DxPharma Neus Xylometazoline HCl

DxPharma Neus Xylometazoline HCl Uses, Dosage, Side Effects, Food Interaction and all others data.

DxPharma Neus Xylometazoline HCl is a sympathomimetic agent with marked alphaadrenergic activity, and is intended for use in the nose. It constricts the nasal blood vessels, thereby decongesting the mucosa of the nose and neighboring regions of the pharynx. This enables patients suffering from colds to breathe more easily through the nose. The effect of DxPharma Neus Xylometazoline HCl begins within a few minutes and persists for several hours. DxPharma Neus Xylometazoline HCl is generally well tolerated and does not impair the function of ciliated epithelium. Systemic absorption may occur following nasal application of DxPharma Neus Xylometazoline HCl.

DxPharma Neus Xylometazoline HCl is a sympathomimetic agent that causes vasoconstriction of the nasal mucosa. In one study comprising subjects with nasal congestion associated with the common cold, the median time of onset of subjective relief of nasal congestion was about 1.7 minutes and the time of subjective peak relief of nasal congestion was 30 minutes. Previous studies reported rebound swelling, rebound nasal congestion, rhinitis medicamentosa, and shorter duration of decongestant effect from the long-term use of xylometazoline in healthy volunteers, suggesting that the drug is most effective if used temporarily.

An early in vitro study demonstrated xylometazoline to exert anti-oxidant actions, where it inhibited microsomal lipid peroxidation and mediated hydroxyl radical scavenging activity. This suggests that xylometazoline has a beneficial effect against oxidants, which play a role in tissue damage in inflammation.

Trade Name DxPharma Neus Xylometazoline HCl
Generic Xylometazoline
Xylometazoline Other Names Xylometazoline, Xylometazolinum, Xylomethazoline
Type
Formula C16H24N2
Weight Average: 244.3752
Monoisotopic: 244.193948778
Protein binding

No information is available on xylometazoline pharmacokinetics.

Groups Approved, Investigational
Therapeutic Class Nasal Anti-histamine preparations
Manufacturer
Available Country Netherlands
Last Updated: September 19, 2023 at 7:00 am
DxPharma Neus Xylometazoline HCl
DxPharma Neus Xylometazoline HCl

Uses

For the symptomatic relief of nasal congestion, perennial allergic rhinitis (including hay fever), sinusitis.

DxPharma Neus Xylometazoline HCl is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Nasal Congestion, Seasonal Allergic Rhinitis

How DxPharma Neus Xylometazoline HCl works

Nasal congestion is caused by various etiologies, such as rhinosinusitis and allergic or non-allergic rhinitis, leading to congestion of the venous sinusoids lining the nasal mucosa. Activation of α-adrenergic receptors leads to vasoconstriction of the blood vessels of the nasal mucosa and resumption of nasal airflow. As the most abundantly expressed in the human nasal mucosa, α1A- and α2B-adrenoceptors may play the most important role in vasoconstriction of the human nasal mucosa. DxPharma Neus Xylometazoline HCl is a more selective agonist at α2B-adrenoceptors, with affinity at α1A-, α2A-, α2C-, α1B-, and α1D-adrenoceptors. DxPharma Neus Xylometazoline HCl decreases nasal resistance during inspiration and expiration and increases the volume of nasal airflow. Compared to oxymetazoline, another imidazoline nasal decongestant, xylometazoline had a slightly faster onset of action although they had a similar duration of action. In one study, subjects with nasal congestion reported relief of earache and sore throat in addition to nasal decongestion: it is speculated that oxymetazoline mediates this effect by causing vasoconstriction of the nasal mucosa that contains the venous sinuses and nasal decongestion allows breathing through the nose, providing relief from sore throat caused by mouth breathing that dries and irritates the throat.

Dosage

DxPharma Neus Xylometazoline HCl dosage

Adults: 2 or 3 drops of DxPharma Neus Xylometazoline HCl Adult formula (0.1%) two to three times daily. This adult formula should not be used for children under the age of 12 years.Children under 12 years: 1 or 2 drops of the DxPharma Neus Xylometazoline HCl children's formula (0.05%) in each nostril once or twice daily. Not to be used in infants less than 3 months.

Side Effects

The following side effects have occasionally been encountered: a burning sensation in the nose and throat, local irritation, nausea, headache, and dryness of the nasal mucosa. Systemic cardiovascular effects have occurred, and this should be kept in mind when giving DxPharma Neus Xylometazoline HCl to people with cardiovascular disease.

Toxicity

The oral LD50 is 230 mg/kg in rats and 75 mg/kg in mice. The subcutaneous LD50 is 90 mg/kg in rats and 53 mg/kg in mice. The intraperitoneal LD50 is 43 mg/kg in rats.

DxPharma Neus Xylometazoline HCl poisoning is documented in three pediatric patients who were exposed to a drug concentration 40 times above the adequate dosage for children due to a compounding error: these patients experienced bradypnea and sinus bradycardia with supraventricular extrasystoles and were managed with fluid management.

Precaution

Each DxPharma Neus Xylometazoline HCl pack should be used by one person only to prevent any cross-infection. Patients are advised not to take decongestants for more than seven consecutive days.

Interaction

No drug interactions have been reported.

Food Interaction

No interactions found.

Volume of Distribution

No information is available on xylometazoline pharmacokinetics.

Elimination Route

No information is available on xylometazoline pharmacokinetics.

Half Life

No information is available on xylometazoline pharmacokinetics.

Clearance

No information is available on xylometazoline pharmacokinetics.

Elimination Route

No information is available on xylometazoline pharmacokinetics.

Pregnancy & Breastfeeding use

No foetal toxicity or fertility studies have been carried out in animals. In view of its potential systemic vasoconstrictor effect, it is advisable to take the precaution of not using DxPharma Neus Xylometazoline HCl during pregnancy

Contraindication

DxPharma Neus Xylometazoline HCl nasal drops is contraindicated in patients with trans-sphenoidal hypophysectomy or surgery exposing the dura mater. It is also contraindicated in patients who are hypersensitive to DxPharma Neus Xylometazoline HCl.

Storage Condition

Protect from heat. For reasons of hygiene, do not use the bottle more than 28 days after opening it.

FAQ

What is xylometazoline used for?

bnrand used for temporary relief of congestion in the nose caused by various conditions including the common cold, sinusitis, hay fever, and allergies. It works by narrowing the blood vessels in the nose area, reducing swelling and congestion.

How safe DxPharma Neus Xylometazoline HCl is?

 Using too much of this DxPharma Neus Xylometazoline HCl can cause damage to your nasal passages, which may lead to chronic congestion.

What are the common side effects of DxPharma Neus Xylometazoline HCl ?

DxPharma Neus Xylometazoline HCl common side effects are include:

  • Nose irritation.
  • Sneezing.
  • Burning.
  • Tingling.
  • Runny nose.
  • Headache.
  • Dry nose.
  • Upset stomach.

Is DxPharma Neus Xylometazoline HCl safe during pregnancy?

You should only use DxPharma Neus Xylometazoline HCl during pregnancy if recommended by your doctor.

Is DxPharma Neus Xylometazoline HCl safe during breastfeeding?

DxPharma Neus Xylometazoline HCl are effective in relieving nasal congestion but do not produce wakefulness nor reduce milk supply.They are safe and effective but should not be used long term.

Can I drink alcohol with DxPharma Neus Xylometazoline HCl?

No interactions were found between Alcohol and DxPharma Neus Xylometazoline HCl. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

How long does DxPharma Neus Xylometazoline HCl stay in your system?

Long term use(> 10 days) is not recommended due to a rhinitis medicamentosa when stopped. bnrand is in the decongestant and alpha-adrenergic agonist families of medication.

Can I swallow DxPharma Neus Xylometazoline HCl?

Do not swallow the medication.DxPharma Neus Xylometazoline HCl nasal spray is only for use in the nose.

Does DxPharma Neus Xylometazoline HCl get me high?

An DxPharma Neus Xylometazoline HCl high isn't necessarily a strong high, but it does exist and can have severe consequences. If a person uses nasal sprays excessively, it can cause psychosis.

Does DxPharma Neus Xylometazoline HCl raise blood pressure?

 DxPharma Neus Xylometazoline HCl can also cause an increase in blood pressure.

Is DxPharma Neus Xylometazoline HCl a stimulant?

The most popular topical preparations contain DxPharma Neus Xylometazoline HCl , which have a long duration of action. Prolonged use can be associated with the risk of rebound congestion, so they can be recommended for occasional limited use for a few days only.

Does DxPharma Neus Xylometazoline HCl cause addiction?

DxPharma Neus Xylometazoline HCl have no chemicals these bad for your body, but they can also lead to addiction and recurring symptoms that worsen over time.

Can I take DxPharma Neus Xylometazoline HCl for a long time?

Children aged 6-12 years should not use DxPharma Neus Xylometazoline HCl for longer than five days at a time, but adults and children over 12 years of age can use it for up to seven days if needed.

How many days can I use DxPharma Neus Xylometazoline HCl?

Do not use DxPharma Neus Xylometazoline HCl nasal spray for longer than 3 days. If your symptoms do not get better after 3 days of treatment, stop using DxPharma Neus Xylometazoline HCl and call your doctor.

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*** Taking medicines without doctor's advice can cause long-term problems.
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