Emutin Child

Emutin Child Uses, Dosage, Side Effects, Food Interaction and all others data.

Emutin Child reduces goblet cell hyperplasia and therefore plays a role in the management of disorders characterised by abnormal mucous. Emutin Child loosens thick sputum effectively by reducing its viscosity and thereby helps to expectorate that mucus more easily from the respiratory tract. The mucolytic action happens in several mechanisms. It breaks the disulphide bonds, which cross-link certain glycoprotein molecules in the mucus, the mucus produced under the influence of Emutin Child has high sialomucin and low fucomucin content. This combined effect ultimately reduces the viscosity of the sputum and increases its volume.

Due to its mucolytic effects, carbocisteine significantly reduces sputum viscosity, cough, dyspnea and fatigue. Additionally, it prevents pulmonary infections by decreasing accumulated mucus in the respiratory tract; this is especially beneficial in preventing exacerbations of COPD caused by bacteria and viruses. It has in-vitro anti-inflammatory activity with some demonstrated action against free radicals.

Trade Name Emutin Child
Generic Carbocisteine
Carbocisteine Other Names carbocisteína, Carbocisteine, L-carbocysteine, S-carboxymethylcysteine
Weight 125mg/5ml
Type Syrup
Formula C5H9NO4S
Weight Average: 179.194
Monoisotopic: 179.025228471
Protein binding

Plasma protein binding information for carbocisteine is not readily available in the literature.

Groups Approved, Investigational
Therapeutic Class Cough expectorants & mucolytics
Manufacturer Enicar Pharmaceuticals Pvt Ltd
Available Country India, Nigeria
Last Updated: September 19, 2023 at 7:00 am
Emutin Child
Emutin Child

Uses

Emutin Child is used for- Acute bronchitis, Chronic bronchitis, Bronchial asthma, Upper respiratory tract inflammation (pharyngitis, laryngitis), Cystic fibrosis Bronchiectasis, Pulmonary tuberculosis, Drainage in chronic sinusitis and pneumonia, Drainage in otitis media in children.

Emutin Child is also used to associated treatment for these conditions: Cough, Respiratory Illness, Excess mucus or phlegm, Airway secretion clearance therapy

How Emutin Child works

The hypersecretion of mucus characterizes serious respiratory conditions including asthma, cystic fibrosis (CF), and chronic obstructive pulmonary disease (COPD). It blocks bacterial adherence to cells, preventing pulmonary infections. Glycoproteins (fucomucins, sialomucins and sulfomucins) regulate the viscoelastic properties of bronchial mucus. Increased fucomucins can be found in the mucus of patients with COPD. Emutin Child serves to restore equilibrium between sialomucins and fucomucins, likely by intracellular stimulation of sialyl transferase enzyme, thus reducing mucus viscosity.

A study found that L-carbocisteine can inhibit damage to cells by hydrogen peroxide (H2O2) by activating protein kinase B (Akt) phosphorylation, suggesting that carbocisteine may have antioxidant effects and prevent apoptosis of lung cells. There is some evidence that carbocisteine suppresses NF-κB and ERK1/2 MAPK signalling pathways, reducing TNF-alpha induced inflammation in the lungs, as well as other inflammatory pathways. An in-vitro study found that L-carbocisteine reduces intracellular adhesion molecule 1 (ICAM-1), inhibiting rhinovirus 14 infection, thereby reducing airway inflammation.

Dosage

Emutin Child dosage

Adult: Initially, 2.25 g daily in divided doses, then 1.5 g daily in divided doses as condition improves.

Child: 2-5 year: 62.5-125 mg 4 times daily; 6-12 year 250 mg tid.

Should be taken with food.

Side Effects

Gastrointestinal discomfort, nausea, diarrhoea, gastrointestinal bleeding, palpitation, dizziness, headache, heartburn and skin rash may occur.

Toxicity

The oral LD50 of carbocisteine in rats is >15000 mg/kg. An overdose with carbocisteine is likely to result in gastrointestinal discomfort with nausea and vomiting.

Precaution

No specific precaution is recommended but Emutin Child should be used with caution in patients with a recent history of peptic ulcer and recurrent gastrointestinal bleeding.

Interaction

Neither hazardous nor therapeutically useful interactions have been reported.

Food Interaction

  • Take with or without food.

Volume of Distribution

Emutin Child penetrates well into the lung and bronchial secretions.

Elimination Route

Emutin Child is rapidly absorbed in the gastrointestinal tract when taken orally with peak serum concentrations achieved within 1 to 1.7 hours.

Half Life

The plasma half-life of carbicostine is 1.33 hours.

Clearance

Clearance information for carbocisteine is not readily available in the literature.

Elimination Route

About 30% to 60% of an orally administered dose is detected unchanged in the urine.

Pregnancy & Breastfeeding use

There is no information on the use of Emutin Child during lactation. While there are no reports of teratogenic effects, the manufacturers do not recommend the use of Emutin Child in the first trimester.

Contraindication

Contraindicated in active peptic ulceration and in patients with hypersensitivity to the drug.

Acute Overdose

Symptoms: GI disturbance.

Management: May perform gastric lavage, followed by observation.

Storage Condition

Store in a cool and dry place protected from light.

Innovators Monograph

You find simplified version here Emutin Child

Emutin Child contains Carbocisteine see full prescribing information from innovator Emutin Child Monograph, Emutin Child MSDS, Emutin Child FDA label

*** Taking medicines without doctor's advice can cause long-term problems.
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