Durolane Pfs
Durolane Pfs Uses, Dosage, Side Effects, Food Interaction and all others data.
Sodium hyaluronate is a polysaccharide which functions as a tissue lubricant. It is widely used in ophthalmic surgery because it forms a viscoelastic solution in water which makes it a suitable substitute for aqueous and vitreous humour.
| Trade Name | Durolane Pfs |
| Generic | Sodium Hyaluronate |
| Type | Injection |
| Therapeutic Class | Drugs for Osteoarthritis |
| Manufacturer | Dr Reddys Laboratories Ltd |
| Available Country | India |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Durolane Pfs is used for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy, and to simple analgesics, e.g., acetaminophen.
Durolane Pfs is a viscous solution consisting of a high molecular weight fraction of purified natural sodium hyaluronate in buffered physiological sodium phosphate. It has a pH of 5.5-7.0. Hyaluronic acid is an important component of the body's extracellular matrix and is present in a particularly high concentration in cartilage and synovial fluid. Endogenous hyaluronic acid provides viscosity and elasticity to synovial fluid, which is fundamental for its lubricating and shock absorbing properties. It is essential for the correct structure of proteoglycans in articular cartilage. In osteoarthritis there is an insufficient amount of and a chance in the quality of hyaluronic acid in synovial fluid and cartilage. The intra-articular administration of hyaluronic acid into arthritic joints with degenerating cartilage surfaces and pathologically altered synovial fluid improved functions.
Dosage
Durolane Pfs dosage
Durolane Pfs is administered by intra-articular injection. A treatment cycle consists of five injections given at weekly intervals. Some patients may experience benefit with three injections given at weekly intervals. Inject the full 2 ml in one knee only. If treatment is bilateral, a separate injection should be used for each knee.
Side Effects
The common side-effects include gastrointestinal complaints, injection site pain, knee swelling/effusion, local skin reactions (rash, ecchymosis), pruritus, and headache.
Precaution
Use caution when injecting Durolane Pfs into patients who are allergic to avian proteins, feathers, and egg products. Strict aseptic administration technique must be followed. Remove joint effusion, if present, before injecting Durolane Pfs. Do not use the same syringe for removing joint effusion and for injecting Durolane Pfs. It is recommended that the patient avoid any strenuous activities or prolonged (i.e., more than 1 hour) weight-bearing activities such as jogging or tennis within 48 hours following the intra-articular injection.
Pregnancy & Breastfeeding use
The safety and effectiveness of Durolane Pfs have not been established in pregnant women. It is not known if Durolane Pfs is excreted in human milk. The safety and effectiveness of Durolane Pfs have not been established in lactating mother. The safety and effectiveness of Durolane Pfs have not been demonstrated in children.
Contraindication
The drug is contraindicated in patients with known hypersensitivity to hyaluronate preparations. Intra-articular injections are contraindicated in cases of past and present infections or skin diseases in the area of the injection site.
Acute Overdose
No case of over dosage has been reported to date.
Storage Condition
Hyronate injection should be stored in a cool (below 25° C) and dry place and protected from light. Protect from freezing.
Innovators Monograph
You find simplified version here Durolane Pfs
FAQ
What is Durolane Pfs used for?
Durolane Pfs topical skin medication is used to treat skin ulcers such as bed sores or diabetic foot ulcers, as well as burn wounds, surgical incisions, cuts, abrasions, and other skin irritations. Durolane Pfs skin medication is also used to treat dry or scaly skin.
How safe is Durolane Pfs?
Durolane Pfs as well as are considered safe. It's rarely associated with side effects when applied topically.
How does Durolane Pfs work?
Durolane Pfs works by pulling in moisture from the environment and the underlying layers of your skin into the epidermis.
What are the common side effects of Durolane Pfs?
The common side effects of Durolane Pfs are include:
- warmth, pain, redness, stiffness, bruising, or puffiness where the medicine was injected;
- nausea, stomach pain;
- trouble walking;
- swelling in your hands or feet;
- back pain, joint pain, muscle pain;
- numbness or tingly feeling;
- headache, dizziness; or
- runny or stuffy nose, sneezing, sore throat.
How is Durolane Pfs given?
Durolane Pfs is injected directly into your knee joint. A healthcare provider will give you this injection.
Durolane Pfs is usually given once every week for 3 to 5 weeks. Follow your doctor's dosing instructions very carefully.
Who should not take Durolane Pfs?
You should not receive a Durolane Pfs injection if you have an infection in your knee or in the skin around your knee.
Is Durolane Pfs safe during pregnancy?
Durolane Pfs also safe to use during pregnant.
Is Durolane Pfs safe during breastfeeding?
It is not known whether Durolane Pfs topical passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Is Durolane Pfs safe for skin?
Durolane Pfs are considered safe. It's rarely associated with side effects when applied topically.
How long take Durolane Pfs?
Durolane Pfs usually given once every week for 3 to 5 weeks.
How long does Durolane Pfs last?
Durolane Pfs lasts for about six months or longer in most people.
How much Durolane Pfs should I take?
Doses of 120–240 mg per day for at least one month have been shown to significantly increase skin moisture and reduce dry skin in adults.
Does Durolane Pfs have long term benefits?
Studies show that long term use is safe, with no reported side effects from Durolane Pfs supplementation. Used as a topical skincare ingredient, Durolane Pfs is also well tolerated.
Is it OK to use Durolane Pfs every day?
Yes, you can even use it twice a day as long as you're applying it to clean, damp skin, then locking it in with a moisturizer and face oil.
What happens if you use too much Durolane Pfs?
Too much Durolane Pfs can leave skin thirstier, and dehydration lines more prominent.
Does Durolane Pfs lighten dark spots?
Durolane Pfs can also minimize age spots and prevent any dark spots in the future on your skin.
Can Durolane Pfs dry skin?
Durolane Pfs is one of the most hydrating ingredients, but if misused,Durolane Pfs can actually dry out your skin.
Is Durolane Pfs good for pimples?
While Durolane Pfs can't fill in visible acne scars, it can help reduce redness and the visible appearance of acne.
Is Durolane Pfs good for wrinkles?
Durolane Pfs is well known for its skin benefits, especially alleviating dry skin, reducing the appearance of fine lines and wrinkles and speeding up wound healing.
Is Durolane Pfs good for hair?
You can use Durolane Pfs regardless of your hair type. It'll help your hair follicles lock in moisture.
Can I use Durolane Pfs under eyes?
Yes you can.Durolane Pfs can help mask darkness under the eyes.
What does Durolane Pfs do to your face?
Durolane Pfs helps reduce the visibility of fine lines and wrinkles retaining moisture to the skin.
Can Durolane Pfs cause facial hair growth?
Durolane Pfs is similar to a fertilizer because it can increase hair growth.
What happen If I missed Durolane Pfs?
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.
What happens if I overdose?
Durolane Pfs may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing.call a poison control center right away.
