Dysmen Tablet 250 mg
Dysmen Tablet 250 mg Uses, Dosage, Side Effects, Food Interaction and all others data.
Dysmen Tablet 250 mg, an anthranilic acid derivative, is a prototypical NSAID. It reversibly inhibits the cyclooxygenase-1 and cyclooxygenase-2 (COX-1 and COX-2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors. It has analgesic and antipyretic properties with minor anti-inflammatory activity.
Dysmen Tablet 250 mg, an anthranilic acid derivative, is a member of the fenamate group of nonsteroidal anti-inflammatory drugs (NSAIDs). It exhibits anti-inflammatory, analgesic, and antipyretic activities. Similar to other NSAIDs, mefenamic acid inhibits prostaglandin synthetase.
| Trade Name | Dysmen Tablet 250 mg |
| Generic | Mefenamic acid |
| Mefenamic acid Other Names | Acide méfénamique, ácido mefenámico, Acidum mefenamicum, Mefenamic acid, Mefenaminsäure |
| Weight | 250 mg |
| Type | Tablet |
| Formula | C15H15NO2 |
| Weight | Average: 241.2851 Monoisotopic: 241.110278729 |
| Protein binding | 90% |
| Groups | Approved |
| Therapeutic Class | Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs) |
| Manufacturer | Renata Limited |
| Available Country | Bangladesh |
| Last Updated: | October 19, 2023 at 6:27 am |
Uses
Dysmen Tablet 250 mg is used in mild to moderate pain including headache, dental pain, postoperative and postpartum pain, dysmenorrhoea, menorrhagia, in musculoskeletal and joint disorders such as osteoarthritis and rheumatoid arthritis; and in children with fever and juvenile idiopathic arthritis.
Dysmen Tablet 250 mg is also used to associated treatment for these conditions: Mild pain, Primary Dysmenorrhoea, Gastrointestinal cramps, Moderate Pain
How Dysmen Tablet 250 mg works
Dysmen Tablet 250 mg binds the prostaglandin synthetase receptors COX-1 and COX-2, inhibiting the action of prostaglandin synthetase. As these receptors have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity, the symptoms of pain are temporarily reduced.
Dosage
Dysmen Tablet 250 mg dosage
As with other NSAIDs, the lowest dose should be sought for each patient. Therefore, after observing the response to initial therapy with Dysmen Tablet 250 mg, the dose and frequency should be adjusted to suit an individual patient's needs.Administration is by the oral route, preferably with food.
- Adult: A 500 mg dose should be given to adults up to three times (1.5 g total) per day.
- Infants over 6 months: 25 mg/kg of body weight daily in divided doses for not longer than 7 days.
Side Effects
In patients taking Dysmen Tablet 250 mg or other NSAIDs, the most frequently reported adverse experiences include : abdominal pain, constipation, diarrhoea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea, GI ulcers, vomiting, abnormal renal function, anaemia, dizziness, oedema, elevated liver enzymes, headache, increased bleeding time, pruritus, rash and tinnitus.
Toxicity
Oral, rat LD50: 740 mg/kg. Symptoms of overdose may include severe stomach pain, coffee ground-like vomit, dark stool, ringing in the ears, change in amount of urine, unusually fast or slow heartbeat, muscle weakness, slow or shallow breathing, confusion, severe headache or loss of consciousness.
Precaution
NSAIDs should be prescribed with extreme caution in those with a prior history of ulcer disease or gastrointestinal bleeding. To minimise the potential risk for an adverse GI event, the lowest effective dose should be used for the shortest possible duration. In cases with pre-existing advanced kidney disease, treatment with Dysmen Tablet 250 mg is not recommended.
Interaction
Concomitant use with CYP2C9 isoenzyme inhibitors may alter safety and efficacy of mefenamic acid. May enhance methotrexate toxicity. Reduced BP response to ACE inhibitors or angiotensin II receptor antagonists. Increased risk of serious GI events with aspirin. May reduce the natriuretic effects of furosemide or thiazide diuretics. Reduced renal lithium clearance and elevated plasma lithium levels. May enhance anticoagulant effect of warfarin.
Food Interaction
- Avoid alcohol.
- Take with food.
Volume of Distribution
- 1.06 L/kg [Normal Healthy Adults (18-45 yr)]
Elimination Route
Dysmen Tablet 250 mg is rapidly absorbed after oral administration.
Half Life
2 hours
Clearance
- Oral cl=21.23 L/hr [Healthy adults (18-45 yrs)]
Elimination Route
The fecal route of elimination accounts for up to 20% of the dose, mainly in the form of unconjugated 3-carboxymefenamic acid.3 The elimination half-life of mefenamic acid is approximately two hours. Dysmen Tablet 250 mg, its metabolites and conjugates are primarily excreted by the kidneys. Both renal and hepatic excretion are significant pathways of elimination.
Pregnancy & Breastfeeding use
Pregnancy: In late pregnancy, as with other NSAIDs, Dysmen Tablet 250 mg should be avoided because it may cause premature closure of the ductus arteriosus. In general there are no adequate and well controlled studies in pregnant women. Dysmen Tablet 250 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. Rated as Pregnancy Category C.
Lactation: Trace amounts of Dysmen Tablet 250 mg may be present in breast milk. Taking into account the importance of the drug to the mother , decision should be made whether to discontinue nursing or to discontinue the drug.
Contraindication
Dysmen Tablet 250 mg is contraindicated in patients with known hypersensitivity to Me Dysmen Tablet 250 mg acid. Dysmen Tablet 250 mg should not be given to patients who have experienced asthma, urticaria, or allergic type reactions after taking aspirin or other NSAIDs. Rarely fatal, anaphylactic like reactions to NSAIDs have been reported in such patients. Dysmen Tablet 250 mg is contraindicated in patients with active ulceration or chronic inflammation of upper gastrointestinal tract and should not be used in patients with preexisting renal disease.
Acute Overdose
Symptoms: Headache, nausea, vomiting, epigastric pain, GI bleeding. Rarely, diarrhoea, disorientation, excitation, coma, drowsiness, tinnitus, fainting, and occasionally convulsions.
Management: Symptomatic and supportive treatment. In acute overdosage, empty the stomach immediately by inducing emesis or by gastric lavage followed by admin of activated charcoal.
Storage Condition
Store between 20-25° C.
Innovators Monograph
You find simplified version here Dysmen Tablet 250 mg
Dysmen Tablet 250 mg contains Mefenamic acid see full prescribing information from innovator Dysmen Tablet 250 mg Monograph, Dysmen Tablet 250 mg MSDS, Dysmen Tablet 250 mg FDA label
FAQ
What is Dysmen Tablet 250 mg used for?
Dysmen Tablet 250 mg is used short-term to treat mild to moderate pain in adults and children who are at least 14 years old.
How safe is Dysmen Tablet 250 mg?
Dysmen Tablet 250 mg may increase your risk of heart problems, including heart attack, stroke, heart failure, or blood clot. These conditions can be fatal. Your risk may increase if you already have heart disease or have taken the medication for a long period of time or at high doses.
How does Dysmen Tablet 250 mg work?
Dysmen Tablet 250 mg works by stopping the body's production of a substance that causes pain, fever, and inflammation.
What are the common side effects of Dysmen Tablet 250 mg?
Common side effects of Dysmen Tablet 250 mg are include:
- diarrhea.
- constipation.
- gas or bloating.
- headache.
- dizziness.
- nervousness.
- ringing in the ears
Is Dysmen Tablet 250 mg safe during pregnancy?
Use of Dysmen Tablet 250 mg during pregnancy is not advised unless prescribed by a doctor, especially if you are 30 or more weeks pregnant.
Is Dysmen Tablet 250 mg safe during breastfeeding?
Dysmen Tablet 250 mg passes into breast milk and is not recommended for use while breastfeeding.
Can I drink alcohol with Dysmen Tablet 250 mg?
Do not drink alcohol while taking Dysmen Tablet 250 mg. Alcohol can increase your risk of stomach bleeding caused by Dysmen Tablet 250 mg. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines.
Can I drive after taking Dysmen Tablet 250 mg?
Dysmen Tablet 250 mg Tablets may cause drowsiness, fatigue, dizziness or may affect your vision. If you experience any of these symptoms, you should not drive or operate machinery, or perform any tasks which may require you to be alert.
When should be taken of Dysmen Tablet 250 mg?
Dysmen Tablet 250 mg is usually taken with food every 6 hours as needed for up to 1 week.
Is it safe to take Dysmen Tablet 250 mg?
Dysmen Tablet 250 mg should not be used for longer than 7 days.
How many times can I take Dysmen Tablet 250 mg?
Dysmen Tablet 250 mg take 250 mg every six hours as needed. You shouldn't take Dysmen Tablet 250 mg for longer than three days.
How long does Dysmen Tablet 250 mg take to work?
If you wait until the symptoms have worsened,Dysmen Tablet 250 mg may not work as well. If you are using Dysmen Tablet 250 mg for painful periods, take your first dose as soon as your period starts or pain begins. Usually, you will only need to take it for the first 2 to 3 days of your period.
How long does it take for Dysmen Tablet 250 mg to kick in?
Dysmen Tablet 250 mg takes between 2 - 4 hours to kick in and start easing your period pain. Each 500mg dose of Dysmen Tablet 250 mg kills pain for up to 8 hours, so you may need to take it two or three times a day for all-day relief.
Can I take Dysmen Tablet 250 mg for a long time?
Dysmen Tablet 250 mg should not be used for longer than 7 days. Follow your doctor's dosing instructions very carefully. If you use Dysmen Tablet 250 mg long-term, you may need frequent medical tests.Dysmen Tablet 250 mg can cause unusual results with certain medical tests.
Who should not take Dysmen Tablet 250 mg?
Dysmen Tablet 250 mg can increase your risk of fatal heart attack or stroke. Do not use Dysmen Tablet 250 mg just before or after heart bypass surgery .Dysmen Tablet 250 mg may also cause stomach or intestinal bleeding, which can be fatal.
What happens if I miss a dose on Dysmen Tablet 250 mg?
Take Dysmen Tablet 250 mg as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happen if I take too much Dysmen Tablet 250 mg?
If you take too much If you take too much Dysmen Tablet 250 mg, you may experience: drowsiness, nausea,vomiting.
When can I stop taking Dysmen Tablet 250 mg?
If you experience any of the following symptoms, stop taking Dysmen Tablet 250 mg and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.
Can Dysmen Tablet 250 mg affects my heart ?
Dysmen Tablet 250 mg can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease.
