Echodide

Echodide Uses, Dosage, Side Effects, Food Interaction and all others data.

A potent, long-acting irreversible cholinesterase inhibitor used as an ocular hypertensive in the treatment of glaucoma. Occasionally used for accomodative esotropia.

Echodide Iodide is a potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma. Echodide iodide will depress both plasma and erythrocyte cholinesterase levels in most patients after a few weeks of eyedrop therapy.

Trade Name Echodide
Availability Prescription only
Generic Echothiophate
Echothiophate Other Names Echothiophate, Ecothiopate, Ecothiopatum, Phospholine
Related Drugs acetazolamide, nadolol, pilocarpine ophthalmic, Diamox, Combigan, mitomycin ophthalmic
Type
Formula C9H23NO3PS
Weight Average: 256.323
Monoisotopic: 256.113625809
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Echodide
Echodide

Uses

Echodide is an acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma.

For use in the treatment of subacute or chronic angle-closure glaucoma after iridectomy or where surgery is refused or contraindicated.

Echodide is also used to associated treatment for these conditions: Accommodative component in esotropia, Chronic Angle-closure Glaucoma, Open-angle Glaucoma (OAG), Nonuveitic secondary glaucoma

How Echodide works

Echodide Iodide is a long-acting cholinesterase inhibitor for topical use which enhances the effect of endogenously liberated acetylcholine in iris, ciliary muscle, and other parasympathetically innervated structures of the eye. Echodide iodide binds irreversibly to cholinesterase, and is long acting due to the slow rate of hydrolysis by cholinesterase. It causes miosis, increase in facility of outflow of aqueous humor, fall in intraocular pressure, and potentiation of accommodation.

Toxicity

Side effects include blurred vision or change in near or distant vision and eye pain. LD50: 174 mcg/kg in rats. (MSDS)

Food Interaction

No interactions found.

Echodide Hypertension interaction

[Moderate] Topically applied cholinergic agents are systemically absorbed, with the potential for producing rare but clinically significant systemic effects, including urinary incontinence, tightness of the bladder, increased gastric contractility and acid secretion, bradycardia, severe hypotension, bronchospasm, seizures, and coma.

Increases in blood pressure may occur rarely due to a nicotinic effect on sympathetic ganglia.

Therapy with ophthalmic cholinergic agents, particularly the long-acting cholinesterase inhibitors (e.g., demecarium and echothiophate), should be administered cautiously in patients with corneal abrasion (which may increase drug penetration), bronchospastic diseases, spastic gastrointestinal disturbances, urinary tract obstruction, peptic ulcer, pronounced bradycardia and hypotension, vascular hypertension, acute cardiac failure, recent myocardial infarction, epilepsy, parkinsonism, and other conditions that may respond adversely to vagotonic effects.

The usual precautions should be followed to minimize the risk of systemic toxicity, including digital compression of the nasolacrimal ducts (1 to 2 minutes) following instillation to limit drainage into the nasal chamber, where extensive absorption may occur, and washing hands after use to prevent skin absorption.

Excessive cholinergic effects may be reversed with parenterally administered atropine.

Elimination Route

This ophthalmic medication may be systemically absorbed.

Innovators Monograph

You find simplified version here Echodide

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https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:4753
http://www.hmdb.ca/metabolites/HMDB0015190
http://www.genome.jp/dbget-bin/www_bget?drug:D02193
http://www.genome.jp/dbget-bin/www_bget?cpd:C06975
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=10548
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505944
https://www.chemspider.com/Chemical-Structure.10108.html
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=89778
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=4753
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1201341
https://zinc.docking.org/substances/ZINC000001530628
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000962
http://www.pharmgkb.org/drug/PA164743139
http://www.rxlist.com/cgi/generic2/phospholine.htm
https://www.drugs.com/cdi/echothiophate-eye-drops.html
https://en.wikipedia.org/wiki/Echothiophate
*** Taking medicines without doctor's advice can cause long-term problems.
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