Endogel (Sodium Hyaluronate)
Endogel (Sodium Hyaluronate) Uses, Dosage, Side Effects, Food Interaction and all others data.
Sodium hyaluronate is a polysaccharide which functions as a tissue lubricant. It is widely used in ophthalmic surgery because it forms a viscoelastic solution in water which makes it a suitable substitute for aqueous and vitreous humour.
| Trade Name | Endogel (Sodium Hyaluronate) |
| Generic | Sodium Hyaluronate |
| Type | |
| Therapeutic Class | Drugs for Osteoarthritis |
| Manufacturer | |
| Available Country | Germany |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Endogel (Sodium Hyaluronate) is used for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy, and to simple analgesics, e.g., acetaminophen.
Endogel (Sodium Hyaluronate) is a viscous solution consisting of a high molecular weight fraction of purified natural sodium hyaluronate in buffered physiological sodium phosphate. It has a pH of 5.5-7.0. Hyaluronic acid is an important component of the body's extracellular matrix and is present in a particularly high concentration in cartilage and synovial fluid. Endogenous hyaluronic acid provides viscosity and elasticity to synovial fluid, which is fundamental for its lubricating and shock absorbing properties. It is essential for the correct structure of proteoglycans in articular cartilage. In osteoarthritis there is an insufficient amount of and a chance in the quality of hyaluronic acid in synovial fluid and cartilage. The intra-articular administration of hyaluronic acid into arthritic joints with degenerating cartilage surfaces and pathologically altered synovial fluid improved functions.
Dosage
Endogel (Sodium Hyaluronate) dosage
Endogel (Sodium Hyaluronate) is administered by intra-articular injection. A treatment cycle consists of five injections given at weekly intervals. Some patients may experience benefit with three injections given at weekly intervals. Inject the full 2 ml in one knee only. If treatment is bilateral, a separate injection should be used for each knee.
Side Effects
The common side-effects include gastrointestinal complaints, injection site pain, knee swelling/effusion, local skin reactions (rash, ecchymosis), pruritus, and headache.
Precaution
Use caution when injecting Endogel (Sodium Hyaluronate) into patients who are allergic to avian proteins, feathers, and egg products. Strict aseptic administration technique must be followed. Remove joint effusion, if present, before injecting Endogel (Sodium Hyaluronate). Do not use the same syringe for removing joint effusion and for injecting Endogel (Sodium Hyaluronate). It is recommended that the patient avoid any strenuous activities or prolonged (i.e., more than 1 hour) weight-bearing activities such as jogging or tennis within 48 hours following the intra-articular injection.
Pregnancy & Breastfeeding use
The safety and effectiveness of Endogel (Sodium Hyaluronate) have not been established in pregnant women. It is not known if Endogel (Sodium Hyaluronate) is excreted in human milk. The safety and effectiveness of Endogel (Sodium Hyaluronate) have not been established in lactating mother. The safety and effectiveness of Endogel (Sodium Hyaluronate) have not been demonstrated in children.
Contraindication
The drug is contraindicated in patients with known hypersensitivity to hyaluronate preparations. Intra-articular injections are contraindicated in cases of past and present infections or skin diseases in the area of the injection site.
Acute Overdose
No case of over dosage has been reported to date.
Storage Condition
Hyronate injection should be stored in a cool (below 25° C) and dry place and protected from light. Protect from freezing.
Innovators Monograph
You find simplified version here Endogel (Sodium Hyaluronate)
FAQ
What is Endogel (Sodium Hyaluronate) used for?
Endogel (Sodium Hyaluronate) topical skin medication is used to treat skin ulcers such as bed sores or diabetic foot ulcers, as well as burn wounds, surgical incisions, cuts, abrasions, and other skin irritations. Endogel (Sodium Hyaluronate) skin medication is also used to treat dry or scaly skin.
How safe is Endogel (Sodium Hyaluronate)?
Endogel (Sodium Hyaluronate) as well as are considered safe. It's rarely associated with side effects when applied topically.
How does Endogel (Sodium Hyaluronate) work?
Endogel (Sodium Hyaluronate) works by pulling in moisture from the environment and the underlying layers of your skin into the epidermis.
What are the common side effects of Endogel (Sodium Hyaluronate)?
The common side effects of Endogel (Sodium Hyaluronate) are include:
- warmth, pain, redness, stiffness, bruising, or puffiness where the medicine was injected;
- nausea, stomach pain;
- trouble walking;
- swelling in your hands or feet;
- back pain, joint pain, muscle pain;
- numbness or tingly feeling;
- headache, dizziness; or
- runny or stuffy nose, sneezing, sore throat.
How is Endogel (Sodium Hyaluronate) given?
Endogel (Sodium Hyaluronate) is injected directly into your knee joint. A healthcare provider will give you this injection.
Endogel (Sodium Hyaluronate) is usually given once every week for 3 to 5 weeks. Follow your doctor's dosing instructions very carefully.
Who should not take Endogel (Sodium Hyaluronate)?
You should not receive a Endogel (Sodium Hyaluronate) injection if you have an infection in your knee or in the skin around your knee.
Is Endogel (Sodium Hyaluronate) safe during pregnancy?
Endogel (Sodium Hyaluronate) also safe to use during pregnant.
Is Endogel (Sodium Hyaluronate) safe during breastfeeding?
It is not known whether Endogel (Sodium Hyaluronate) topical passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Is Endogel (Sodium Hyaluronate) safe for skin?
Endogel (Sodium Hyaluronate) are considered safe. It's rarely associated with side effects when applied topically.
How long take Endogel (Sodium Hyaluronate)?
Endogel (Sodium Hyaluronate) usually given once every week for 3 to 5 weeks.
How long does Endogel (Sodium Hyaluronate) last?
Endogel (Sodium Hyaluronate) lasts for about six months or longer in most people.
How much Endogel (Sodium Hyaluronate) should I take?
Doses of 120–240 mg per day for at least one month have been shown to significantly increase skin moisture and reduce dry skin in adults.
Does Endogel (Sodium Hyaluronate) have long term benefits?
Studies show that long term use is safe, with no reported side effects from Endogel (Sodium Hyaluronate) supplementation. Used as a topical skincare ingredient, Endogel (Sodium Hyaluronate) is also well tolerated.
Is it OK to use Endogel (Sodium Hyaluronate) every day?
Yes, you can even use it twice a day as long as you're applying it to clean, damp skin, then locking it in with a moisturizer and face oil.
What happens if you use too much Endogel (Sodium Hyaluronate)?
Too much Endogel (Sodium Hyaluronate) can leave skin thirstier, and dehydration lines more prominent.
Does Endogel (Sodium Hyaluronate) lighten dark spots?
Endogel (Sodium Hyaluronate) can also minimize age spots and prevent any dark spots in the future on your skin.
Can Endogel (Sodium Hyaluronate) dry skin?
Endogel (Sodium Hyaluronate) is one of the most hydrating ingredients, but if misused,Endogel (Sodium Hyaluronate) can actually dry out your skin.
Is Endogel (Sodium Hyaluronate) good for pimples?
While Endogel (Sodium Hyaluronate) can't fill in visible acne scars, it can help reduce redness and the visible appearance of acne.
Is Endogel (Sodium Hyaluronate) good for wrinkles?
Endogel (Sodium Hyaluronate) is well known for its skin benefits, especially alleviating dry skin, reducing the appearance of fine lines and wrinkles and speeding up wound healing.
Is Endogel (Sodium Hyaluronate) good for hair?
You can use Endogel (Sodium Hyaluronate) regardless of your hair type. It'll help your hair follicles lock in moisture.
Can I use Endogel (Sodium Hyaluronate) under eyes?
Yes you can.Endogel (Sodium Hyaluronate) can help mask darkness under the eyes.
What does Endogel (Sodium Hyaluronate) do to your face?
Endogel (Sodium Hyaluronate) helps reduce the visibility of fine lines and wrinkles retaining moisture to the skin.
Can Endogel (Sodium Hyaluronate) cause facial hair growth?
Endogel (Sodium Hyaluronate) is similar to a fertilizer because it can increase hair growth.
What happen If I missed Endogel (Sodium Hyaluronate)?
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.
What happens if I overdose?
Endogel (Sodium Hyaluronate) may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing.call a poison control center right away.
