Enoxacin - Bai Ke Heng Di Pharm
Enoxacin - Bai Ke Heng Di Pharm Uses, Dosage, Side Effects, Food Interaction and all others data.
A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.
Enoxacin - Bai Ke Heng Di Pharm is a quinolone/fluoroquinolone antibiotic. Enoxacin - Bai Ke Heng Di Pharm is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Enoxacin - Bai Ke Heng Di Pharm is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. Enoxacin - Bai Ke Heng Di Pharm may be active against pathogens resistant to drugs that act by different mechanisms.
| Trade Name | Enoxacin - Bai Ke Heng Di Pharm |
| Availability | Discontinued |
| Generic | Enoxacin |
| Enoxacin Other Names | Enoxacin, Enoxacina, Énoxacine, Enoxacino, Enoxacinum |
| Related Drugs | amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, ceftriaxone, levofloxacin, Augmentin, amoxicillin / clavulanate |
| Type | |
| Formula | C15H17FN4O3 |
| Weight | Average: 320.3189 Monoisotopic: 320.128468635 |
| Protein binding | Enoxacin is approximately 40% bound to plasma proteins in healthy subjects and is approximately 14% bound to plasma proteins in patients with impaired renal function. |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | China |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of adults (≥18 years of age) with the following infections caused by susceptible strains of the designated microorganisms: (1) uncomplicated urethral or cervical gonorrhea due to Neisseria gonorrhoeae, (2) uncomplicated urinary tract infections (cystitis) due to Escherichia coli, Staphylococcus epidermidis, or Staphylococcus saprophyticus, and (3) complicated urinary tract infections due to Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus epidermidis, or Enterobacter cloacae.
How Enoxacin - Bai Ke Heng Di Pharm works
Enoxacin - Bai Ke Heng Di Pharm exerts its bactericidal action via the inhibition of the essential bacterial enzyme DNA gyrase (DNA Topoisomerase II).
Enoxacin - Bai Ke Heng Di Pharm multivitamins interaction
[Moderate] ADJUST DOSING INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics.
Absorption may also be reduced by sucralfate, which contains aluminum, as well as other polyvalent cations such as iron and zinc.
The mechanism is chelation of quinolones by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract.
The bioavailability of ciprofloxacin has been reported to decrease by as much as 90% when administered with antacids containing aluminum or magnesium hydroxide.
When coadministration cannot be avoided, quinolone antibiotics should be dosed either 2 to 4 hours before or 4 to 6 hours after polyvalent cation-containing products to minimize the potential for interaction.
When coadministered with Suprep Bowel Prep (magnesium Please consult individual product labeling for specific recommendations.
Enoxacin - Bai Ke Heng Di Pharm Drug Interaction
Major: warfarin, warfarinModerate: calcium / vitamin d, calcium / vitamin dMinor: torsemide, torsemide, furosemide, furosemideUnknown: spironolactone, spironolactone, amoxicillin / clavulanate, amoxicillin / clavulanate, glucose, glucose, albuterol / ipratropium, albuterol / ipratropium, haloperidol, haloperidol, heparin flush, heparin flush
Enoxacin - Bai Ke Heng Di Pharm Disease Interaction
Major: CNS disorders, myasthenia gravis, peripheral neuropathy, tendonitis
Elimination Route
Rapidly absorbed following oral administration, with an absolute oral bioavailability of approximately 90%.
Half Life
Plasma half-life is 3 to 6 hours.
Innovators Monograph
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