Echodide
Echodide Uses, Dosage, Side Effects, Food Interaction and all others data.
A potent, long-acting irreversible cholinesterase inhibitor used as an ocular hypertensive in the treatment of glaucoma. Occasionally used for accomodative esotropia.
Echodide Iodide is a potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma. Echodide iodide will depress both plasma and erythrocyte cholinesterase levels in most patients after a few weeks of eyedrop therapy.
| Trade Name | Echodide |
| Availability | Prescription only |
| Generic | Echothiophate |
| Echothiophate Other Names | Echothiophate, Ecothiopate, Ecothiopatum, Phospholine |
| Related Drugs | acetazolamide, nadolol, pilocarpine ophthalmic, Diamox, Combigan, mitomycin ophthalmic |
| Type | |
| Formula | C9H23NO3PS |
| Weight | Average: 256.323 Monoisotopic: 256.113625809 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Echodide is an acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma.
For use in the treatment of subacute or chronic angle-closure glaucoma after iridectomy or where surgery is refused or contraindicated.
Echodide is also used to associated treatment for these conditions: Accommodative component in esotropia, Chronic Angle-closure Glaucoma, Open-angle Glaucoma (OAG), Nonuveitic secondary glaucoma
How Echodide works
Echodide Iodide is a long-acting cholinesterase inhibitor for topical use which enhances the effect of endogenously liberated acetylcholine in iris, ciliary muscle, and other parasympathetically innervated structures of the eye. Echodide iodide binds irreversibly to cholinesterase, and is long acting due to the slow rate of hydrolysis by cholinesterase. It causes miosis, increase in facility of outflow of aqueous humor, fall in intraocular pressure, and potentiation of accommodation.
Toxicity
Side effects include blurred vision or change in near or distant vision and eye pain. LD50: 174 mcg/kg in rats. (MSDS)
Food Interaction
No interactions found.Echodide Hypertension interaction
[Moderate] Topically applied cholinergic agents are systemically absorbed, with the potential for producing rare but clinically significant systemic effects, including urinary incontinence, tightness of the bladder, increased gastric contractility and acid secretion, bradycardia, severe hypotension, bronchospasm, seizures, and coma.
Increases in blood pressure may occur rarely due to a nicotinic effect on sympathetic ganglia.
Therapy with ophthalmic cholinergic agents, particularly the long-acting cholinesterase inhibitors (e.g., demecarium and echothiophate), should be administered cautiously in patients with corneal abrasion (which may increase drug penetration), bronchospastic diseases, spastic gastrointestinal disturbances, urinary tract obstruction, peptic ulcer, pronounced bradycardia and hypotension, vascular hypertension, acute cardiac failure, recent myocardial infarction, epilepsy, parkinsonism, and other conditions that may respond adversely to vagotonic effects.
The usual precautions should be followed to minimize the risk of systemic toxicity, including digital compression of the nasolacrimal ducts (1 to 2 minutes) following instillation to limit drainage into the nasal chamber, where extensive absorption may occur, and washing hands after use to prevent skin absorption.
Excessive cholinergic effects may be reversed with parenterally administered atropine.
Echodide Disease Interaction
Major: retinal detachment, uveitis, narrow-angle/pupillary block glaucomaModerate: cataracts, systemic vagotonic effects, Down's syndrome
Elimination Route
This ophthalmic medication may be systemically absorbed.
Innovators Monograph
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