Elspar

Elspar Uses, Dosage, Side Effects, Food Interaction and all others data.

Elspar is a synthetic, broad-spectrum antibacterial agent from the difluoroquinolone family. It has been reported to be more active in vitro than ciprofloxacin against some organisms, including staphylococci and Mycobacteria, and has a much longer plasma half-life (16 hours).

Elspar inhibits the supercoiling activity of DNA gyrase which is an enzyme essential for DNA replication thus promoting the breakage of DNA structures. It has activity against S. pneumoniae, S. aureus, H. influenzae, K. pneumoniae, M. catarrhalis and Mycobacterium spp.

Elspar is a synthetic fluoroquinolone broad-spectrum antimicrobial agent in the same class as ofloxacin and norfloxacin. Elspar has in vitro activity against a wide range of gram-negative and gram-positive microorganisms. Elspar exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. Quinolones differ in chemical structure and mode of action from (beta)-lactam antibiotics. Quinolones may, therefore, be active against bacteria resistant to (beta)-lactam antibiotics. Although cross-resistance has been observed between sparfloxacin and other fluoroquinolones, some microorganisms resistant to other fluoroquinolones may be susceptible to sparfloxacin. In vitro tests show that the combination of sparfloxacin and rifampin is antagonistic against Staphylococcus aureus.

Trade Name Elspar
Availability Discontinued
Generic Sparfloxacin
Sparfloxacin Other Names Sparfloxacin
Related Drugs amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin, rifampin
Weight 40mg,
Type Tablet, Injection, Powder, Lyophilized, For Solution
Formula C19H22F2N4O3
Weight Average: 392.3998
Monoisotopic: 392.165997
Protein binding

Low plasma protein binding in serum at about 45%.

Groups Approved, Investigational, Withdrawn
Therapeutic Class 4-Quinolone preparations
Manufacturer Zee Laboratories Ltd, Meezab International
Available Country India, Pakistan, United States
Last Updated: September 19, 2023 at 7:00 am
Elspar
Elspar

Uses

Elspar is used for the treatment of the following infections due to susceptible microorganisms:

  • Upper and lower respiratory tract infections including sinusitis, acute exacerbation of chronic bronchitis, community and hospital acquired pneumonia.
  • Urinary tract infections including gonococcal and non-gonococcal urethritis, chancroid and other sexually transmitted diseases.
  • Skin and soft tissue infections.
  • Prophylactic use in different urological and ophthalmic operations.

Elspar is also used to associated treatment for these conditions: Acute Sinusitis, Chronic Obstructive Airways Disease Exacerbated, Community Acquired Pneumonia (CAP), Susceptible infections

How Elspar works

The bactericidal action of sparfloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.

Dosage

Elspar dosage

In patients with normal renal function the recommended daily dose is two tablets of Elspar 200 mg on first day as a loading dose, thereafter take one tablet of Elspar 200 mg every 24 hours for a total of 10 days of therapy.

The recommended daily dose of Elspar in patients with renal impairment (Creatinine clearance < 30 ml/min) is two tablets of 200 mg taken on the first day as a loading dose. Thereafter, should be taken one tablet of 200 mg every 48 hours for total of 9 days of therapy.

Elspar can be taken with or without food.

Side Effects

Most of the adverse events were mild to moderate in severity and transient in nature. The most frequently reported events among the Elspar treated patients with the recommended dosage are: diarrhea, nausea, headache, dyspepsia, dizziness, insomnia, abdominal pain and QTc interval prolongation.

Toxicity

Single doses of sparfloxacin were relatively non-toxic via the oral route of administration in mice, rats, and dogs. No deaths occurred within a 14-day post-treatment observation period at the highest oral doses tested, up to 5000 mg/kg in either rodent species, or up to 600 mg/kg in the dog. Clinical signs observed included inactivity in mice and dogs, diarrhea in both rodent species, and vomiting, salivation, and tremors in dogs.

Precaution

It should be used with caution in renal diseases, gastric ulcers and with concomitant use of NSAIDs. In renal failure of third degree severity (creatinine clearance < 30 ml/min) dosage modification is recommended 400 mg on 1st day, 200 mg on 2nd and 3rd day followed by 200 mg every 48 hours. Because fluoroquinolones have been associated with tendon rupture, Elspar should be discontinued at the first sign of tendon pain. Exposure to UV radiation during treatment should be avoided.

Interaction

On concomitant use with Quinidine, Sotalol, Erythromycin, Astemizole, Terfenadine, vinca alkaloids there is increased risk of arrhythmia. Salts, oxides and hydroxides of Magnesium, Aluminium and Calcium decrease absorption of Elspar.

Elspar multivitamins interaction

[Moderate] ADJUST DOSING INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics.

Absorption may also be reduced by sucralfate, which contains aluminum, as well as other polyvalent cations such as iron and zinc.

The mechanism is chelation of quinolones by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract.

The bioavailability of ciprofloxacin has been reported to decrease by as much as 90% when administered with antacids containing aluminum or magnesium hydroxide.

When coadministration cannot be avoided, quinolone antibiotics should be dosed either 2 to 4 hours before or 4 to 6 hours after polyvalent cation-containing products to minimize the potential for interaction.

When coadministered with Suprep Bowel Prep (magnesium

Please consult individual product labeling for specific recommendations.

Elimination Route

Well absorbed following oral administration with an absolute oral bioavailability of 92%. Unaffected by administration with milk or food, however concurrent administration of antacids containing magnesium hydroxide and aluminum hydroxide reduces the oral bioavailability of sparfloxacin by as much as 50%.

Half Life

Mean terminal elimination half-life of 20 hours (range 16-30 hours). Prolonged in patients with renal impairment (creatinine clearance <50 mL/min).

Pregnancy & Breastfeeding use

There are no adequate and well controlled studies in pregnant women. Elspar should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Contraindication

Elspar is contraindicated for individuals with a history of hypersensifivity and in achilles tend in its following the use of fluoroquinolone and in pregnancy and lactation. Elspar is contraindicated in patients with known QTc prolongation or in patients being treated concomitantly with medications known to produce an increase in the QTc interval and/or torsade depointes.

Special Warning

Use in children: Safety and effectiveness have not been established in patients below the age of 18 years.

Storage Condition

Store at temperature below 30° C.

Innovators Monograph

You find simplified version here Elspar

Elspar contains Sparfloxacin see full prescribing information from innovator Elspar Monograph, Elspar MSDS, Elspar FDA label

FAQ

What is Elspar used for?

Elspar is an antibiotic in a class of drugs called fluoroquinolones. It fights bacteria in the body. Elspar is used to treat various types of bacterial infections.

How safe is Elspar?

Elspar passes into breast milk and may harm a nursing infant. It may affect bone development. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

What are the common side effects of Elspar?

The common side effects of  Elspar are include:

  • nausea
  • vomiting
  • diarrhea
  • constipation
  • headache
  • lightheadedness
  • drowsiness
  • ringing in the ears
  • increased sensitivity of the skin to sunlight
  • indigestion
  • dizziness
  • insomnia
  • abdominal pain
  • itching
  • changes in taste
  • gas
  • elevated blood pressure, and
  • heart rhythm disorders

Is Elspar safe during breastfeeding?

Elspar should be used during pregnancy only if the possible benefit outweighs the possible risk to the unborn baby. No studies have been done in animals, and no well-controlled studies have been done in pregnant women. Elspar should be given to a pregnant woman only if clearly needed.

Is Elspar safe during pregnancy?

Use of Elspar is acceptable in nursing mothers with monitoring of the infant for possible effects on the gastrointestinal flora, such as diarrhea or candidiasis.

How should I take Elspar?

Take Elspar exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.
Take each dose with a full glass of water (8 ounces). Drink several extra glasses of fluid each day to prevent the formation of Elspar crystals in your urine.

How do I take Elspar?

Take each dose with a full glass of water (8 ounces). Drink several extra glasses of fluid each day to prevent the formation of Elspar crystals in your urine.Elspar may be taken with or without food. Take Elspar at evenly spaced intervals.

How long does Elspar take to work?

You will start to feel better in 2 to 3 days after taking/using Elspar.

What happens if I miss a dose of Elspar?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.

What happens if I overdose?

Seek emergency medical attention.
The most common symptom of a Elspar overdose is irregular or slow heartbeats.

Can I drive after taking Elspar?

Do not drive a car or work on dangerous machines until you know how Elspar will affect you. plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen.

Can Elspar treat staphylococcus?

In vitro tests show that the combination of Elspar and rifampin is antagonistic against Staphylococcus aureus.

Is Elspar an antibiotic?

Elspar is an antibiotic in a class of drugs called fluoroquinolones. It fights bacteria in the body. Elspar is used to treat various types of bacterial infections.

*** Taking medicines without doctor's advice can cause long-term problems.
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