthetic complication pulmonary, Acute Hypercapnia, Drug-induced Respiratory depression, Postoperative respiratory depression, Post-operative respiratory stimulation

How Doxapram hydrochloride works

Doxapram hydrochloride produces respiratory stimulation mediated through the peripheral carotid chemoreceptors. It is thought to stimulate the carotid body by inhibiting certain potassium channels.

Toxicity

Intravenous LD50 values in the mouse and rat were approximately 75 mg/kg and in the cat and dog were 40 to 80 mg/kg. Symptoms of overdosage are extensions of the pharmacologic effects of the drug. Excessive pressor effect, tachycardia, skeletal muscle hyperactivity, and enhanced deep tendon reflexes may be early signs of overdosage.

Food Interaction

No interactions found.

Doxapram hydrochloride Hypertension interaction

[Major] The use of CNS stimulants is contraindicated in patients with significant cardiovascular impairment such as uncompensated heart failure, severe coronary disease, severe hypertension (including that associated with hyperthyroidism or pheochromocytoma), cardiac structural abnormalities, serious arrhythmias, etc.

Sudden death has been reported in adults and children taking CNS stimulant treatment.

Additionally, stroke, myocardial infarction, chest pain, syncope, arrhythmias and other symptoms have been reported in adults under treatment.

A careful assessment of the cardiovascular status should be done in patients being considered for treatment.

This includes family history, physical exam and further cardiac evaluation (EKG and echocardiogram).

Patients who develop symptoms should have a detailed cardiac evaluation and if needed, treatment should be suspended.

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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