Enkaid

Enkaid Uses, Dosage, Side Effects, Food Interaction and all others data.

All drug products containing encainide hydrochloride. Enkaid hydrochloride, formerly marketed as Enkaid capsules, was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack. The manufacturer of Enkaid capsules voluntarily withdrew the product from the US market on December 16, 1991.

Used to treat irregular heartbeats, encainide decreases excitability, conduction velocity, and automaticity as a result of slowed atrial, atrioventricular (AV) nodal, His-Purkinje, and intraventricular conduction. It causes a slight but significant prolongation of refractory periods in these tissues. The greatest effect is on the His-Purkinje system. Enkaid decreases the rate of rise of the action potential without markedly affecting its duration.

Trade Name Enkaid
Generic Encainide
Encainide Other Names Encainida, Encainide, Encainidum
Type Capsules
Formula C22H28N2O2
Weight Average: 352.4699
Monoisotopic: 352.21507815
Groups Approved, Investigational, Withdrawn
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Enkaid
Enkaid

Uses

Enkaid is a voltage-gated sodium channel blocker used for management of atrial or ventricular fibrillation, atrial flutter, and ventricular tachycardia, that is no longer used due to proarrhythmic adverse effects.

Enkaid is a class Ic antiarrhythmic agent which was used for management of irregular heartbeats, such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation.

How Enkaid works

Enkaid is a sodium channel blocker, binding to voltage gated sodium channels. It stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses. Ventricular excitability is depressed and the stimulation threshold of the ventricle is increased during diastole.

Half Life

1-2 hours

Elimination Route

A radiolabeled dose of encainide is excreted in approximately equal amounts in the urine and feces.

Innovators Monograph

You find simplified version here Enkaid

*** Taking medicines without doctor's advice can cause long-term problems.
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