Echothiophate Iodide

Echothiophate Iodide Uses, Dosage, Side Effects, Food Interaction and all others data.

A potent, long-acting irreversible cholinesterase inhibitor used as an ocular hypertensive in the treatment of glaucoma. Occasionally used for accomodative esotropia.

Echothiophate Iodide Iodide is a potent, long-acting cholinesterase inhibitor used as a miotic in the treatment of glaucoma. Echothiophate Iodide iodide will depress both plasma and erythrocyte cholinesterase levels in most patients after a few weeks of eyedrop therapy.

Trade Name Echothiophate Iodide
Availability Prescription only
Generic Echothiophate
Echothiophate Other Names Echothiophate, Ecothiopate, Ecothiopatum, Phospholine
Related Drugs acetazolamide, nadolol, pilocarpine ophthalmic, Diamox, Combigan, mitomycin ophthalmic
Weight 0.125%
Type Ophthalmic powder for reconstitution
Formula C9H23NO3PS
Weight Average: 256.323
Monoisotopic: 256.113625809
Groups Approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Echothiophate Iodide
Echothiophate Iodide

Uses

Echothiophate Iodide is an acetylcholinesterase inhibitor used in ophthalmic preparations to increase the drainage of intraocular fluid; most commonly used for the treatment of glaucoma.

For use in the treatment of subacute or chronic angle-closure glaucoma after iridectomy or where surgery is refused or contraindicated.

Echothiophate Iodide is also used to associated treatment for these conditions: Accommodative component in esotropia, Chronic Angle-closure Glaucoma, Open-angle Glaucoma (OAG), Nonuveitic secondary glaucoma

How Echothiophate Iodide works

Echothiophate Iodide Iodide is a long-acting cholinesterase inhibitor for topical use which enhances the effect of endogenously liberated acetylcholine in iris, ciliary muscle, and other parasympathetically innervated structures of the eye. Echothiophate Iodide iodide binds irreversibly to cholinesterase, and is long acting due to the slow rate of hydrolysis by cholinesterase. It causes miosis, increase in facility of outflow of aqueous humor, fall in intraocular pressure, and potentiation of accommodation.

Toxicity

Side effects include blurred vision or change in near or distant vision and eye pain. LD50: 174 mcg/kg in rats. (MSDS)

Food Interaction

No interactions found.

Echothiophate Iodide Hypertension interaction

[Moderate] Topically applied cholinergic agents are systemically absorbed, with the potential for producing rare but clinically significant systemic effects, including urinary incontinence, tightness of the bladder, increased gastric contractility and acid secretion, bradycardia, severe hypotension, bronchospasm, seizures, and coma.

Increases in blood pressure may occur rarely due to a nicotinic effect on sympathetic ganglia.

Therapy with ophthalmic cholinergic agents, particularly the long-acting cholinesterase inhibitors (e.g., demecarium and echothiophate), should be administered cautiously in patients with corneal abrasion (which may increase drug penetration), bronchospastic diseases, spastic gastrointestinal disturbances, urinary tract obstruction, peptic ulcer, pronounced bradycardia and hypotension, vascular hypertension, acute cardiac failure, recent myocardial infarction, epilepsy, parkinsonism, and other conditions that may respond adversely to vagotonic effects.

The usual precautions should be followed to minimize the risk of systemic toxicity, including digital compression of the nasolacrimal ducts (1 to 2 minutes) following instillation to limit drainage into the nasal chamber, where extensive absorption may occur, and washing hands after use to prevent skin absorption.

Excessive cholinergic effects may be reversed with parenterally administered atropine.

Elimination Route

This ophthalmic medication may be systemically absorbed.

Innovators Monograph

You find simplified version here Echothiophate Iodide

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https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:4753
http://www.hmdb.ca/metabolites/HMDB0015190
http://www.genome.jp/dbget-bin/www_bget?drug:D02193
http://www.genome.jp/dbget-bin/www_bget?cpd:C06975
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=10548
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https://www.chemspider.com/Chemical-Structure.10108.html
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=89778
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=4753
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1201341
https://zinc.docking.org/substances/ZINC000001530628
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000962
http://www.pharmgkb.org/drug/PA164743139
http://www.rxlist.com/cgi/generic2/phospholine.htm
https://www.drugs.com/cdi/echothiophate-eye-drops.html
https://en.wikipedia.org/wiki/Echothiophate
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