Equizole

Equizole Uses, Dosage, Side Effects, Food Interaction and all others data.

2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for strongyloidiasis. It has CNS side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)

Equizole is a fungicide and parasiticide. Equizole is also a chelating agent, which means that it is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning. Equizole is vermicidal and/or vermifugal against Ascaris lumbricoides ("common roundworm"), Strongyloides stercoralis (threadworm), Necator americanus, Ancylostoma duodenale (hookworm), Trichuris trichiura (whipworm), Ancylostoma braziliense (dog and cat hookworm), Toxocara canis, Toxocara cati (ascarids), and Enterobius vermicularis (pinworm). Equizole also suppresses egg and/or larval production and may inhibit the subsequent development of those eggs or larvae which are passed in the feces.

Equizole
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Equizole
Availability	Discontinued
Generic	Thiabendazole
Thiabendazole Other Names	TBDZ, Thiabendazole, Tiabendazol, Tiabendazole, Tiabendazolum
Related Drugs	metronidazole, ivermectin, Flagyl, albendazole, mebendazole, nitazoxanide, piperazine, pyrantel, Albenza, Stromectol
Type
Formula	C₁₀H₇N₃S
Weight	Average: 201.248 Monoisotopic: 201.036067929
Groups	Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Equizole is a benzimidazole used in the treatment of strongyloides, cutaneous larva migrans, visceral larva migrans, and trichinosis infections.

For the treatment of strongyloidiasis (threadworm), cutaneous larva migrans (creeping eruption), visceral larva migrans, and trichinosis.

How Equizole works

The precise mode of action of thiabendazole on the parasite is unknown, but it most likely inhibits the helminth-specific enzyme fumarate reductase.

Toxicity

Overdosage may be associated with transient disturbances of vision and psychic alterations. The oral LD 50 is 3.6 g/kg, 3.1 g/kg and 3.8 g/kg in the mouse, rat, and rabbit respectively.

Equizole Drug Interaction

Unknown: amoxicillin / clavulanate, multivitamin with minerals, ciprofloxacin, sulfamethoxazole / trimethoprim, sulfamethoxazole / trimethoprim, glucose, lvp solution, multivitamin, metronidazole, multivitamin with minerals, acetaminophen, penicillin v potassium, tiotropium, ascorbic acid

Equizole Disease Interaction

Moderate: supportive therapy, liver disease, renal dysfunction

Elimination Route

Rapidly absorbed and peak plasma concentration is reached within 1 to 2 hours after the oral administration of a suspension. Some systemic absorption may occur from topical preparations applied to the skin.

Half Life

The half-life for thiabendazole in both normal and anephric patients is 1.2 hours (range 0.9 to 2 hours). The half-life for the 5-hydroxythiabendazole metabolite in both normal and anephric patients is 1.7 hours (range 1.4 to 2 hours).