Epimag (Magnesium Citrate)
Epimag (Magnesium Citrate) Uses, Dosage, Side Effects, Food Interaction and all others data.
Epimag (Magnesium Citrate) is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Epimag (Magnesium Citrate) is considered by the FDA as an approved inactive ingredient for approved drug products under the specifications of oral administration of a maximum concentration of 237 mg. It is also considered as an active ingredient in over-the-counter products.
The onset of action can be as early as 30 minutes after administration with a mean onset time of approximately 2 hours and a maximum action of 4 hours. The effect of magnesium citrate is highly dependent on the individual's hydration status.
| Trade Name | Epimag (Magnesium Citrate) |
| Generic | Magnesium citrate |
| Magnesium citrate Other Names | Magnesium citrate, Magnesium dicitrate, Trimagnesium citrate, Trimagnesium dicitrate |
| Type | |
| Formula | C12H10Mg3O14 |
| Weight | Average: 451.113 Monoisotopic: 449.9621801 |
| Protein binding | Magnesium, once ionized, is highly bound to plasma proteins and it can represent even 90% of the magnesium found in blood plasma. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Oman |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Epimag (Magnesium Citrate) is a laxative used in bowel preparation for colonoscopy or as a magnesium supplement.
Epimag (Magnesium Citrate) has been used in bowel preparations prior to a colonoscopy as a cathartic agent.
It is also used in over-the-counter products to relieve occasional constipation.
Epimag (Magnesium Citrate) can be one of the forms used for the administration of dietary supplements.
Epimag (Magnesium Citrate) is also used to associated treatment for these conditions: Migraine
How Epimag (Magnesium Citrate) works
It mainly works through its property of high osmolality which will draw large amounts of fluid into the colonic lumen. There is also a possible stimulation of fluid excretion by cholecystokinin release and activation of muscle peristalsis.
Toxicity
The occurrence of overdose with magnesium citrate is very unlikely but some of the signs of the presence of overdose are diarrhea or severe stomach pain.
Food Interaction
- Take with or without food. Taking magnesium supplements with food may reduce the risk of diarrhea.
Elimination Route
Mean plasma concentration of magnesium after administration of oral doses of magnesium citrate are reported to be of around 0.7 mmol/L and the concentration in saliva rested in 0.28 mmol/L. In reports, it has also been proven that the absorption and bioavailability of magnesium are greater when administered in the form of magnesium citrate when compared with other forms such as magnesium ocude.
Half Life
The study of the half-life of magnesium citrate is very difficult due to the half-life of the available isotopes for magnesium.
Elimination Route
After oral administration of magnesium citrate, there is a 40% increase in urine excretion of magnesium. Epimag (Magnesium Citrate) is also widely eliminated via the feces because, when present in the bowel, it relaxes the bowel and pulls water into the intestine which increases bowel movement and a significant portion of this agent gets excreted by this via.
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