Ergotop
Ergotop Uses, Dosage, Side Effects, Food Interaction and all others data.
An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease.
Ergotop is a potent vasodilator (improves brain blood flow). On the cerebral level it prompts a lowering of vascular resistance, an increase in arterial flow and stimulates the use of oxygen and glucose. Ergotop also improves blood circulation in the lungs and limbs and has been shown to inhibit blood platelet aggregation.
| Trade Name | Ergotop |
| Generic | Nicergoline |
| Nicergoline Other Names | Nicergolin, Nicergolina, Nicergoline, Nicergolinum |
| Type | |
| Formula | C24H26BrN3O3 |
| Weight | Average: 484.386 Monoisotopic: 483.11575436 |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | Austria, Czech Republic, Hungary |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Ergotop is an ergot derivative use for the treatment of symptoms associated with cerebrovascular abnormalities.
For the treatment of senile dementia, migraines of vascular origin, transient ischemia, platelet hyper-aggregability, and macular degeneration.
Ergotop is also used to associated treatment for these conditions: Stroke, Ischemic, Transient Ischemic Attack, Peripheral vasodilatation
How Ergotop works
Ergotop acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. Therefore the mechanism of Ergotop is to increase vascular circulation in the brain, thereby enhancing the transmission of nerve signals across the nerve fibres, which secrete acetylcholine as a neural transmitter.
Innovators Monograph
You find simplified version here Ergotop
