Elitek Uses, Dosage, Side Effects and more
Elitek is a recombinant urate-oxidase enzyme produced by a genetically modified Saccharomyces cerevisiae strain. The cDNA coding for rasburicase was cloned from a strain of Aspergillus flavus.
Drugs used to treat lympohoid leukemia, non-Hodgkin's lymphoma and acute myelogenous leukemia often lead to the accumulation of toxic plasma levels of purine metabolites (i.e. uric acid). The injection of rasburicase reduces levels of uric acid and mitigates the toxic effects of chemotherapy induced tumor lysis.
| Trade Name | Elitek |
| Availability | Prescription only |
| Generic | Rasburicase |
| Rasburicase Other Names | Rasburicasa, Rasburicase, Urate oxidase |
| Related Drugs | allopurinol, sodium bicarbonate, Zyloprim, Elitek, Aloprim |
| Weight | 1.5mg, 7.5mg, |
| Type | Intravenous powder for injection |
| Formula | C1521H2381N417O461S7 |
| Weight | 34109.5 Da |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States, |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Elitek is a recombinant form of urate-oxidase enzyme used to treat hyperuricemia following chemotherapy for leukemias and non-Hodgkin's lymphoma.
For treatment of hyperuricemia, reduces elevated plasma uric acid levels (from chemotherapy)
Elitek is also used to associated treatment for these conditions: Hyperuricemia
How Elitek works
Elitek catalyzes enzymatic oxidation of uric acid into an inactive and soluble metabolite (allantoin).
Food Interaction
No interactions found.Drug Interaction
Unknown: aripiprazole, papain/urea topical, charcoal, doxorubicin, oxymetazoline nasal, antihemophilic factor/von willebrand factor, darbepoetin alfa, azithromycin, sulfamethoxazole / trimethoprim, meperidine, fluorouracil topical, heparin, levocarnitine, phenazopyridine, vitamin a topical, bioflavonoids, sotalol, cyanocobalamin, cholecalciferol, ondansetron
Disease Interaction
Volume of Distribution
- 110 to 127 mL/kg [pediatric patients]
- 75.8 to 138 mL/kg [adult patients]
Half Life
18 hours
