(E)-resveratrol

(E)-resveratrol Uses, Dosage, Side Effects, Food Interaction and all others data.

(E)-resveratrol (3,5,4'-trihydroxystilbene) is a polyphenolic phytoalexin. It is a stilbenoid, a derivate of stilbene, and is produced in plants with the help of the enzyme stilbene synthase. It exists as cis-(Z) and trans-(E) isomers. The trans- form can undergo isomerisation to the cis- form when heated or exposed to ultraviolet irradiation. In a 2004 issue of Science, Dr. Sinclair of Harvard University said resveratrol is not an easy molecule to protect from oxidation. It has been claimed that it is readily degraded by exposure to light, heat, and oxygen. However, studies find that Trans-resveratrol undergoes negligible oxidation in normal atmosphere at room temperature.

(E)-resveratrol, a phytoalexin, has been found to inhibit herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) replication in a dose-dependent, reversible manner, although this is only one of its many pharmaceutical properties. In some countries where there is higher consumption of red wine, there appears to be a lower incidence of heart disease. Other benefits of resveratrol include its anti-inflammatory and antioxidant effects. In preclinical studies, (E)-resveratrol has been found to have potential anticancer properties.

(E)-resveratrol
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Dosage
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	(E)-resveratrol
Generic	Resveratrol
Resveratrol Other Names	(E)-resveratrol, 3,4',5-trihydroxystilbene, trans-resveratrol
Type
Formula	C₁₄H₁₂O₃
Weight	Average: 228.2433 Monoisotopic: 228.07864425
Protein binding	Strong affinity towards protein binding.
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Being investigated for the treatment of Herpes labialis infections (cold sores).

How (E)-resveratrol works

(E)-resveratrol suppresses NF-kappaB (NF-kappaB) activation in HSV infected cells. Reports have indicated that HSV activates NF-kappaB during productive infection and this may be an essential aspect of its replication scheme [PMID: 9705914].