Duogesic
Duogesic Uses, Dosage, Side Effects, Food Interaction and all others data.
Duogesic is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, anti-pyretic, and analgesic properties. It inhibits prostaglandin synthetase/cyclooxygenase, which limits prostaglandin production. Its cyclooxygenase inhibiting potency is intermediate, but is relatively selective for the cyclo-oxygenase-2 (COX-2) thus the potential for gastric injury and intolerance is less. It is also a free radical scavenger, and helps protect against the tissue damage that occurs during inflammation.
Food, gender and advanced age have negligible effects on nimesulide pharmacokinetics.
| Trade Name | Duogesic |
| Generic | Nimesulide |
| Nimesulide Other Names | Nimesulida, Nimesulide, Nimesulidum |
| Weight | 500mg + 30mg/15ml, 500mg + 30mg |
| Type | Tablet, Syrup, Oral Liquid, Oral Tablet |
| Formula | C13H12N2O5S |
| Weight | Average: 308.31 Monoisotopic: 308.046692194 |
| Protein binding | >97.5% |
| Groups | Approved, Investigational, Withdrawn |
| Therapeutic Class | Non-steroidal Anti-inflammatory Drugs (NSAIDs) |
| Manufacturer | Nitro Organics Pvt Ltd |
| Available Country | India, United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Duogesic is used for acute pain; extra-articular disorders; osteoarthritis; post-op pain; primary dysmenorrhoea
Duogesic is also used to associated treatment for these conditions: Menstrual Distress (Dysmenorrhea), Pain, Pain, Acute, NSAIDs
How Duogesic works
The therapeutic effects of Duogesic are the result of its complete mode of action which targets a number of key mediators of the inflammatory process such as: COX-2 mediated prostaglandins, free radicals, proteolytic enzymes and histamine.
Dosage
Duogesic dosage
100 mg twice daily.Should be taken with food. Take after meals.
Side Effects
Epigastric discomfort, heartburn or abdominal cramps, nausea, vomiting and diarrhoea; skin rash, pruritus, oedema, headache, dizziness, drowsiness; hypersensitivity reactions (e.g. bronchospasm, rhinitis, angioedema urticaria); GI haemorrhage/perforation; bullous/erosive stomatitis, purpura, thrombocytopenia, toxic epidermal necrolysis, haematuria, oliguria, and renal failure; increases in liver enzymes.
Toxicity
Oral TDLO (human): 1.429 mg/kg; Oral TDLO (woman): 2 mg/kg; Oral LD50 (rat): 200 mg/kg; Oral LD50 (mouse): 392 mg/kg
Precaution
History of GI tract disease, infections, oedema, hypertension, elderly, lactation.
Interaction
Additive hepatotoxic effects with known hepatotoxins: anti-convulsants (e.g. valproic acid), anti-fungals (e.g. ketoconazole), anti-tuberculous drugs (e.g. isoniazid), tacrine, pemoline, amiodarone, methotrexate, methyldopa, amoxicillin/clavulanic acid. May decrease the oral bioavailability of furosemide and the natriuretic and diuretic response to furosemide. Increased risks of GI and hepatic adverse effects with other NSAIDs, including aspirin. May increase anti-coagulant effect of warfarin. Potentiates the action of phenytoin. May be displaced from binding sites with fenofibrate, salicylic acid, and tolbutamide. Interactions between NSAIDs and lithium, probenecid and ciclosporin, have been documented.
Elimination Route
Rapidly absorbed following oral administration.
Half Life
1.8–4.7 hours
Elimination Route
Renal (50%), fecal (29%)
Pregnancy & Breastfeeding use
Category not classified
Contraindication
Hypersensitivity; GI bleeding, active peptic ulcer disease; severe renal and heart failure; hepatic impairment or known liver disease; coagulation disorders; pregnancy; children <12 yr.
Acute Overdose
Epigastric pain, nausea, vomiting, drowsiness, lethargy, GI haemorrhage, seizures, hypertension, apnoea, coma, anaphylactic reactions and renal failure. Treatment is supportive.
Storage Condition
Protect from heat and humidity; store at <25°C.
Innovators Monograph
You find simplified version here Duogesic
FAQ
What is Duogesic used for?
Duogesic is a medication used for pain relief and for the prevention of fever. Acute pain, pain due to menstrual cramps, backache, post-operative pain, osteoarthritis and fever are frequently prescribed.
how safe Duogesic is?
It is safer to use one with a favourable benefit-harm balance, such as ibuprofen, when a non-steroidal anti-inflammatory drug is required.The drug is best avoided in known or suspected liver disease; caution is warranted while prescribing nimesulide concomitantly with other hepatotoxic drugs.
What are the common side effect of Duogesic ?
Duogesic is generally well tolerated, but side effects can include headache, dizziness, somnolence, gastrointestinal upset, nausea, abdominal discomfort, diarrhea, peripheral edema and hypersensitivity reactions.
Is Duogesic bad for liver?
Duogesic must be withdrawn worldwide due to serious liver damage.Duogesic exposes patients to fatal liver damage.
How quickly does Duogesic work?
Duogesic works rapidly with immediate onset of action when taken orally. It can effectively reduce pain or fever within 15minutes of taking the medicine.
Is Duogesic safe during pregnancy?
Our study suggests that the use of Duogesic in early pregnancy may result in a greater risk of having births with congenital urinary tract anomalies.
Can I take Duogesic while breastfeeding?
The action of Duogesic on milk production for infants or the composition of milk is currently unknown. Some studies also suggest that Duogesic is unsafe for lactating women., lactating women are advised to take medical expert advice, take this drug with precautions, and avoid long-term use.
Can I take Duogesic safe with alcohol?
Avoid consuming alcohol while taking Duogesic as it can increase your risk of stomach problems.
Does bnrand increase blood pressure?
Our results indicate no difference between Duogesic and ketoprofen effects on mean blood pressure values during antihypertensive therapy.
Can Duogesic be taken empty stomach?
Do not take it on an empty stomach.Always take Duogesic together with food or immediately after a meal.
Is Duogesic safe for kidneys?
This observation indicates that Duogesic can provoke acute renal failure as a result of an obstructive crystalline nephropathy.
Can heart patients take Duogesic?
Duogesic should be used with great caution in patients with compromised renal function, cirrhosis of liver, congestive heart failure, renovascular disease, volume or salt depletion.
Is Duogesic good for headache?
Duogesic with Paracetamol is used for pain relief.
Is Duogesic used for migraine?
Duogesic has a well documented efficacy for relieving symptoms associated with migraine and non-migraine headaches.
Can Duogesic I take in periods?
Duogesic reduces the pressure during the maximal but not during the submaximal pain period, with concomitant alleviation of pain. The drug changes the painful state of uterine contracture to painless cyclic contractions.
Can Duogesic use for ear pain?
Duogesic indicate that the drug may be an effective and well tolerated therapy for painful inflammatory conditions of the ear, nose and throat.
Can Duogesic cause sleepiness?
Duogesic suspension overdose can make you drowsy (feeling sleepy).Generally suspension does not make you feel drowsy.
Can Duogesic be used for throat pain?
Duogesic which may be prescribed by your doctor to get rid of a sore throat and fever if you get these symptoms.
Is Duogesic safe for adults?
Duogesic may safe for adult if Duogesic recommended dose in 100 mg twice daily for no more than 15 days.
How bad is bnand?
Duogesic must be withdrawn worldwide due to serious liver damage.It exposes patients to fatal liver damage.
Can I take Duogesic for a long time?
Duogesic is not recommended long-term, as for chronic conditions such as arthritis. This is due to its association with an increased risk of liver toxicity, including liver failure.
Can I drive after taking Duogesic?
Duogesic may cause dizziness. If you feel dizzy, do not drive or take part in any activity in which you need to be alert.
