Esculina
Esculina Uses, Dosage, Side Effects, Food Interaction and all others data.
Esculina is found in barley. Vitamin C2 is generally considered a bioflavanoid, related to vitamin P esculin is a glucoside that naturally occurs in the horse chestnut (Aesculus hippocastanum), California Buckeye (Aesculus californica) and in daphnin (the dark green resin of Daphne mezereum). Esculina belongs to the family of Glycosyl Compounds. These are carbohydrate derivatives in which a sugar group is bonded through its anmoeric carbonA to another group via a C-, S-,N-,O-, or Se- glycosidic bond.
Topically applied Esculinae increases the “capillary density” (the number of capillaries open to flow per surface unit) and improves the morphological aspect of the smallest blood vessels.
Trade Name | Esculina |
Generic | Esculin |
Esculin Other Names | Aesculin, Aesculinum, Esculetin 6-O-glucoside, Esculina, Esculoside |
Type | |
Formula | C15H16O9 |
Weight | Average: 340.284 Monoisotopic: 340.079432095 |
Groups | Approved |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
As medication, esculin is sometimes used as a vasoprotective agent. Esculina is also used in a microbiology laboratory to aid in the identification of bacterial species (especially Enterococci and Listeria), as all strains of Group D Streptococci hydrolyze æsculin in 40% bile.
Esculina is also used to associated treatment for these conditions: Anal Fissures, Anal Fistulas, Hemorrhoids, Proctitis, Pruritus Ani, Cryptitis
How Esculina works
The main activities of Esculinae focus on capillary protection, as it improves capillary permeability and fragility. It is reported to inhibit catabolic enzymes such as hyaluronidase and collagenase, thus preserving the integrity of the perivascular connective tissue. Esculinae also showed good antioxidant properties, protecting triglycerides against auto-oxidation at high temperatures . The antioxidant property might as well explain some of the anti-inflammatory activity of the product, making it a suitable product for after sun treatments, for example.
Toxicity
Organism : Mouse Test type : LD50 Route: Intraperitoneal Reported dose: 1900mg/kg No reported effects known other than LD50
Food Interaction
No interactions found.Elimination Route
Rarely, absorbed into the blood stream if used as a combination with other ingredients in suppository form. But, Applying cream or ointment form to open wound or skin may lead this drug to absorb and circulate into blood stream.
Half Life
Absorption half life about 1 hour and elimination half life about 20 hours
Innovators Monograph
You find simplified version here Esculina