empliciti
empliciti Uses, Dosage, Side Effects, Food Interaction and all others data.
empliciti is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. empliciti targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family member 7, a cell surface glycoprotein. empliciti consists of the complementary determining regions (CDR) of the mouse antibody, MuLuc63, grafted onto human IgG1 heavy and kappa light chain frameworks. empliciti is produced in NS0 cells by recombinant DNA technology. empliciti has a theoretical mass of 148.1 kDa for the intact antibody. empliciti was approved on November 30, 2015 by the U.S. Food and Drug Administration. empliciti is marketed under the brand Empliciti™ by Bristol-Myers Squibb.
| Trade Name | empliciti |
| Availability | Prescription only |
| Generic | Elotuzumab |
| Elotuzumab Other Names | Elotuzumab, HuLuc63, Immunoglobulin G1, anti-(human protein CS1) (human-mouse HuLuc63 heavy chain), disulfide with human-mouse HuLuc63 kappa-chain, dimer |
| Related Drugs | Revlimid, Velcade, Darzalex, Pomalyst, Ninlaro, Kyprolis |
| Weight | 300mg, 400mg, |
| Type | Solution, Infusion, Intravenous Powder For Injection |
| Formula | C6476H9982N1714O2016S42 |
| Weight | 148100.0 Da |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | Bristol-myers Squibb, Bristol-myers Squibb Pharmaceuticals Limited |
| Available Country | Saudi Arabia, Australia, United Kingdom, United States, |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
empliciti is an antineoplastic agent and SLAMF7-directed immunostimulatory antibody used for the treatment of refractory multiple myeloma in combination with other antineoplastic agents.
Indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies.
empliciti is also used to associated treatment for these conditions: Refractory Multiple Myeloma
How empliciti works
empliciti is a humanized IgG1 monoclonal antibody that specifically targets the SLAMF7 (Signaling Lymphocytic Activation Molecule Family member 7) protein. SLAMF7 is expressed on myeloma cells independent of cytogenetic abnormalities. SLAMF7 is also expressed on Natural Killer cells, plasma cells, and at lower levels on specific immune cell subsets of differentiated cells within the hematopoietic lineage. empliciti directly activates Natural Killer cells through both the SLAMF7 pathway and Fc receptors. empliciti also targets SLAMF7 on myeloma cells and facilitates the interaction with Natural Killer cells to mediate the killing of myeloma cells through antibody-dependent cellular cytotoxicity (ADCC). In preclinical models, the combination of elotuzumab and lenalidomide resulted in enhanced activation of Natural Killer cells that was greater than the effects of either agent alone and increased anti-tumor activity in vitro and in vivo.
Food Interaction
No interactions found.empliciti Hypertension interaction
[Major] The use of monoclonal antibodies administered via IV infusion may cause serious infusion reactions, including bronchospasm, hypoxia, dyspnea, fluctuations in blood pressure, laryngeal edema and pulmonary edema.
Caution should be taken in patients with a history of cardiopulmonary disease as they may require additional post-infusion medications to manage respiratory complications.
It is recommended to administer required intravenous hydration and premedication with antihistamines, analgesics, and antipyretics before administration.
Monitor closely for signs and symptoms of infusion reactions during and for at least 4 hours following completion of each infusion in a setting where cardiopulmonary resuscitation medication and equipment are available.
Immediately interrupt or permanently discontinue treatment and institute supportive management for severe or prolonged infusion reactions as appropriate.
empliciti Drug Interaction
Moderate: lactobacillus acidophilus, pomalidomideUnknown: naproxen, alpha-lipoic acid, aspirin, hydroxyzine, amoxicillin / clavulanate, azithromycin, alpha-d-galactosidase, calcium / vitamin d, calcium / vitamin d, multivitamin with minerals, loratadine, ethanol, loperamide, lenalidomide, tramadol, cyanocobalamin, pyridoxine, zoledronic acid
empliciti Disease Interaction
Major: infections, infusion reactions, tumor lysis syndromeModerate: liver dysfunction
Clearance
The clearance of elotuzumab decreased from a geometric mean (CV%) of 17.5 (21.2%) to 5.8 (31%) mL/day/kg with an increase in dose from 0.5 (i.e., 0.05 times the recommended dosage) to 20 mg/kg (i.e., 2 times the recommended dosage). Based on a population PK model, when elotuzumab is given in combination with lenalidomide and dexamethasone, approximately 97% of the maximum steady-state concentration is predicted to be eliminated with a geometric mean (CV%) of 82.4 (48%) days.
Innovators Monograph
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