Emedastine

Emedastine Uses, Dosage, Side Effects, Food Interaction and all others data.

Emedastine is an antihistamine used in eye drops to treat allergic conjunctivitis.

Emedastine is a relatively selective H1-receptor antagonist.

Trade Name Emedastine
Generic Emedastine
Emedastine Other Names Emedastina, Emedastine, Emedastinum
Type Ophthalmic
Formula C17H26N4O
Weight Average: 302.4145
Monoisotopic: 302.210661474
Groups Approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Emedastine
Emedastine

Uses

Emedastine is a selective H1-receptor antagonist used topically to manage symptoms of allergic conjunctivitis.

For the temporary relief of the signs and symptoms of allergic conjunctivitis.

Emedastine is also used to associated treatment for these conditions: Seasonal Allergic Conjunctivitis

How Emedastine works

Emedastine is a relatively selective, histamine H1 antagonist. In vitro examinations of emedastine's affinity for histamine receptors demonstrate relative selectivity for the H1 histamine receptor. In vivo studies have shown concentration-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva following topical ocular administration. Emedastine appears exert negligible effects on adrenergic, dopaminergic and serotonin receptors.

Toxicity

Somnolence and malaise have been reported following daily oral administration.

Food Interaction

No interactions found.

Elimination Route

Ophthalmic use of emedastine usually does not produce measurable plasma concentrations.

Half Life

The elimination half-life in the plasma is 3-4 hours following oral administration.

Elimination Route

Following oral administration, approximately 44% of the total dose can be recovered in the urine over the 24-hour period, with only 3.6% of the dose excreted as unchanged form. Two primary metabolites, 5- and 6-hydroxyemedastine, are excreted in the urine as both free and conjugated forms.

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*** Taking medicines without doctor's advice can cause long-term problems.
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