Emobac Cream 10%+0.1%+0.1%+10%
Emobac Cream 10%+0.1%+0.1%+10% Uses, Dosage, Side Effects, Food Interaction and all others data.
Each gram of lotion contains- Liquid Paraffin BP 25 mg Benzalkonium Chloride USP 1 mg Chlorhexidine Hydrochloride BP 1 mg Isopropyl Myristate BP 25 mg Each gram of cream contains- Liquid Paraffin BP 100 mg Benzalkonium Chloride USP 1 mg Chlorhexidine Hydrochloride BP 1 mg Isopropyl Myristate BP 100 mg| Trade Name | Emobac Cream 10%+0.1%+0.1%+10% |
| Generic | Liquid Paraffin + Benzalkonium Chloride + Chlorhexidine + Isopropyl Myristate |
| Weight | 10%+0.1%+0.1%+10% |
| Type | Cream |
| Therapeutic Class | Miscellaneous topical agents |
| Manufacturer | Incepta Pharmaceuticals Ltd. |
| Available Country | Bangladesh |
| Last Updated: | October 19, 2023 at 6:27 am |
Uses
This is an antimicrobial emollient lotion for the management of dry and pruritic skin conditions, especially eczema and dermatitis. The lotion is suitable for direct application, and for use as a soap substitute.Emobac Cream 10%+0.1%+0.1%+10% is also used to associated treatment for these conditions: Catarrh of the throat, Chemotherapy Induced Mucositis, Chronic Wounds, Decubitus Ulcer, Dental Cavity, Dysphagia, Eczema infected, Foeter Ex Ore, Gingival Bleeding, Gingival disorders NEC, Gingivitis, Glossitis, Hoarseness, Infection, Infectious Periodontal Diseases, Injury Throat, Mild to Moderate Inflammatory Reaction of the Oral Cavity, Mild to Moderate Inflammatory Reaction of the Pharynx, Mouth injury, Mucositis, Neurodermatitis, Ocular Inflammation, Ocular Irritation, Oral Aphthous Ulcer, Oral Infection, Pain, Periodontitis, Pharyngitis, Plaque, Dental, Postoperative Wound Infection, Purulent Gingivitis, Radiation Mucositis, Red eye, Ringworm, Skin Infections, Skin Infections, Bacterial, Sore Throat, Stomatitis, Surgical Wound, Tissue Damage, Tonsillitis, Ulcer, Aphthous, Ulcers, Leg, Wound Infections, Dry, cracked skin, Gum disorder, Gum pain, Moderate Gingivitis, Oral lesions, Recurrent Oral fungal infection, Severe Gingivitis, Superficial Wounds, Throat disinfection, Tongue inflammation, Anesthesia of Mucous Membrane, Antimicrobial Therapy, Contact Lens Care, Disinfection, Disinfection of External Genitalia, Disinfection of the Urethra, Disinfection of the Vaginal Mucosa, Irrigation therapy, Lubrication of the Urethra, Oral Care, Oral Hygiene, Oropharyngeal antisepsis, Skin disinfection, Surgical Scrubbing, Topical Antisepsis, Urethral Anesthesia, Wound Cleansing, Wound Healing, Oral antisepsis, Oral disinfectionHead Lice Infestation
How Emobac Cream 10%+0.1%+0.1%+10% works
Chlorhexidine’s broad-spectrum antimicrobial effects are due to its ability to disrupt microbial cell membranes. The positively charged chlorhexidine molecule reacts with negatively charged phosphate groups on microbial cell surfaces - this reaction both destroys the integrity of the cell, allowing leakage of intracellular material, and allows chlorhexidine to enter the cell, causing precipitation of cytoplasmic components and ultimately cell death. The specific means of cell death is dependent on the concentration of chlorhexidine - lower concentrations are bacteriostatic and result in leakage of intracellular substances such as potassium and phosphorous, whereas higher concentrations are bactericidal and cause cytoplasmic precipitation.
As a pediculicide, isopropyl myristate is capable of physically coating the exoskeleton bodies of lice . This physical coating subsequently immobilizes the lice and works to dissolve the wax covering on the insect exoskeleton and blocks the insects' airways, leading to death by dehydration . Although this physical action of isopropyl myristate results in little lice resistance (given the lack of immunologic or chemical activity in this mechanism of action), the substance is also not ovicidal, which means any eggs that may have been laid by lice would not be affected . Moreover, isopropyl myristate is capable of eliciting its pediculicide action in a contact time of only 10 minutes per each necessary administration .
Dosage
Emobac Cream 10%+0.1%+0.1%+10% dosage
Adults, Children and the Elderly: For application to the skin: Apply the lotion to the affected areas as required. Massage into the skin, until absorbed. For use as a soap substitute: This lotion may also be used as a cleanser in the bath or shower, or for other toiletry purposes, instead of ordinary soap or shower gel. Use it only on the skin. For maximum benefit you should use this product on a regular basis and as often as required.Before using the 500 ml bottle, turn the top of the pump dispenser anti-clockwise to unlock it. After unlocking, you will need to press down the pump dispenser several times to prime the pump before any product is dispensed. The same instructions apply for all age groups. For use as a leave-on application- Apply lotion to the affected areas. Gently smooth into the skin. If necessary, allow time for any excess to soak in. Do not rub the skin vigorously. Reapply as often as required. If you are applying another treatment to the same areas of skin as this lotion, try to avoid mixing the two products. This can be achieved by applying the treatments alternately, leaving sufficient time to allow the previous application to soak in. For use as a soap substitute- Use this lotion to wash with instead of your ordinary soap or shower gel. It will not foam or lather like ordinary cosmetic products. After washing, bathing or showering, pat the skin dry with a soft towel (avoid rubbing as this can make dry skin conditions worse).Side Effects
Like all medicines, this lotion can cause side effects, although not everybody gets them. If you experience any of the following reactions stop using this lotion and get urgent medical help: swelling of the face, lips, tongue or throat; a sudden uncharacteristic red itchy skin rash (hives) away from the site of application; wheezing or breathing difficulty; feeling faint or dizzy; a strange metallic taste in the mouth; or collapse. You may be having a serious allergic reaction. This product has been specially designed for use on dry or problem skin areas anywhere on the body. Rarely, this lotion can cause skin reactions on treated areas (involving redness, irritation and/or itching). These very rare skin reactions may become more significant where associated with excessive use as a leave-on application in areas of folded skin such as the groin or in the nappy areaToxicity
The LD50 of subcutaneously administered chlorhexidine in mice is >5 g/kg.
Small children are likely to be more susceptible to chlorhexidine overdose - ingestion of 1-2 ounces by a small child may result in gastric distress, nausea, and intoxication. Treatment should consist of symptomatic and supportive measures. Seek medical attention if a child ingests >4 ounces of chlorhexidine solution or if symptoms of intoxication develop post-exposure.
Readily available information regarding the pharmacokinetics of isopropyl myristate is not available .
Precaution
As with any product, severe generalised allergic reactions are possible. Very rare reports of such reactions in susceptible individuals, leading to a drop in blood pressure and even to unconsciousness, have been associated with products containing chlorhexidine. You must not use this lotion if you have had problems with chlorhexidine-containing products in the past.Do not smoke or go near naked flames-risk of severe burns. Fabric (clothing, bedding, dressings etc) that has been in contact with this product burns more easily and is a serious fire hazard. Washing clothing and bedding may reduce product build-up but not totally remove it.Take care when using this product: For patients with very sensitive skin, it is generally a good idea to start any new treatment on a small test area first, in case any side effect occurs. This is especially important when treating the face or young children. Thereafter, treatments may be applied more generously, as required. Avoid getting it in the eyes, especially when using it on the face. When used as a soap substitute in the bath or shower the product can make the surface slippery, so be careful to avoid slipping over when getting into and out of your shower or bath (e.g. by using a shower or bath mat). Cetostearyl alcohol may cause local skin reactions (e.g. contact dermatitis). If you have previously experienced local skin reactions (e.g. contact dermatitis) to any of the ingredients, please talk to your doctor before using this product.Interaction
This product is not known to affect, or to be affected by, other medicines.Volume of Distribution
Readily available information regarding the pharmacokinetics of isopropyl myristate is not available .
Elimination Route
Topically, chlorhexidine is unlikely to undergo any degree of systemic absorption. Orally administered chlorhexidine, such as that found in oral rinses for dental purposes, is very poorly absorbed from the gastrointestinal tract - the Cmax in human subjects following an oral dose of 300mg was 0.206 µg/g and occurred approximately 30 minutes after ingestion (Tmax). Following the insertion of 4 PerioChips in 18 adult patients, no detectable plasma or urine chlorhexidine levels were observed.
Dermal absorption of isopropyl myristate is predicated to be 0.00020 mg/cm2/event, which is considered a very low absorption rate . In a study, topically applied isopropyl myristate was largely retained in the stratum corneum . It was not detected in the receptor fluid of flow-through diffusion cells in in-vitro skin permeation experiments using human epidermis (stratum corneum and viable epidermis) and dermis of varying thickness .
Half Life
Readily available information regarding the pharmacokinetics of isopropyl myristate is not available .
Clearance
Readily available information regarding the pharmacokinetics of isopropyl myristate is not available .
Elimination Route
Excretion of chlorhexidine gluconate occurs almost exclusively via the feces, with less than 1% of an ingested dose excreted in the urine.
Readily available information regarding the pharmacokinetics of isopropyl myristate is not available .
Pregnancy & Breastfeeding use
This product can be used during pregnancy and whilst breast-feeding. The ingredients have been in widespread use in this and similar preparations for many years, without reports of problems. However, safety trials have not been conducted.Contraindication
This Lotion if you are allergic (hypersensitive) to benzalkonium chloride, chlorhexidine dihydrochloride, liquid paraffin, isopropyl myristate, or any of the other ingredients of this lotion.Storage Condition
Store in a cool and dry place, protect from light, do not store above 25°C. Keep out of children's reach. For external use only.Innovators Monograph
You find simplified version here Emobac Cream 10%+0.1%+0.1%+10%
