Engmox
Engmox Uses, Dosage, Side Effects, Food Interaction and all others data.
Engmox is a synthetic broad spectrum, flouroquinolone derivative antibacterial agent. Engmox has in vitro activity against a wide range of Gram-positive and Gram-negative microorganisms. The bactericidal action of Engmox results from inhibition of the topoisomerase II (DNA gyrase) and topoisomerase IV required for bacterial DNA replication, transcription, repair and recombination.
Engmox is a quinolone/fluoroquinolone antibiotic. Engmox can be used to treat infections caused by the following bacteria: Aerobic Gram-positive microorganisms: Corynebacterium species, Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus warneri, Streptococcus pneumoniae, and Streptococcus viridans group. Aerobic Gram-negative microorganisms: Acinetobacter lwoffii, Haemophilus influenzae, and Haemophilus parainfluenzae. Other microorganisms: Chlamydia trachomatis.Engmox is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Engmox is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
| Trade Name | Engmox |
| Availability | Prescription only |
| Generic | Moxifloxacin |
| Moxifloxacin Other Names | Moxifloxacin, Moxifloxacino |
| Related Drugs | amoxicillin, prednisone, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin |
| Weight | 400mg |
| Type | Tablet |
| Formula | C21H24FN3O4 |
| Weight | Average: 401.4314 Monoisotopic: 401.175084476 |
| Protein binding | 50% bound to serum proteins, independent of drug concentration. |
| Groups | Approved, Investigational |
| Therapeutic Class | 4-Quinolone preparations |
| Manufacturer | English Pharmaceuticals Industries |
| Available Country | Pakistan |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Engmox is used for the treatment of adults (>18 years of age) with infections caused by susceptible strains of the designated microorganisms in the conditions listed below-
- Acute Bacterial Sinusitis caused by Streptococcus pneumoniae, Haemophilus infuenzae or Moraxella catarrhalis.
- Acute Bacterial Exacerbation of Chronic Bronchitis caused by Streptococcus pneumoniae, Haemophilus infuenzae, Haemophilus parainfuenzae, Klebsiella pneumoniae, methicillin-susceptible Staphylococcus aureus or Moraxella catarrhalis
- Community Acquired Pneumonia caused by Streptococcus pneumoniae (including multi-drug resistant strains), Haemophilus infuenzae, Moraxella catarrhalis, methicillin-susceptible Staphylococcus aureus, Klebsiella pneumoniae, Mycoplasma pneumoniae or Chlamydophilia pneumoniae.
- Uncomplicated Skin and Skin Structure Infections caused by methicillin-susceptible Staphylococcus aureus or Streptococcus pyogen.
- Complicated Skin and Skin Structure Infections caused by methicillin-susceptible Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae or Enterobacter cloacae.
- Complicated Intra-Abdominal Infections including polymicrobial infections such as abscess caused by Escherichia coli, Bacteroides fragilis, Streptococcus anginosus, Streptococcus constellatus, Enterococcus faecalis, Proteus mirabilis, Clostridium perfringens, Bacteroides thetaiotaomicron or Peptostreptococcus species.
Engmox is also used to associated treatment for these conditions: Acute Exacerbation of Chronic Bronchitis (AECB), Bacterial Conjunctivitis, Community Acquired Pneumonia (CAP), Plague, Postoperative Inflammatory Response, Sinusitis, Skin Infections, Ocular bacterial infections, Post-operative infection
How Engmox works
The bactericidal action of moxifloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during bacterial cell division.
Dosage
Engmox dosage
The dose of Engmox is 400 mg once every 24 hours. The duration of therapy depends on the type of infection as described bellow-
- In Acute Bacterial Sinusitis: Engmox 400 mg is given once daily for 10 days.
- In Acute Bacterial Exacerbation of Chronic Bronchitis: Engmox 400 mg is given once daily for 5 days.
- In Community Acquired Pneumonia: Engmox 400 mg is given once daily for 7-14 days.
- In Uncomplicated Skin & Skin Structure infections: Engmox 400 mg is given once daily for 7 days.
- In Complicated Skin & Skin Structure infections: Engmox 400 mg is given once daily for 7-21 days.
- In Complicated Intra-Abdominal infections: Engmox 400 mg is given once daily for 5-14 days.
Engmox 400 mg IV infusion can be administered intravenously for the entire treatment duration. Alternatively, therapy may be initial intravenous administration, followed by oral administration when clinically indicated. The recommended duration of treatment for the indication being treated should not be exceeded. The solution for infusion should be infused intravenously over 60 minutes.
Side Effects
The following one or more side effects may be observed: tendinopathy and tendon rupture, QT prolongation, hypersensitivity reactions, Clostridium difficile-associated diarrhea, peripheral neuropathy, photosensitivity, phototoxicity etc.
Toxicity
Symptoms of overdose include CNS and gastrointestinal effects such as decreased activity, somnolence, tremor, convulsions, vomiting, and diarrhea. The minimal lethal intravenous dose in mice and rats is 100 mg/kg.
Precaution
Engmox should be discontinued at the first appearance of a skin rash or any other sign of hypersensitivity. Engmox should be discontinued if the patient experiences pain, swelling, inflammation or rupture of a tendon.
Interaction
No quinolone should be co-administered with any solution containing multivalent cations (e.g. magnesium) through the same intravenous line. Antacids, iron and adsorbents reduce absorption of Engmox. NSAID may increase the risk of CNS stimulation. Warfarin may increase the risk of bleeding.
Food Interaction
- Drink plenty of fluids.
- Take with or without food.
Engmox multivitamins interaction
[Moderate] ADJUST DOSING INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics.
Absorption may also be reduced by sucralfate, which contains aluminum, as well as other polyvalent cations such as iron and zinc.
The mechanism is chelation of quinolones by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract.
The bioavailability of ciprofloxacin has been reported to decrease by as much as 90% when administered with antacids containing aluminum or magnesium hydroxide.
When coadministration cannot be avoided, quinolone antibiotics should be dosed either 2 to 4 hours before or 4 to 6 hours after polyvalent cation-containing products to minimize the potential for interaction.
When coadministered with Suprep Bowel Prep (magnesium Please consult individual product labeling for specific recommendations.
Engmox Drug Interaction
Moderate: aspirin, aspirin, aspirin, celecoxib, albuterol / ipratropium, budesonide / formoterolUnknown: amoxicillin / clavulanate, diphenhydramine, ubiquinone, duloxetine, omega-3 polyunsaturated fatty acids, furosemide, atorvastatin, metoprolol, acetaminophen, acetaminophen, cyanocobalamin, pyridoxine, ascorbic acid, cholecalciferol
Engmox Disease Interaction
Major: colitis, liver disease, CNS disorders, myasthenia gravis, peripheral neuropathy, QT interval prolongation, tendonitisModerate: crystalluria, diabetes
Volume of Distribution
- 1.7 to 2.7 L/kg
Elimination Route
Well absorbed from the gastrointestinal tract. Absolute oral bioavailability is approximately 90%. Food has little effect on absorption.
Half Life
11.5-15.6 hours (single dose, oral)
Clearance
- 12 +/- 2 L/hr
Elimination Route
Approximately 45% of an oral or intravenous dose of moxifloxacin is excreted as unchanged drug (~20% in urine and ~25% in feces).
Pregnancy & Breastfeeding use
Pregnancy Category C. Engmox is not recommended during pregnancy & lactation.
Contraindication
Engmox is contraindicated in persons with a history of hypersensitivity to Engmox or any member of the quinolone class of antimicrobial agents and any component of this formulation.
Special Warning
Elderly: No adjustment of dosage is required in the elderly.
Children: Efficacy and safety of Engmox IV infusion in children and adolescent have not been established.
Acute Overdose
In the events of an acute overdose, the stomach should be emptied. The patient should be kept under observation and appropriate hydration should be maintained.
Storage Condition
Store between 15 to 30° C. Protect from light and moisture. Keep away from reach of children.
Innovators Monograph
You find simplified version here Engmox
Engmox contains Moxifloxacin see full prescribing information from innovator Engmox Monograph, Engmox MSDS, Engmox FDA label
FAQ
What is Engmox used for?
Engmox is used to treat certain infections caused by bacteria such as pneumonia, and skin, and abdominal (stomach area) infections.Engmox is also used to prevent and treat plague a serious infection that may be spread on purpose as part of a bioterror attack.
How safe is Engmox?
Engmox may cause problems with bones, joints, and tissues around joints in children.Engmox should not be given to children younger than 18 years old.Engmox may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
How does Engmox work?
Engmox works by killing the bacteria that cause infections. Antibiotics such as Engmox will not work for colds, flu, or other viral infections.
What are the common side effects of Engmox?
The common side effects of Engmox are include:
- nausea.
- vomiting.
- stomach pain.
- diarrhea.
- constipation.
- heartburn
Is Engmox safe during pregnancy?
Use is considered acceptable; according to some experts,this drug should be used during pregnancy only if the benefit outweighs the risk to the fetus.
Is Engmox safe during breastfeeding?
Use of Engmox is acceptable in nursing mothers with monitoring of the infant for possible effects on the gastrointestinal flora, such as diarrhea or candidiasis..Engmox is preferable to use an alternate drug for which safety information is available.
Can I drink alcohol with Engmox?
Do not drink alcohol. Drinking alcohol can increase the chance of liver problems while you are taking Engmox. Avoid hard physical activity. Although not common, Engmox can make it easier to get tendon injuries.
Can I drive after taking Engmox?
Do not drive or do anything else that could be dangerous until you know how this medicine affects you.
What is the best time to take Engmox?
Engmox is usually taken with or without food once a day for 5 to 21 days. The length of treatment depends on the type of infection being treated. Your doctor will tell you how long to take Engmox. Take Engmox at around the same time every day.
Can I take Engmox at night?
Take Engmox exactly as your doctor tells you to. You will be prescribed a dose of one tablet a day. Try to take the tablets at the same time of day each day, as this will help you to remember to take Engmox regularly.
Is Engmox a good antibiotic?
Normally, Engmoxis not a dangerous antibiotic for most people, but in rare cases, it can cause serious side effects such as heart rhythm problems, liver damage, and tendon rupture.
Does Engmox make me sleepy?
Engmox may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally.
Can Engmox cause blurry vision?
Engmox ophthalmic may cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.
Can Engmox increase heart rate?
Engmox causes increase heart rate greater than 10 bpm.
How often can I use Engmox?
Engmox is usually used three times a day for 7 days. Try to use at around the same times every day.
Can I overdose on Engmox?
An overdose of Engmox ophthalmic is not expected to be dangerous. Seek emergency medical attention if anyone has accidentally swallowed the medication. Do not use other eye medications unless your doctor tells you to.
Can Engmox cause permanent damage?
Engmox can cause long-lasting, disabling and potentially permanent side effects involving tendons, muscles, joints and the nervous system.
How long does btrand stay in my body?
The elimination half-life of Engmox is 11.5 to 15.6 hours .About 45% of an oral or intravenous dose of Engmox is excreted as unchanged drug.
Can I take Engmox for a long time?
Engmox oral tablet is used for short-term treatment.
How long can I take Engmox?
Engmox comes as tablet to take by mouth.Engmox is usually taken with or without food once a day for 5 to 21 days. The length of treatment depends on the type of infection being treated.
Who should Engmox take Engmox?
Stop using Engmox and call your doctor at once if you have symptoms such as:headache, hunger, irritability, numbness, tingling, burning pain, confusion, agitation, paranoia, problems with memory or concentration, thoughts of suicide, or sudden pain or movement problems in any of your joints.
