Esofour MUPS 20 mg MUPS Tablet
Esofour MUPS 20 mg MUPS Tablet Uses, Dosage, Side Effects, Food Interaction and all others data.
Esomeprazole MUPS 20 Tablet: Each MUPS tablet contains 133.333 mg (15%w/w) of Esomeprazole enteric coated pellets equivalent to 20 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP). Esomeprazole MUPS 40 Tablet: Each MUPS tablet contains 266.67 mg (15% w/w) of Esomeprazole enteric coated pellets equivalent to 40 mg Esomeprazole (as Esomeprazole Magnesium Trihydrate USP).| Trade Name | Esofour MUPS 20 mg MUPS Tablet |
| Generic | Esomeprazole (MUPS preparation) |
| Weight | 20 mg |
| Type | MUPS Tablet |
| Therapeutic Class | |
| Manufacturer | Albion Laboratories Limited |
| Available Country | Bangladesh |
| Last Updated: | September 24, 2024 at 5:38 am |
Uses
Esomeprazole MUPS tablet is indicated in: Gastro-esophageal Reflux Disease (GERD). Risk reduction in NSAID associated gastric ulcer. H. pylori eradication (Triple therapy). Zollinger-Ellison syndrome and idiopathic hypersecretion.Dosage
Esofour MUPS 20 mg MUPS Tablet dosage
Erosive esophagitis- Adult (≥18 years): 40 mg once daily for 4 weeks. Children & adolescents (12-18 years): 40 mg once daily for 4 weeks. Maintenance of healing of erosive esophagitis- Adult (≥18 years): 20 mg once daily. Children & adolescents (12-18 years): 20 mg once daily. Risk reduction in NSAID associated gastric ulcer- Adult (≥18 years): 20 mg once daily for 4-8 weeks. H. pylori eradication (Esomeprazole MUPS tablet with 1000 mg Amoxicillin and 500 mg Clarithromycin)- Adult (≥18 years): 20 mg twice daily for 7 days. Children & adolescents (12-18 years): 20 mg twice daily for 7 days. Zollinger-Ellison syndrome and idiopathic hypersecretion- Adult (≥18 years): 40-80 mg twice daily. Children 1-11 years: Erosive esophagitis: Weight <20 kg: 10 mg once daily for 8 weeks. Weight ≥20 kg: 10 mg or 20 mg once daily for 8 weeks Maintenance of healing of erosive esophagitis: 10 mg once daily Children below the age of 1 year: Esomeprazole MUPS tablet is not approved for use in children younger than 1 year. Esomeprazole MUPS tablets should be swallowed whole with liquid. The tablets should not be chewed or crushed. If required, the tablets can also be dispersed in half a glass of non-carbonated water (mineral water is not suitable). No other liquids should be used. Stir until the tablets disintegrate and drink the liquid with the pellets immediately or within 30 minutes. Rinse the glass with half a glass of water and drink. The pellets must not be chewed or crushed.Side Effects
The most frequently occurring adverse events reported with Esomeprazole include headache, diarrhoea, nausea, flatulence, abdominal pain, constipation and dry mouth. There are no difference in types of related adverse events seen during maintenance treatment upto 12 months compared to short term treatment.Precaution
Esomeprazole should be used carefully if the patient has severe liver dysfunction and severe renal impairment. Taking a proton pump inhibitor like Esomeprazole may slightly increase the risk of hip, wrist and spine fracture, particularly when it is taken over a period of more than one year.Interaction
Esomeprazole is extensively metabolized in the liver by CYP2C19 and CYP3A4. In vitro and in vivo studies have shown that Esomeprazole is not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4. No clinically relevant interactions with drugs metabolized by these CYP enzymes would be expected. Drug interaction studies have shown that Esomeprazole does not have any clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxicillin. Esomeprazole may potentially interfere with CYP2C19, the major Esomeprazole metabolizing enzyme. Co-administration of Esomeprazole 30 mg anddiazepam, a CYP2C19 substrate has resulted in a 45% decrease in clearance of diazepam. Increased plasma levels of diazepam have been observed 12 hours after dosing and onwards. Esomeprazole inhibits gastric acid secretion. Therefore, Esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (e.g., ketoconazole, iron salts and digoxin). Co-administration of oral contraceptives, diazepam, phenytoin, or quinidine do not seem to change the pharmacokinetic profile of Esomeprazole. Combination Therapy with Clarithromycin: Co-administration of esomeprazole, clarithromycin, and amoxicillin has resulted in increases in the plasma levels of esomeprazole and 14-hydroxyclarithromycin.Pregnancy & Breastfeeding use
The manufacturer advises caution. It is not known if Esomeprazole or its metabolites appear in human breast milk.Contraindication
Esomeprazole is contraindicated in patient with known hypersensitivity to any of the formulation.Storage Condition
Store in a cool & dry place below 25ºC, protect from light. Keep out of reach of children.Innovators Monograph
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