Epothilone B
Epothilone B Uses, Dosage, Side Effects, Food Interaction and all others data.
Epothilone B is a 16-membered macrolide that mimics the biological effects of taxol.
| Trade Name | Epothilone B |
| Generic | Patupilone |
| Patupilone Other Names | Epo B, Epothilone B, patupilona, Patupilone |
| Type | |
| Formula | C27H41NO6S |
| Weight | Average: 507.683 Monoisotopic: 507.265458739 |
| Groups | Experimental, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in ovarian cancer, lung cancer, brain cancer, breast cancer, and gastric cancer.
How Epothilone B works
The principal mechanism of the epothilone class is inhibition of microtubule function. Microtubules are essential to cell division, and epothilones therefore stop cells from properly dividing. Epothilone B possess the same biological effects as taxol both in vitro and in cultured cells. This is because they share the same binding site, as well as binding affinity to the microtubule. Like taxol, epothilone B binds to the αβ-tubulin heterodimer subunit. Once bound, the rate of αβ-tubulin dissociation decreases, thus stabilizing the microtubules. Furthermore, epothilone B has also been shown to induce tubulin polymerization into microtubules without the presence of GTP. This is caused by formation of microtubule bundles throughout the cytoplasm. Finally, epothilone B also causes cell cycle arrest at the G2-M transition phase, thus leading to cytotoxicity and eventually cell apoptosis.
Innovators Monograph
You find simplified version here Epothilone B
